DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and CG15056

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_573291.1	Gene:	CG15056 / 32824	FlyBaseID:	FBgn0030918	Length:	399	Species:	Drosophila melanogaster

Alignment Length:	337	Identity:	70/337 - (20%)
Similarity:	132/337 - (39%)	Gaps:	95/337 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 DEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGV----LV 304
            |...||:.|.|..|:.:..|..|..|      |.::.| ...||..|...||:::...:    |.
  Fly    13 DFFWLDVLKQLDLKSRISFAASCDMF------ENIYVR-SSPLRLSRVVNLEEMIEFSLLETKLF 70

  Fly   305 IRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLENIELDDDICA 369
            :.|:.:.|:.....|:|.:|.....::.|....:|:            :.:|:||..:|     .
  Fly    71 VELSGSDIEIIRGGPHTPMFSHFEDFIRLMSIRLTK------------VNEIALEGFQL-----T 118

  Fly   370 EIAKNEALEAVNLTMASGLTSNSVR---------LMMESLTSLSSLNISWTD-LSADAVTALVTH 424
            :.....|.|    |..|.||..|:|         :..|.||.|.:|::.:.| |:...:.:|.|
  Fly   119 QYKWFNAPE----TSFSNLTYVSLRRCQLNDENLVGWEFLTHLETLDLRYNDRLTGSCLMSLPT- 178

  Fly   425 ISPNLIRLNIAGCR-----RVLFDSHVATLQK--------------------RCPQLLELDLSDC 464
               :|:.|.|.|||     :::|.:.:..|::                    .||.|:.:::|.|
  Fly   179 ---SLLSLYITGCRNLCPNQLIFLNRIPRLRELRASDLMPGGHWHIYRDLVLACPLLVMVEISIC 240

  Fly   465 N------------SLTPTVI----TAIMKFKMLEYLSVSRCYLIPATKFIELKSMPSLTYLDIFG 513
            :            .|...||    |..::.|:.:::.:| ...:|..:.:.....||       |
  Fly   241 SLNRDEYRLGELRYLQSLVIKAHSTDTIRCKVSDWMLIS-LLDVPFLRNLMFSDAPS-------G 297

  Fly   514 MLSDTAMEVLEK 525
            .:|..|:.::.:
  Fly   298 FVSANALSIISR 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	11/39 (28%)
		leucine-rich repeat	302..327	CDD:275381	6/28 (21%)
		AMN1	309..480	CDD:187754	44/221 (20%)
		leucine-rich repeat	328..352	CDD:275381	2/23 (9%)
		leucine-rich repeat	353..376	CDD:275381	4/22 (18%)
		leucine-rich repeat	377..402	CDD:275381	9/33 (27%)
		leucine-rich repeat	403..428	CDD:275381	6/25 (24%)
		leucine-rich repeat	429..455	CDD:275381	9/50 (18%)
		leucine-rich repeat	456..480	CDD:275381	7/39 (18%)
		leucine-rich repeat	481..500	CDD:275381	2/18 (11%)
		leucine-rich repeat	506..529	CDD:275381	3/20 (15%)
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	6/22 (27%)
		leucine-rich repeat	157..179	CDD:275381	6/25 (24%)
		leucine-rich repeat	180..204	CDD:275381	7/23 (30%)
		leucine-rich repeat	205..231	CDD:275381	2/25 (8%)
		leucine-rich repeat	232..285	CDD:275381	9/53 (17%)
		leucine-rich repeat	286..326	CDD:275381	5/31 (16%)
		AMN1	306..>376	CDD:187754	0/4 (0%)
		leucine-rich repeat	337..362	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457997
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930