DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and fbxl15

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_998107.1	Gene:	fbxl15 / 405878	ZFINID:	ZDB-GENE-040426-2440	Length:	296	Species:	Danio rerio

Alignment Length:	313	Identity:	74/313 - (23%)
Similarity:	125/313 - (39%)	Gaps:	79/313 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 DEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGVLVIRLA 308
            |.::..:|..||.:.|:.:..|.:.|.     ..:...|| ..||..|                |
Zfish    23 DVLVSHVFCHLPLRLLVSLQRVSKSFR-----SLIQVYLD-NCRTFDP----------------A 65

  Fly   309 QTSIQEPAFAPYTEVFRTR--LQYLDLSMAS--ITRSSLLTLLSHCRQLKKISLENIELDDDICA 369
            ||....|..| :..:.|..  ||:|.::..|  ||.:.||.::...:||:.:.|..       ||
Zfish    66 QTGPHIPREA-FCSILRHNQVLQHLSVTNCSDWITDTDLLPVIGQNQQLQHVDLRG-------CA 122

  Fly   370 EIAKNEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWTDLSADAVTALVTHISPNLIRLNI 434
            :::: .||.||:|:             ...|..||..:..|.|  :.|:.:|..| .|.|..|::
Zfish   123 QLSR-RALVAVSLS-------------CPRLQHLSLAHCEWVD--SLALRSLADH-CPMLRSLDL 170

  Fly   435 AGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMKFKMLEYLSVSRCYLIPATKFIE 499
            ..||: |.|..|..|..:||:|..|.::...::|.|.:..:.|          :|
Zfish   171 TACRQ-LKDPAVCYLAGKCPELRALSVAVNANITDTAVEEVAK----------KC---------- 214

  Fly   500 LKSMPSLTYLDIFGML--SDTAMEVLEKQLPKMGINKFIH-SSVSRPTVGTRR 549
                ..:..||:.|.|  .:.|:..|.:..||:...|..| .:|:..::|..|
Zfish   215 ----REMERLDLTGCLRVRNEAIRTLAEYCPKLQSLKVNHCHNVTESSLGVLR 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	8/39 (21%)
		leucine-rich repeat	302..327	CDD:275381	6/24 (25%)
		AMN1	309..480	CDD:187754	47/174 (27%)
		leucine-rich repeat	328..352	CDD:275381	8/25 (32%)
		leucine-rich repeat	353..376	CDD:275381	4/22 (18%)
		leucine-rich repeat	377..402	CDD:275381	5/24 (21%)
		leucine-rich repeat	403..428	CDD:275381	7/24 (29%)
		leucine-rich repeat	429..455	CDD:275381	9/25 (36%)
		leucine-rich repeat	456..480	CDD:275381	5/23 (22%)
		leucine-rich repeat	481..500	CDD:275381	1/18 (6%)
		leucine-rich repeat	506..529	CDD:275381	6/24 (25%)
fbxl15	NP_998107.1	F-box	16..>52	CDD:279040	7/33 (21%)
		leucine-rich repeat	51..85	CDD:275381	11/51 (22%)
		leucine-rich repeat	86..112	CDD:275381	8/25 (32%)
		AMN1	<111..272	CDD:187754	48/202 (24%)
		leucine-rich repeat	113..138	CDD:275381	9/45 (20%)
		LRR 1	138..159		6/22 (27%)
		leucine-rich repeat	139..164	CDD:275381	8/27 (30%)
		LRR 2	164..185		7/21 (33%)
		leucine-rich repeat	165..190	CDD:275381	9/25 (36%)
		LRR 3	190..211		4/20 (20%)
		leucine-rich repeat	191..216	CDD:275381	6/48 (13%)
		LRR 4	216..237		5/20 (25%)
		leucine-rich repeat	217..242	CDD:275381	6/24 (25%)
		LRR 5	242..263		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840