DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and Fbxl15

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:NP_001101073.1 Gene:Fbxl15 / 309453 RGDID:1306444 Length:300 Species:Rattus norvegicus


Alignment Length:260 Identity:68/260 - (26%)
Similarity:107/260 - (41%) Gaps:43/260 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   244 DEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQI---VRRGVLV- 304
            |.:|..:..|:|.:.|||:..|.|.|.         ..:.|.|..:|.....|:   :.|..|| 
  Rat    26 DVLLPHVLNWVPLRQLLRLQRVSRAFR---------ALV
QLHLARLRRFDAAQVGPQIPRAALVR 81

  Fly   305 -IRLAQTSIQEPAFAPYTE---------VFRTRLQYLDLSMA---SITRSSLLTLLSHCRQLKKI 356
             :|.|: .:||.|.||..|         |.....|...:::|   .::|.:|..|...|.:|::|
  Rat    82 LLRDAE-GLQELALAPCHEWLLDEDLVPVLARNPQLRSVALAGCGQLSRRALGALAEGCPRLQRI 145

  Fly   357 SLENIELDD--------DICAEIAKNEALEAVNLTMASGLTSNS-VRLMMESLTSLSSLNISWTD 412
            ||.:.:..|        |.|      .|||.::||....|...: |.|.......|.||:::...
  Rat   146 SLAHCDWVDGLALRGLADRC------PALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNA 204

  Fly   413 LSADAVTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMK 477
            ...|.....:....|.|..|::.||.||..|. |.||.:.||.|..|.:..|:.:....::.:.|
  Rat   205 NVGDTAVQELARNCPQLEHLDLTGCLRVGSDG-VRTLAEYCPALRSLRVRHCHHVAEPSLSRLRK 268

  Fly   478  477
              Rat   269  268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 10/39 (26%)
leucine-rich repeat 302..327 CDD:275381 11/35 (31%)
AMN1 309..480 CDD:187754 49/190 (26%)
leucine-rich repeat 328..352 CDD:275381 6/26 (23%)
leucine-rich repeat 353..376 CDD:275381 7/30 (23%)
leucine-rich repeat 377..402 CDD:275381 7/25 (28%)
leucine-rich repeat 403..428 CDD:275381 4/24 (17%)
leucine-rich repeat 429..455 CDD:275381 11/25 (44%)
leucine-rich repeat 456..480 CDD:275381 4/22 (18%)
leucine-rich repeat 481..500 CDD:275381
leucine-rich repeat 506..529 CDD:275381
Fbxl15NP_001101073.1 F-box 18..55 CDD:395521 10/37 (27%)
leucine-rich repeat 62..88 CDD:275381 7/26 (27%)
leucine-rich repeat 89..115 CDD:275381 7/25 (28%)
Interaction with SMURF1. /evidence=ECO:0000250 113..269 42/163 (26%)
leucine-rich repeat 116..141 CDD:275381 5/24 (21%)
AMN1 <139..>268 CDD:187754 36/135 (27%)
leucine-rich repeat 142..167 CDD:275381 7/30 (23%)
leucine-rich repeat 168..194 CDD:275381 7/25 (28%)
leucine-rich repeat 195..220 CDD:275381 4/24 (17%)
leucine-rich repeat 221..245 CDD:275381 10/24 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166346666
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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