DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and CG14891

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_650560.1 Gene:CG14891 / 42013 FlyBaseID:FBgn0038445 Length:495 Species:Drosophila melanogaster


Alignment Length:376 Identity:91/376 - (24%)
Similarity:138/376 - (36%) Gaps:85/376 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 LSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGVLV-- 304
            ::|:|...:..:|.....|..|..|.||......::......|.::.:.. ...::::|.:|:  
  Fly   116 ITDDIWWKVLDYLSLNERLNFAASCERFQAIYELDSHRINHVLNMKDVCT-LTHRVIKRLMLLSG 179

  Fly   305 --IRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTL---LSHCRQL----------K 354
              |.........|.: ||...|   :|.|.:|..::|..|...:   |:|...|          .
  Fly   180 KHIHCVTGGPLHPNW-PYLTEF---VQLLGVSCPNLTELSFFKISVSLAHMTHLFDGANGLINIT 240

  Fly   355 KISLENIELDDDICAEIAKNEALEAVNLTMASGLTSNSVR----LMMESL----TSLSSLNIS-W 410
            .|||....|.|   |.|        ..|.|.|.|.|..:|    :..:||    .||..||:| .
  Fly   241 NISLRRCNLKD---AHI--------YCLQMLSKLKSLDIRENFSIKGDSLKSLPISLEILNVSGC 294

  Fly   411 TDLSADAV--TALVTHISPNLIRLNIAGCRRVLFDSHV-ATLQKRCPQLLELDLSD------CNS 466
            .|||...:  .|.::|    |..|...|..:...|:.: ..|...||.|..|:|:|      ...
  Fly   295 VDLSPKCLIQLAALSH----LRELRCPGIVKFAKDNELYGRLAHYCPMLEVLELTDFMNVIQLGG 355

  Fly   467 LTPTVITAIMKFKMLEYLSVSRCYLIPATKFIELKSMPSLTYLDIFGMLSDTAME---------- 521
            |:......|.....|:| .|:...|   |...|..|:..|..||.||.:|||:.:          
  Fly   356 LSRLHTLVIHSSAQLDY-HVNNVLL---TSIAESYSLRHLEILDSFGPMSDTSFDLSIFSQLKEL 416

  Fly   522 ---VLEKQ----LPKMGINK-----FIHSS----VSRPTVGTRRTSIWGLR 556
               :|..|    |..||:.|     |:..|    :|...|.....|:.|||
  Fly   417 RTLILHNQNFTTLHLMGLQKLSTLEFLDLSGSPNLSNEVVAKLTKSLSGLR 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 8/41 (20%)
leucine-rich repeat 302..327 CDD:275381 6/28 (21%)
AMN1 309..480 CDD:187754 50/201 (25%)
leucine-rich repeat 328..352 CDD:275381 7/26 (27%)
leucine-rich repeat 353..376 CDD:275381 8/32 (25%)
leucine-rich repeat 377..402 CDD:275381 8/32 (25%)
leucine-rich repeat 403..428 CDD:275381 9/27 (33%)
leucine-rich repeat 429..455 CDD:275381 6/26 (23%)
leucine-rich repeat 456..480 CDD:275381 6/29 (21%)
leucine-rich repeat 481..500 CDD:275381 5/18 (28%)
leucine-rich repeat 506..529 CDD:275381 11/39 (28%)
CG14891NP_650560.1 RRM_6 25..91 CDD:290958
AMN1 <199..352 CDD:187754 45/170 (26%)
leucine-rich repeat 211..237 CDD:275381 5/25 (20%)
leucine-rich repeat 239..262 CDD:275381 9/33 (27%)
leucine-rich repeat 263..285 CDD:275381 5/21 (24%)
leucine-rich repeat 286..338 CDD:275381 15/55 (27%)
leucine-rich repeat 339..387 CDD:275381 12/51 (24%)
leucine-rich repeat 388..415 CDD:275381 8/26 (31%)
leucine-rich repeat 416..439 CDD:275381 6/22 (27%)
leucine-rich repeat 440..465 CDD:275381 5/24 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453477
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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