Protein Alignment Skp2 and Skp2

DIOPT Version :10

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001099886.1
• Gene: Skp2 / 294790
• RGDID: 1562456
• Length: 423
• Species: Rattus norvegicus
• Alignment Length: 448
• Identity: 140/448 - (31%)
• Similarity: 232/448 - (51%)
• Gaps: 49/448 - (10%)

  Fly   120 DITLDSPAVEDSLSMSRQSAEKLQILAQAKRSSLGSEGSGNSNSPSKRLRN---PLAAVTCNNQI 181
            :|...|..|..|.:....|::..::|:....|:|..|...:.|.|...|.|   |.:
  Rat     8 EIPDQSSNVTTSFTWGWDSSKTSELLSGMGVSALEKEEVDSENIPHGLLSNLGHPQS-------- 64

  Fly   182 DGTASLNFQPSTSRLAQVRQAKKPSTTNITTRIVAADSFFVFRTPAMSAHINSGINYFERLSDEI 246
                     |...||......|               .|.:.|.|.::.....|::: :.|.||:
  Rat    65 ---------PPRKRLKSKGSDK---------------DFVIIRRPKLNRENFPGVSW-DSLPDEL 104

  Fly   247 LLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGVLVIRLAQTS 311
            ||.||..|....|||::.||:|:.|.|.||:||..|||..:.:.|....:::.|||:..|..::.
  Rat   105 LLGIFSCLCLPELLRVSGVCKRWYRLSLDESLWQSLDLAGKNLHPDVTVRLLSRGVVAFRCPRSF 169

  Fly   312 IQEP---AFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLENIELDDDICAEIAK 373
            :::|   :|:.:      |:|::|||.:.|..|:|..:||.|.:|:.:|||.::|.|.|...:|:
  Rat   170 MEQPLGESFSSF------RVQHMDLSNSVINVSNLHGILSECSKLQNLSLEGLQLSDPIVTTLAQ 228

  Fly   374 NEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWT-DLSADAVTALVTHISPNLIRLNIAGC 437
            ||.|..:||...||.:.::|..::.|.:.|..||:||. |.:...|.|.|.|:...|.:||::|.
  Rat   229 NENLVRLNLCGCSGFSESAVATLLSSCSRLDELNLSWCFDFTEKHVQAAVAHLPDTLTQLNLSGY 293

  Fly   438 RRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMKFKMLEYLSVSRCY-LIPATKFIELK 501
            |:.|..:.:.||.||||.|:.|||||...|.........:...|::||:|||| :||.| .:||.
  Rat   294 RKNLQKTDLCTLIKRCPNLVRLDLSDSIMLKNDCFPEFFQLNYLQHLSLSRCYDIIPET-LLELG 357

  Fly   502 SMPSLTYLDIFGMLSDTAMEVLEKQLPKMGINKFIHSSVSRPTVGTRRT-SIWGLRTR 558
            .:|:|..|.:||::.|..:::|.:.||::.||....:|::|||:..::. .|||::.|
  Rat   358 EIPTLKTLQVFGIVPDGTLQLLREALPRLQINCAYFTSIARPTMDNKKNPEIWGIKCR 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box_DmSKP2-like	239..281	CDD:438920	20/41 (49%)
		leucine-rich repeat	302..327	CDD:275381	4/27 (15%)
		AMN1	309..480	CDD:187754	59/174 (34%)
		leucine-rich repeat	328..352	CDD:275381	10/23 (43%)
		leucine-rich repeat	353..376	CDD:275381	9/22 (41%)
		leucine-rich repeat	377..402	CDD:275381	7/24 (29%)
		leucine-rich repeat	403..428	CDD:275381	10/25 (40%)
		leucine-rich repeat	429..455	CDD:275381	11/25 (44%)
		leucine-rich repeat	456..480	CDD:275381	7/23 (30%)
		leucine-rich repeat	481..500	CDD:275381	10/19 (53%)
		leucine-rich repeat	506..529	CDD:275381	7/22 (32%)
Skp2	NP_001099886.1	F-box_FBXL1	97..137	CDD:438886	8/39 (21%)
		leucine-rich repeat	137..167	CDD:275381	13/29 (45%)
		leucine-rich repeat	183..207	CDD:275381	6/26 (23%)
		AMN1	193..>345	CDD:187754	53/155 (34%)
		leucine-rich repeat	208..231	CDD:275381	7/22 (32%)
		leucine-rich repeat	232..257	CDD:275381	10/24 (42%)
		leucine-rich repeat	258..283	CDD:275381	9/24 (38%)
		leucine-rich repeat	285..311	CDD:275381	9/26 (35%)
		leucine-rich repeat	312..336	CDD:275381	7/23 (30%)
		leucine-rich repeat	337..356	CDD:275381	11/18 (61%)