DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and Fbxl6

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_038937.2	Gene:	Fbxl6 / 30840	MGIID:	1354705	Length:	535	Species:	Mus musculus

Alignment Length:	362	Identity:	74/362 - (20%)
Similarity:	131/362 - (36%)	Gaps:	110/362 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 PAMSAHINSGINYFERLSDEILLDIFKWL-----PKKTLLRMATVCRRFNRCSRDETLWTRLDLG 285
            |::...::||  :.:|:..|:|:.||..|     |...|.|.|.|||.::..:...:||..:.|.
Mouse    93 PSLDQGLDSG--WGDRIPLEVLVHIFGLLVAAHGPMPFLGRAARVCRHWHEATSHPSLWHTVTLS 155

  Fly   286 ---------------------LRTIRPGALEQIVRRGVLVIRLAQTSIQEPAFAPYTEVFRTRLQ 329
                                 |..:.|....|:..     :.|.....|..:.......|..||.
Mouse   156 PSLVGRAGKGNLKGEKKLLACLEWLVPNRFSQLQS-----LTLIHWKSQVHSVLELVSKFCPRLT 215

  Fly   330 YLDLS-MASITRSSLLTLLSHCRQLKKISLENIELDDDICAEIAKNEALEAVNLTMASGLTSNSV 393
            :|.|| ..::|..:|:.|...|.||..:.|.:         .:.::.|:               |
Mouse   216 FLKLSDCHTVTAETLVMLARACCQLHSLDLHH---------SMVESTAV---------------V 256

  Fly   394 RLMMESLTSLSSLNISWTDLSADAVTALVTHISPNLIRLNIA---GCRRVLFDSHVATLQKRCPQ 455
            ..:.|:.:.:..|.::::..:...:.||:.:..|.|..|.::   .|........|..|||.|||
Mouse   257 SFLEEAGSRMRKLWLTYSSQTTAILGALLDNCCPQLQVLQVSTGMNCNNTPLQLPVEALQKGCPQ 321

  Fly   456 LLELDL------------------------------SDCNSLTPTVITAIM----KFKMLEYLSV 486
            |..|.|                              |.||.::..|:..::    |.:||:....
Mouse   322 LQVLRLLNLIWLPKPCGRGVPQGPGFPSLEELCLAGSTCNFVSNEVLGRLLHRSPKLRMLDLRGC 386

  Fly   487 SR------CYLIPATKFIELKSMPSLTYLDIFGMLSD 517
            :|      |:| |..:..:|       ||.::| :||
Mouse   387 ARVTPSGLCHL-PCQELEQL-------YLGLYG-ISD 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	15/49 (31%)
		leucine-rich repeat	302..327	CDD:275381	3/24 (13%)
		AMN1	309..480	CDD:187754	39/208 (19%)
		leucine-rich repeat	328..352	CDD:275381	8/24 (33%)
		leucine-rich repeat	353..376	CDD:275381	2/22 (9%)
		leucine-rich repeat	377..402	CDD:275381	2/24 (8%)
		leucine-rich repeat	403..428	CDD:275381	3/24 (13%)
		leucine-rich repeat	429..455	CDD:275381	8/28 (29%)
		leucine-rich repeat	456..480	CDD:275381	8/57 (14%)
		leucine-rich repeat	481..500	CDD:275381	5/24 (21%)
		leucine-rich repeat	506..529	CDD:275381	5/12 (42%)
Fbxl6	NP_038937.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..99		1/5 (20%)
		F-box-like	105..155	CDD:289689	15/49 (31%)
		LRR 1	169..195		4/30 (13%)
		AMN1	171..390	CDD:187754	46/247 (19%)
		leucine-rich repeat	188..213	CDD:275381	3/29 (10%)
		LRR 2	196..221		6/24 (25%)
		leucine-rich repeat	214..239	CDD:275381	8/24 (33%)
		LRR 3	222..247		7/24 (29%)
		leucine-rich repeat	240..291	CDD:275381	8/74 (11%)
		LRR 4	273..299		5/25 (20%)
		leucine-rich repeat	292..321	CDD:275381	8/28 (29%)
		LRR 5	304..329		10/24 (42%)
		leucine-rich repeat	322..349	CDD:275381	3/26 (12%)
		LRR 6	330..357		0/26 (0%)
		AMN1	<349..500	CDD:187754	17/75 (23%)
		leucine-rich repeat	350..377	CDD:275381	4/26 (15%)
		LRR 7	360..385		6/24 (25%)
		leucine-rich repeat	378..401	CDD:275381	6/23 (26%)
		LRR 8	386..411		7/32 (22%)
		LRR 9	415..441		74/362 (20%)
		leucine-rich repeat	434..466	CDD:275381
		leucine-rich repeat	467..491	CDD:275381
		LRR 10	474..499
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843075
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940