DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and Fbxl6

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_001005563.1 Gene:Fbxl6 / 362941 RGDID:1359687 Length:535 Species:Rattus norvegicus


Alignment Length:358 Identity:74/358 - (20%)
Similarity:122/358 - (34%) Gaps:95/358 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   226 PAMSAHINSGINYFERLSDEILLDIFKWL-----PKKTLLRMATVCRRFNRCSRDETLWTRLDLG 285
            |::...::||  :.:|:..|:|:.||..|     |...|.|.|.|||.::..:...:||..:.|.
  Rat    93 PSLDQGLDSG--WGDRIPLEVLVHIFGLLVAAHGPMPFLGRAARVCRHWHEATSHPSLWHTVTLS 155

  Fly   286 ---------------------LRTIRPGALEQIVRRGVLVIRLAQTSIQEPAFAPYTEVFRTRLQ 329
                                 |..:.|....|:.|     :.|.....|..:.......|..||.
  Rat   156 PALVGRAAKGNLKGEKKLLACLEWLIPNRFSQLQR-----LTLIHWKSQVHSVLELVSKFCPRLT 215

  Fly   330 YLDLS-MASITRSSLLTLLSHCRQLKKISLENIELDDD--------------------------I 367
            :|.|| ...:|..:|:.|...|.||..:.|.:..::..                          |
  Rat   216 FLKLSDCHGVTAETLVMLAKACCQLHSLDLHHSMVESTAVVSFLEEAGSRMRRLWLTYSSQTTAI 280

  Fly   368 CAEIAKNEALEAVNLTMASGLTSNSVRLMM---------ESLTSLSSLNISWTDLSADAVTALVT 423
            ...:..|...:...|.:::|::.|:..|.:         ..|..|..||:.|.............
  Rat   281 LGALLGNCCSQLQVLEVSAGMSCNNTPLQLPVEALQRGCPQLQVLRLLNLIWLPKPCGRGAPQGP 345

  Fly   424 HISPNLIRLNIAGCRRVLFDSHVATLQKRC-PQLLELDLSDCNSLTPTVITAIMKFKMLEYLSVS 487
            .. |:|..|.:||.......:.|......| |:|..|||..|..:|||.:               
  Rat   346 GF-PSLEELCLAGSTCSFVSNEVLGRLLHCSPKLRLLDLRGCARITPTGL--------------- 394

  Fly   488 RCYLIPATKFIELKSMPSLTYLDIFGMLSDTAM 520
             |:| |..:..:|       ||.::||....|:
  Rat   395 -CHL-PCQELEQL-------YLGLYGMSDGLAL 418

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 15/49 (31%)
leucine-rich repeat 302..327 CDD:275381 3/24 (13%)
AMN1 309..480 CDD:187754 41/207 (20%)
leucine-rich repeat 328..352 CDD:275381 8/24 (33%)
leucine-rich repeat 353..376 CDD:275381 4/48 (8%)
leucine-rich repeat 377..402 CDD:275381 5/33 (15%)
leucine-rich repeat 403..428 CDD:275381 4/24 (17%)
leucine-rich repeat 429..455 CDD:275381 6/26 (23%)
leucine-rich repeat 456..480 CDD:275381 8/23 (35%)
leucine-rich repeat 481..500 CDD:275381 3/18 (17%)
leucine-rich repeat 506..529 CDD:275381 5/15 (33%)
Fbxl6NP_001005563.1 F-box-like 105..155 CDD:289689 15/49 (31%)
AMN1 171..390 CDD:187754 43/224 (19%)
leucine-rich repeat 188..213 CDD:275381 4/29 (14%)
leucine-rich repeat 214..239 CDD:275381 8/24 (33%)
leucine-rich repeat 240..291 CDD:275381 4/50 (8%)
leucine-rich repeat 292..321 CDD:275381 4/28 (14%)
leucine-rich repeat 322..349 CDD:275381 5/27 (19%)
AMN1 <349..500 CDD:187754 24/94 (26%)
leucine-rich repeat 350..377 CDD:275381 6/26 (23%)
leucine-rich repeat 378..401 CDD:275381 11/39 (28%)
leucine-rich repeat 434..466 CDD:275381
leucine-rich repeat 467..491 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166346581
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR16134
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.030

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