Protein Alignment Skp2 and Fbxl12

DIOPT Version :10

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001273458.1
• Gene: Fbxl12 / 30843
• MGIID: 1354738
• Length: 349
• Species: Mus musculus
• Alignment Length: 345
• Identity: 86/345 - (24%)
• Similarity: 135/345 - (39%)
• Gaps: 89/345 - (25%)

  Fly   245 EILLDI-FKW-------------LPKKTLLRM----ATVCRRFNRCSRDETLWTRLDLGLRTIRP 291
            |::|:| ..|             ||.:|:|..    ..||.|:.|...|..||..:||.|.|:||
Mouse    15 ELVLEIPSSWKKPKGSQRRGARLLPSQTILLPRNPGCRVCHRWKRLVDDRWLWRHVDLTLYTMRP 79

  Fly   292 GALEQIVRRGVLVIRLAQ--------TSIQEPAFAP---------YTEVFRTRLQYLDLSMASIT 339
            ..:..::|| .:..||..        :..|.|..:|         ...:.|..|...||||..||
Mouse    80 KVMWHLLRR-YMASRLYSLRMGGYLFSGSQAPQLSPALMRALGQKCPNLKRLCLHVADLSMVPIT 143

  Fly   340 R--SSLLTLLSHCRQLKKI------------SLENIELD------DDICAEIAKNEALEAVNLTM 384
            .  |:|.||..|..::..|            .||.|.||      |:....:.:..||.::.|..
Mouse   144 SLPSTLRTLELHSCEISMIWLQKEQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGG 208

  Fly   385 ASGLTSNSVRLMMESLTSLSSLNISWTDLSADA-VTALVTHI-SPNLIRLNIAG--CRRVLFDSH 445
            ...:|...:...::.|:.|..|.:....||||: :.|:..|: ....|||.:.|  .:.::|...
Mouse   209 TYRVTETGLDASLQELSYLQRLEVLGCTLSADSTLLAISRHLRDVRKIRLTVGGLSAQGLVFLEG 273

  Fly   446 VATLQKRCPQ--LLELDLSDCNSLTPTVITAIMKFKMLEYLSVSRCYLIPATKFIELKSMPSLTY 508
            :..|:..|.|  |:..|:.     |||.|             ||.|..:|..:.:|::.:
Mouse   274 MPVLESLCFQGPLITPDMP-----TPTQI-------------VSSCLTMPKLRVLEVQGL----- 315

  Fly   509 LDIFGMLSDTAMEVLEKQLP 528
                |.....|.::|.|.||
Mouse   316 ----GWEGQEAEKILCKGLP 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box_DmSKP2-like	239..281	CDD:438920	15/53 (28%)
		leucine-rich repeat	302..327	CDD:275381	6/41 (15%)
		AMN1	309..480	CDD:187754	50/213 (23%)
		leucine-rich repeat	328..352	CDD:275381	12/25 (48%)
		leucine-rich repeat	353..376	CDD:275381	7/40 (18%)
		leucine-rich repeat	377..402	CDD:275381	4/24 (17%)
		leucine-rich repeat	403..428	CDD:275381	8/26 (31%)
		leucine-rich repeat	429..455	CDD:275381	7/27 (26%)
		leucine-rich repeat	456..480	CDD:275381	6/23 (26%)
		leucine-rich repeat	481..500	CDD:275381	4/18 (22%)
		leucine-rich repeat	506..529	CDD:275381	6/23 (26%)
Fbxl12	NP_001273458.1	F-box_SF	<52..68	CDD:459239	6/15 (40%)
		leucine-rich repeat	127..148	CDD:275381	8/20 (40%)
		AMN1	144..>249	CDD:187754	24/104 (23%)
		leucine-rich repeat	149..175	CDD:275381	5/25 (20%)
		leucine-rich repeat	176..200	CDD:275381	6/23 (26%)
		leucine-rich repeat	201..226	CDD:275381	4/24 (17%)
		leucine-rich repeat	227..252	CDD:275381	8/24 (33%)
		leucine-rich repeat	253..276	CDD:275381	5/22 (23%)
		leucine-rich repeat	277..306	CDD:275381	12/46 (26%)