Protein Alignment Skp2 and fbxl2

DIOPT Version :10

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_956400.1
• Gene: fbxl2 / 378737
• ZFINID: ZDB-GENE-030925-12
• Length: 432
• Species: Danio rerio
• Alignment Length: 347
• Identity: 79/347 - (22%)
• Similarity: 155/347 - (44%)
• Gaps: 71/347 - (20%)

  Fly   224 RTPAMSAHINSGINYFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDL-GLR 287
            |....|.:..:.||  ::|..|:||.||.:|...||.|.|.|.:.:|..:.|.:.|.::|| ..:
Zfish     8 RFEVFSNNDEAPIN--KKLPKELLLRIFSYLDVVTLCRCAQVSKAWNVLALDGSNWQKIDLFNFQ 70

  Fly   288 T-IRPGALEQIVRR--GVLVIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSH 349
            | |....:|.|.:|  |.    |.|.|::                    ...|:..:|:.|...:
Zfish    71 TDIEGRVVENISKRCGGF----LRQLSLR--------------------GCLSVGDASMKTFAQN 111

  Fly   350 CRQLKKISLEN-IELDDDICAEIAK-NEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWTD 412
            ||.::.::|.. .::.|..|..::| ...|..::||....:|:::::.:.|....|.:||:||.|
Zfish   112 CRNIEHLNLNGCTKITDSTCISLSKFCFKLRHLDLTSCVSITNHALKALSEGCRMLENLNLSWCD 176

  Fly   413 -LSADAVTAL----------------------VTHIS---PNLIRLNIAGCRRVLFDSHVATLQK 451
             :::|.:.||                      :.|:.   |.|:.:|:..|.::..|..| :|.:
Zfish   177 QITSDGIEALSRGCTALRALFLRGCTQLDDTALKHLQKHCPELMTINMQSCTQITDDGFV-SLCR 240

  Fly   452 RCPQLLELDLSDCNSLTPTVITAI-MKFKMLEYLSVSRC-------YLIPATKFIELKSMPSLTY 508
            .|.:|..:.:|.|:::|...:||: :..:.|:.|..:||       :.:.|....|::.|.
Zfish   241 GCHKLQMVCISGCSNITDASLTALGLNCQRLKILEAARCSHVTDAGFTVLARNCHEMEKMD---- 301

  Fly   509 LDIFGMLSDTAMEVLEKQLPKM 530
            |:...:::|..:..|....|::
Zfish   302 LEECILVTDNTLVQLSIHCPRL 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box_DmSKP2-like	239..281	CDD:438920	15/41 (37%)
		leucine-rich repeat	302..327	CDD:275381	3/24 (13%)
		AMN1	309..480	CDD:187754	40/199 (20%)
		leucine-rich repeat	328..352	CDD:275381	4/23 (17%)
		leucine-rich repeat	353..376	CDD:275381	4/24 (17%)
		leucine-rich repeat	377..402	CDD:275381	5/24 (21%)
		leucine-rich repeat	403..428	CDD:275381	10/50 (20%)
		leucine-rich repeat	429..455	CDD:275381	7/25 (28%)
		leucine-rich repeat	456..480	CDD:275381	6/24 (25%)
		leucine-rich repeat	481..500	CDD:275381	5/25 (20%)
		leucine-rich repeat	506..529	CDD:275381	3/22 (14%)
fbxl2	NP_956400.1	F-box_FBXL2-like	18..62	CDD:438887	16/45 (36%)
		leucine-rich repeat	61..88	CDD:275381	8/26 (31%)
		AMN1	63..284	CDD:187754	53/245 (22%)
		leucine-rich repeat	89..108	CDD:275381	5/38 (13%)
		leucine-rich repeat	115..140	CDD:275381	4/24 (17%)
		leucine-rich repeat	141..166	CDD:275381	5/24 (21%)
		leucine-rich repeat	167..192	CDD:275381	9/24 (38%)
		leucine-rich repeat	193..218	CDD:275381	1/24 (4%)
		AMN1	212..390	CDD:187754	25/117 (21%)
		leucine-rich repeat	219..244	CDD:275381	7/25 (28%)
		leucine-rich repeat	245..270	CDD:275381	6/24 (25%)
		leucine-rich repeat	271..296	CDD:275381	5/24 (21%)
		leucine-rich repeat	297..322	CDD:275381	4/28 (14%)
		leucine-rich repeat	323..351	CDD:275381	0/1 (0%)
		leucine-rich repeat	352..376	CDD:275381
		leucine-rich repeat	377..402	CDD:275381