DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and CG32085

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_729732.1 Gene:CG32085 / 39311 FlyBaseID:FBgn0052085 Length:666 Species:Drosophila melanogaster


Alignment Length:587 Identity:131/587 - (22%)
Similarity:218/587 - (37%) Gaps:138/587 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 PSSPSALTFEALEEMGIGMLDSEESSSSALSAIALAVSATSDDNSNETTPCASVSRMAHQLQHTQ 111
            |::||..| ..:|.:...:.....|:|::.|.     |:.|:.:|...|...|.:..|:..|...
  Fly    55 PAAPSGKT-SVMERVTNALCGGGNSNSNSGSN-----SSNSNTSSASATAATSPASNANPPQTPD 113

  Fly   112 RLSLGST---GDITL--DSPAVEDS----LSMSRQSAEKLQILAQAKRSSLGSEGSG--NSN--- 162
            :.|.||:   |.||:  ....|::|    |...:|..:.:| |.|:::..|..:.|.  |||   
  Fly   114 KPSRGSSPSPGGITMPGGQSQVQNSTHHLLQQQQQQQQHMQ-LQQSQQQHLQLQASTLINSNHHV 177

  Fly   163 --SPSKRLRNPLA----------AVTCNNQIDGTASLNFQPSTSRLAQVRQAKKPSTTNITTRIV 215
              .|:.....||.          |...|..|.|.......|:.|.:..|...|..::        
  Fly   178 MVGPAPPTGMPLGAPPTPTVKSIAKQMNITIPGGGVNPGSPTFSTMGMVAAQKAAAS-------- 234

  Fly   216 AADSFFVFRTPAMSAHI-----NSGINYFE-------------------RLSDEILLDIFKWLPK 256
            |..:....|....:.|:     :.|||...                   .|.|..|...|::...
  Fly   235 AGGTPLQLRKQLPNPHLHHPYGSMGINAASPLIMQHQLHPPPIHSIEQLMLDDRFLSRFFQYFSP 299

  Fly   257 KTLLRMATVCRRF-NRCSRDETLWTRL--DLGLRTIR--PGA-----LEQIVRRGVLVIRLAQTS 311
            .....:|.||.:: :...|....|:.|  .|..|.:|  ||.     ...::|||...:.|...|
  Fly   300 YERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCRELRQMPGCDRGKLYNSLIRRGFHALGLVGAS 364

  Fly   312 IQEPAFAPYTEVFRTR-LQYLDLSMASITRSSLLTLLSHCRQLKKISLENIELDDDICAEIAKNE 375
            .::.....::....:: :..|.|..:||:...|.|||.|.:.|.::.|..       |     ||
  Fly   365 DEDALDVVHSFPLASKHVHSLSLRCSSISDRGLETLLDHLQSLFELELAG-------C-----NE 417

  Fly   376 ALEA----------VNLTMAS--GLTSNSVRLMMESLTSL-----------------------SS 405
            ..||          |:|::|.  .:...:|..:.:.|.||                       .|
  Fly   418 VTEAGLWACLTPRIVSLSLADCINIADEAVGAVAQLLPSLYEFSLQAYHVTDAALGYFSPKQSHS 482

  Fly   406 LNI----SWTDLSADAVTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNS 466
            |:|    |..:|:...:..:| |..|:|..|:::||.: |.|..|..:.:...:|..||||.|..
  Fly   483 LSILRLQSCWELTNHGIVNIV-HSLPHLTVLSLSGCSK-LTDDGVELIAENLQKLRALDLSWCPR 545

  Fly   467 LTPTVITAI-MKFKMLEYLSVSRCYLIPATKFIELKSMPSLTYLDI--------FGMLSDTAMEV 522
            :|...:..| .....||.|::.||..|.......:.:|.|||.|.:        ||:....:|..
  Fly   546 ITDASLEYIACDLNQLEELTLDRCVHITDIGVGYISTMLSLTALFLRWCSQVRDFGLQHLCSMRN 610

  Fly   523 LE 524
            |:
  Fly   611 LQ 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 10/66 (15%)
leucine-rich repeat 302..327 CDD:275381 2/24 (8%)
AMN1 309..480 CDD:187754 47/211 (22%)
leucine-rich repeat 328..352 CDD:275381 9/23 (39%)
leucine-rich repeat 353..376 CDD:275381 4/22 (18%)
leucine-rich repeat 377..402 CDD:275381 7/36 (19%)
leucine-rich repeat 403..428 CDD:275381 8/51 (16%)
leucine-rich repeat 429..455 CDD:275381 7/25 (28%)
leucine-rich repeat 456..480 CDD:275381 8/24 (33%)
leucine-rich repeat 481..500 CDD:275381 6/18 (33%)
leucine-rich repeat 506..529 CDD:275381 7/27 (26%)
CG32085NP_729732.1 leucine-rich repeat 382..406 CDD:275381 9/23 (39%)
AMN1 383..600 CDD:187754 57/230 (25%)
leucine-rich repeat 431..456 CDD:275381 5/24 (21%)
leucine-rich repeat 457..482 CDD:275381 1/24 (4%)
leucine-rich repeat 483..508 CDD:275381 6/25 (24%)
leucine-rich repeat 509..534 CDD:275381 7/25 (28%)
leucine-rich repeat 535..560 CDD:275381 8/24 (33%)
leucine-rich repeat 561..585 CDD:275381 7/23 (30%)
leucine-rich repeat 586..610 CDD:275381 6/23 (26%)
leucine-rich repeat 636..661 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45457968
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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