DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and Fbxl19

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:XP_006230338.1 Gene:Fbxl19 / 308999 RGDID:1310989 Length:739 Species:Rattus norvegicus


Alignment Length:534 Identity:121/534 - (22%)
Similarity:186/534 - (34%) Gaps:148/534 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 RKHRGSENMENLCPVTRKRSTNKNHVSVVGALVSTTKSSHYEHPSSPSALTFEALE--------E 60
            ||.|...| |...|..:.:...:.|:..||......:.:   .|.||..|....|.        .
  Rat   259 RKEREGGN-EPPTPRKKVKGGRERHLKKVGGDACLLRGA---DPGSPGLLPPRVLNPSQAFSSCH 319

  Fly    61 MGIGMLDSEESSSSALSAIALAVSATSDDNSNETTPCASVSRMAHQLQHTQRL--SLGSTGDITL 123
            .|:...:.|:......||...||.:.|....       .:.|.....|..:|:  :..|:.|...
  Rat   320 PGLPPENWEKPKPPIASAEGPAVPSPSPQRE-------KLERFKRMCQLLERVPDTSSSSSDSDS 377

  Fly   124 DSPAVEDSLSMSRQSAEKLQILAQAKRSSLGSEGSGNSNSPSKRLR----NPLAAVTCNNQIDGT 184
            ||.:...|||......|    ....:|.:.||.|...:....:.:|    .||            
  Rat   378 DSDSSGTSLSEDEAPGE----ARNGRRPARGSSGEKENRGGRRAIRPGSGGPL------------ 426

  Fly   185 ASLNFQPSTSRLAQVRQAKKPSTTNITTRIVAADSFFVFRTPAMSAH-----INSGINYFERLSD 244
            .|....|          |..|....:...:|        |.|..|..     :.:|       ||
  Rat   427 LSWPLGP----------APPPRPPQLERHVV--------RPPPRSPEPDTLPLAAG-------SD 466

  Fly   245 EIL-----LDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLR-TIRPGALEQIVRRGVL 303
            ..|     |.:|:.|..:.|.....|||.::|...|:.||.|:||..| ::.|..|..:|||   
  Rat   467 HPLPRAAWLRVFQHLGPRELCVCMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRR--- 528

  Fly   304 VIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLEN-------- 360
                      :|             :.||||...:::..|:.||:..:.|:::.|..        
  Rat   529 ----------QP-------------RALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSA 570

  Fly   361 --------IELDDDICAEIAKNEALEAVNL---------TMASG--------------LTSNSVR 394
                    :.|.|....|..|:..|..:.|         |.:.|              ||..|:|
  Rat   571 LGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLR 635

  Fly   395 LMMESLTSLSSLNISWT----DLSADAVTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRCPQ 455
            |::.....||:|::|..    |.|...:||..:.:...|:.||:|||.|:  ..|...|.:|||:
  Rat   636 LLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRL--TDHCLPLFRRCPR 698

  Fly   456 LLELDLSDCNSLTP 469
            |..|||..|..|:|
  Rat   699 LRRLDLRSCRQLSP 712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 15/49 (31%)
leucine-rich repeat 302..327 CDD:275381 1/24 (4%)
AMN1 309..480 CDD:187754 50/204 (25%)
leucine-rich repeat 328..352 CDD:275381 7/23 (30%)
leucine-rich repeat 353..376 CDD:275381 6/38 (16%)
leucine-rich repeat 377..402 CDD:275381 9/47 (19%)
leucine-rich repeat 403..428 CDD:275381 8/28 (29%)
leucine-rich repeat 429..455 CDD:275381 11/25 (44%)
leucine-rich repeat 456..480 CDD:275381 7/14 (50%)
leucine-rich repeat 481..500 CDD:275381
leucine-rich repeat 506..529 CDD:275381
Fbxl19XP_006230338.1 zf-CXXC <95..122 CDD:251032
PHD_FXL19 132..193 CDD:277115
F-box-like 469..512 CDD:289689 14/42 (33%)
AMN1 511..710 CDD:187754 55/226 (24%)
leucine-rich repeat 531..554 CDD:275381 7/22 (32%)
leucine-rich repeat 555..578 CDD:275381 2/22 (9%)
leucine-rich repeat 616..643 CDD:275381 5/26 (19%)
leucine-rich repeat 644..670 CDD:275381 8/25 (32%)
leucine-rich repeat 674..698 CDD:275381 11/25 (44%)
leucine-rich repeat 699..723 CDD:275381 7/14 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166346681
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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