DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and fbxl15

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001011123.1	Gene:	fbxl15 / 496536	XenbaseID:	XB-GENE-973058	Length:	292	Species:	Xenopus tropicalis

Alignment Length:	284	Identity:	63/284 - (22%)
Similarity:	116/284 - (40%)	Gaps:	69/284 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 NSGINYFERLSDEILL-DIFKWLPKKTLLRMATV--------------CRRFNRCSRDETLWTRL 282
            ||.::..:...:::|: .|.:.||.:.:|.:..|              ||.|     |.|
Frog     7 NSSVHLLDLPWEDVLVPHILRNLPLRHILSLQRVSKPFQSLVHLYLANCRHF-----DST----- 61

  Fly   283 DLGLRTIRPGALEQIVRRGVLVIRLAQTSIQE--------PAFAPYTEVFRTRLQYLDLSMASIT 339
            .||.: :......:::|...::.:|...|..:        |.......:....|.    |...:|
Frog    62 QLGSQ-LPKSTFSELLRNNTVLQKLDLQSCCDWLTDKELLPVIGQNHHLIHINLN----SCGQLT 121

  Fly   340 RSSLLTLLSHCRQLKKISLENIELDD--------DICAEIAKNEALEAVNLTMASGLTSNSVRLM 396
            |.||:.:...|..|:.|.|.:.|..|        |.|      :.|||::||....|..:::..:
Frog   122 RQSLVAISLSCPHLQNICLGHCEWVDCLSLRSLVDHC------KCLEAIDLTACRQLKDDTISYL 180

  Fly   397 MESLTSLSSLNISWTDLSADAVTALVTHIS--------PNLIRLNIAGCRRVLFDSHVATLQKRC 453
            ::..|.|.||::        ||.|.::.|:        .:|..|::.||.||..|| :.||.:.|
Frog   181 VQKSTRLKSLSL--------AVNANISDIAVEETAKNCRDLEHLDLTGCLRVKNDS-IRTLAEYC 236

  Fly   454 PQLLELDLSDCNSLTPTVITAIMK 477
            .:|..|.:..|:::|.:.:..:.|
Frog   237 TKLKSLKVKHCHNVTESSLGNLRK 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	11/59 (19%)
		leucine-rich repeat	302..327	CDD:275381	3/32 (9%)
		AMN1	309..480	CDD:187754	46/193 (24%)
		leucine-rich repeat	328..352	CDD:275381	7/23 (30%)
		leucine-rich repeat	353..376	CDD:275381	7/30 (23%)
		leucine-rich repeat	377..402	CDD:275381	6/24 (25%)
		leucine-rich repeat	403..428	CDD:275381	7/32 (22%)
		leucine-rich repeat	429..455	CDD:275381	11/25 (44%)
		leucine-rich repeat	456..480	CDD:275381	5/22 (23%)
		leucine-rich repeat	481..500	CDD:275381
		leucine-rich repeat	506..529	CDD:275381
fbxl15	NP_001011123.1	leucine-rich repeat	47..81	CDD:275381	8/44 (18%)
		AMN1	65..251	CDD:187754	46/205 (22%)
		leucine-rich repeat	82..108	CDD:275381	3/25 (12%)
		leucine-rich repeat	109..134	CDD:275381	7/28 (25%)
		LRR 1	134..155		5/20 (25%)
		leucine-rich repeat	135..160	CDD:275381	7/30 (23%)
		LRR 2	160..181		6/20 (30%)
		leucine-rich repeat	161..186	CDD:275381	6/24 (25%)
		LRR 3	186..207		7/28 (25%)
		leucine-rich repeat	187..212	CDD:275381	7/32 (22%)
		LRR 4	212..233		9/21 (43%)
		leucine-rich repeat	213..238	CDD:275381	11/25 (44%)
		LRR 5	238..259		4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000