DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and Fbxl7

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_001102015.1 Gene:Fbxl7 / 361907 RGDID:1305813 Length:491 Species:Rattus norvegicus


Alignment Length:438 Identity:105/438 - (23%)
Similarity:170/438 - (38%) Gaps:104/438 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 GSEGSGNS-----------NSPSKRLRN----------------PLAAVTC--------NNQIDG 183
            ||||.|:|           ::|:|..:|                |..|:.|        |.:...
  Rat    10 GSEGKGSSSVSSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPALPGFQNGRGSS 74

  Fly   184 TASLNFQPSTSRLAQVRQAKKPSTTNITTRIVAADSFFVFRTPAMSAHINSGINYFERLSDEILL 248
            |:|.:....|     |.....|..|.:|..::...|    |.....|.|       :||.|..::
  Rat    75 TSSSSITGET-----VAMVHSPPPTRLTHPLIRLAS----RPQKEQASI-------DRLPDHSMV 123

  Fly   249 DIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGVLVIRLAQTSIQ 313
            .||.:||...|.|.|.||||:...:.|..||..:.|...||.   :::.::  ||..||.|.:  
  Rat   124 QIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETIN---VDRALK--VLTRRLCQDT-- 181

  Fly   314 EPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLENIELDDDICAEIAKNEA-- 376
             |......|.      .:......:|...|.|:...|.:|:::.:..       |..|: |||  
  Rat   182 -PNVCLMLET------VIVSGCRRLTDRGLYTIAQCCPELRRLEVSG-------CYNIS-NEAVF 231

  Fly   377 --------LEAVNLTMASGLTSNSVRLMMESLTSLSSLN--------ISWTD---LSADAVTALV 422
                    ||.::::..|.:|  .:.|..|:...||.|:        :..||   |..:.:..:.
  Rat   232 DVVSLCPNLEHLDVSGCSKVT--CISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIA 294

  Fly   423 THISPNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMKFK-MLEYLSV 486
            .|.: .|..|.:..|.| |.|..:..|...|..:.||.:|||..::...:..|.|.: .|.|||:
  Rat   295 AHCT-QLTHLYLRRCVR-LTDEGLRYLVIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSI 357

  Fly   487 SRCYLIP--ATKFIELKSMPSLTYLDIFGM--LSDTAMEVLEKQLPKM 530
            :.|..|.  ..::: .|....|.||:..|.  ::|..:|.|.|...|:
  Rat   358 AHCGRITDVGIRYV-AKYCSKLRYLNARGCEGITDHGVEYLAKNCTKL 404

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 17/44 (39%)
leucine-rich repeat 302..327 CDD:275381 7/24 (29%)
AMN1 309..480 CDD:187754 41/192 (21%)
leucine-rich repeat 328..352 CDD:275381 4/23 (17%)
leucine-rich repeat 353..376 CDD:275381 4/22 (18%)
leucine-rich repeat 377..402 CDD:275381 6/24 (25%)
leucine-rich repeat 403..428 CDD:275381 7/35 (20%)
leucine-rich repeat 429..455 CDD:275381 8/25 (32%)
leucine-rich repeat 456..480 CDD:275381 7/24 (29%)
leucine-rich repeat 481..500 CDD:275381 6/20 (30%)
leucine-rich repeat 506..529 CDD:275381 8/24 (33%)
Fbxl7NP_001102015.1 F-box-like 114..160 CDD:289689 18/52 (35%)
leucine-rich repeat 129..151 CDD:275381 9/21 (43%)
leucine-rich repeat 154..187 CDD:275381 10/40 (25%)
AMN1 <185..366 CDD:187754 45/198 (23%)
leucine-rich repeat 188..213 CDD:275381 5/30 (17%)
leucine-rich repeat 214..234 CDD:275381 6/27 (22%)
leucine-rich repeat 240..273 CDD:275381 9/34 (26%)
leucine-rich repeat 274..299 CDD:275381 4/25 (16%)
AMN1 297..464 CDD:187754 31/111 (28%)
leucine-rich repeat 300..325 CDD:275381 8/25 (32%)
leucine-rich repeat 326..351 CDD:275381 7/24 (29%)
leucine-rich repeat 352..377 CDD:275381 7/25 (28%)
leucine-rich repeat 378..403 CDD:275381 8/24 (33%)
leucine-rich repeat 404..429 CDD:275381 0/1 (0%)
leucine-rich repeat 430..453 CDD:275381
leucine-rich repeat 456..480 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166346676
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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