DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and fbxl5

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_001288257.1 Gene:fbxl5 / 322181 ZFINID:ZDB-GENE-030131-900 Length:679 Species:Danio rerio


Alignment Length:317 Identity:75/317 - (23%)
Similarity:118/317 - (37%) Gaps:112/317 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   242 LSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIR-------PGAL----- 294
            |..|:||.||::|..:.|.|.|.||..:.:.:|..:||..| ..:|..|       ||.|     
Zfish   211 LPQELLLRIFRFLGPQDLCRCAQVCSVWTQVTRTGSLWRHL-YPVRWARGEYYSGPPGDLDLEPD 274

  Fly   295 EQIVRRGVLVIRLAQTSIQEP--AFAPYTEVFRTRLQYLDLSM-----ASITRSSLLTLLSHCRQ 352
            :..::           |:|:.  |:..:.|         |..:     ||..|||:..|     |
Zfish   275 DDWIK-----------SLQDDGRAYQEWDE---------DADVDESEEASAERSSISAL-----Q 314

  Fly   353 LKKISLENIELDDDICAEIAK-----NEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWTD 412
            .:|:.|..|         |.|     ..::.:::|..:|.|:|..||.|:....:|:.|:::.||
Zfish   315 REKLLLNGI---------IQKLLPAVGSSVRSLSLAYSSTLSSKMVRQMLSLCPNLTHLDLTQTD 370

  Fly   413 LSADAVTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMK 477
            :|..|                        |||..|.  ..|..|..||||.|:.:|.        
Zfish   371 VSDSA------------------------FDSWCAL--GACGTLQHLDLSGCDKITD-------- 401

  Fly   478 FKMLEYLSV---SRCYLIPATKFIELKSMPSLTYLDIFGMLSDTAMEVLEKQLPKMG 531
             :.|:.|||   ......||.|.::....|               :.:.|.:|..||
Zfish   402 -RTLKILSVGLGDSSTPSPAHKLLQAPPSP---------------IRIEEPRLQPMG 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 16/41 (39%)
leucine-rich repeat 302..327 CDD:275381 4/26 (15%)
AMN1 309..480 CDD:187754 42/182 (23%)
leucine-rich repeat 328..352 CDD:275381 7/28 (25%)
leucine-rich repeat 353..376 CDD:275381 5/27 (19%)
leucine-rich repeat 377..402 CDD:275381 7/24 (29%)
leucine-rich repeat 403..428 CDD:275381 6/24 (25%)
leucine-rich repeat 429..455 CDD:275381 5/25 (20%)
leucine-rich repeat 456..480 CDD:275381 7/23 (30%)
leucine-rich repeat 481..500 CDD:275381 7/21 (33%)
leucine-rich repeat 506..529 CDD:275381 2/22 (9%)
fbxl5NP_001288257.1 Hemerythrin-like. /evidence=ECO:0000250 1..159
Hr_FBXL5 7..155 CDD:213984
F-box-like 208..252 CDD:289689 16/41 (39%)
AMN1 313..>410 CDD:187754 35/145 (24%)
LRR 1 316..342 6/34 (18%)
leucine-rich repeat 335..360 CDD:275381 7/24 (29%)
LRR 2 343..367 8/23 (35%)
leucine-rich repeat 361..387 CDD:275381 11/51 (22%)
LRR 3 368..395 13/52 (25%)
leucine-rich repeat 388..422 CDD:275381 13/42 (31%)
LRR 4 396..426 9/38 (24%)
leucine-rich repeat 423..447 CDD:275381 5/35 (14%)
leucine-rich repeat 510..574 CDD:275381
LRR 5 565..595
AMN1 566..>644 CDD:187754
leucine-rich repeat 588..615 CDD:275381
LRR 6 596..623
leucine-rich repeat 616..641 CDD:275381
LRR 7 624..649
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170588078
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.840

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