DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and fbxl6

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_001296447.1 Gene:fbxl6 / 323163 ZFINID:ZDB-GENE-060810-162 Length:564 Species:Danio rerio


Alignment Length:508 Identity:101/508 - (19%)
Similarity:176/508 - (34%) Gaps:155/508 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 SAIALAVSA---TSDDNSNETTPCASVSRMAHQLQHTQRLSLGSTGDITLDSPAVEDSLSMSRQS 138
            |.:|.|.||   .:..:..||:|.....|.|                 .|...|  |||...:..
Zfish     3 STVAQASSAEMSAAQSSRAETSPTKPAKRKA-----------------PLKRKA--DSLKDDKSK 48

  Fly   139 AEKLQILAQAKRSS------------LGSEGSGNSNSPSKRLRNPLAAVTCNNQIDGTASLNFQP 191
            .:|.:.:.:..|.:            :.:..||:|....||............:..|:.|     
Zfish    49 KKKRKPVKRTVRPNYTVQEGEDMLLIISNISSGDSVWKPKRKVGKKKKTNKKAKTKGSTS----- 108

  Fly   192 STSRLAQVRQAKKPSTTNI-TTRIVAADSFFVFRTPAMSAHINSGINYFERLSDEILLDIFKW-- 253
                    ::.|.|..|.: ..|....|...|..    ||..:...::.:.|..|||:.||::  
Zfish   109 --------KKEKAPVKTEVLKVREETDDKHDVMD----SAKTDRFDHWGQSLPLEILVKIFQFAV 161

  Fly   254 -----LPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGVLVIRLAQTSIQ 313
                 :|  .|.|:..|||.:|..:....||..:.:|...|.||..:                  
Zfish   162 FQDGAVP--LLCRVGRVCRLWNGAASSPILWRSVSIGYCWIEPGKSQ------------------ 206

  Fly   314 EPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISL----ENIELDDDICAEIAKN 374
                .|.||      |.:..::..:..:.|.       ||::.||    :|:   |.:..:::::
Zfish   207 ----LPGTE------QKIKNTVDWLAENRLF-------QLREFSLCHWKKNV---DYVIQKVSQS 251

  Fly   375 -EALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWTDLSADAVTALV------------THI- 425
             .:|.::.|:..:|:|..:.:.:.....||..:|:..::::.|.:.:.:            ||. 
Zfish   252 CLSLHSLKLSYCTGMTEKAFQNLGADCQSLEDINVQHSEINVDGLVSFLEAYGNQIKKIYFTHST 316

  Fly   426 -SPNLIRLNIAGCRRVLFDSHVAT---------------LQKRCPQLLELDLSDCNSLTPTVITA 474
             |..|:.....||...|....:.|               ||..||:|....|.:..:: |.:|..
Zfish   317 KSDKLLSALSKGCCPELRLLEINTKLDGGYSQLPICIQGLQIGCPKLQTFRLMNVTAV-PKMIRN 380

  Fly   475 IMK----FKMLEYLSVSRCYLIPATKFIE----------LKSMPSLTYLDIFG 513
            |..    |.|||.|.:       ||.|..          |...|:|..||:.|
Zfish   381 IPSSTCGFPMLEELCI-------ATSFHSFMTDNDLNNVLHGSPNLRVLDLRG 426

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 15/51 (29%)
leucine-rich repeat 302..327 CDD:275381 3/24 (13%)
AMN1 309..480 CDD:187754 37/208 (18%)
leucine-rich repeat 328..352 CDD:275381 2/23 (9%)
leucine-rich repeat 353..376 CDD:275381 5/27 (19%)
leucine-rich repeat 377..402 CDD:275381 4/24 (17%)
leucine-rich repeat 403..428 CDD:275381 6/38 (16%)
leucine-rich repeat 429..455 CDD:275381 8/40 (20%)
leucine-rich repeat 456..480 CDD:275381 6/27 (22%)
leucine-rich repeat 481..500 CDD:275381 6/28 (21%)
leucine-rich repeat 506..529 CDD:275381 4/8 (50%)
fbxl6NP_001296447.1 F-box-like 147..195 CDD:289689 15/49 (31%)
AMN1 213..396 CDD:187754 37/193 (19%)
leucine-rich repeat 229..254 CDD:275381 5/27 (19%)
leucine-rich repeat 255..280 CDD:275381 4/24 (17%)
leucine-rich repeat 281..306 CDD:275381 3/24 (13%)
leucine-rich repeat 307..334 CDD:275381 6/26 (23%)
leucine-rich repeat 335..362 CDD:275381 4/26 (15%)
AMN1 <391..>542 CDD:187754 12/43 (28%)
leucine-rich repeat 391..418 CDD:275381 7/33 (21%)
leucine-rich repeat 419..438 CDD:275381 4/8 (50%)
leucine-rich repeat 445..473 CDD:275381
leucine-rich repeat 475..505 CDD:275381
leucine-rich repeat 506..530 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170588017
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.840

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