DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and Skp2

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_011243661.1	Gene:	Skp2 / 27401	MGIID:	1351663	Length:	434	Species:	Mus musculus

Alignment Length:	457	Identity:	137/457 - (29%)
Similarity:	239/457 - (52%)	Gaps:	51/457 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 QHTQRLSLGSTGDITLDSPAVEDSLSMSRQSAEKLQILAQAKRSSLGSEGSGNSNSPSKRLRNPL 172
            :|.|.:. ..:|::|       .|.:....|::..::|:....|:|..|...:.|.|...|.|
Mouse    14 KHLQEIP-DQSGNVT-------TSFTWGWDSSKTSELLSGMGVSALEKEEVDSENIPHGLLSN-- 68

  Fly   173 AAVTCNNQIDGTASLNFQPSTSRLAQVRQAKKPSTTNITTRIVAADSFFVFRTPAMSAHINSGIN 237
                          |....|..|    ::.|...:..         .|.:.|.|.:|.....|::
Mouse    69 --------------LGHPQSPPR----KRVKGKGSDK---------DFVIIRRPKLSRENFPGVS 106

  Fly   238 YFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGV 302
            : :.|.||:||.||..|....|||::.||:|:.|.|.||:||..|||..:.:.|....:::.|||
Mouse   107 W-DSLPDELLLGIFSCLCLPELLRVSGVCKRWYRLSLDESLWQSLDLAGKNLHPDVTVRLLSRGV 170

  Fly   303 LVIRLAQTSIQEP---AFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLENIELD 364
            :..|..::.:::|   :|:.:      |:|::|||.:.|..|:|..:||.|.:|:.:|||.::|.
Mouse   171 VAFRCPRSFMEQPLGESFSSF------RVQHMDLSNSVINVSNLHKILSECSKLQNLSLEGLQLS 229

  Fly   365 DDICAEIAKNEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWT-DLSADAVTALVTHISPN 428
            |.|...:|:||.|..:||...||.:.::|..::.|.:.|..||:||. |.:...|.|.|.|:...
Mouse   230 DPIVKTLAQNENLVRLNLCGCSGFSESAVATLLSSCSRLDELNLSWCFDFTEKHVQAAVAHLPNT 294

  Fly   429 LIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMKFKMLEYLSVSRCY-LI 492
            :.:||::|.|:.|..:.:.|:.||||.|:.|||||...|.........:...|::||:|||| :|
Mouse   295 ITQLNLSGYRKNLQKTDLCTIIKRCPNLIRLDLSDSIMLKNDCFPEFFQLNYLQHLSLSRCYDII 359

  Fly   493 PATKFIELKSMPSLTYLDIFGMLSDTAMEVLEKQLPKMGINKFIHSSVSRPTVGTRRT-SIWGLR 556
            |.| .:||..:|:|..|.:||::.:..:::|.:.||::.||....::::|||:.:::. .|||::
Mouse   360 PDT-LLELGEIPTLKTLQVFGIVPEGTLQLLREALPRLQINCAYFTTIARPTMDSKKNLEIWGIK 423

  Fly   557 TR 558
            .|
Mouse   424 CR 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	21/44 (48%)
		leucine-rich repeat	302..327	CDD:275381	4/27 (15%)
		AMN1	309..480	CDD:187754	57/174 (33%)
		leucine-rich repeat	328..352	CDD:275381	10/23 (43%)
		leucine-rich repeat	353..376	CDD:275381	9/22 (41%)
		leucine-rich repeat	377..402	CDD:275381	7/24 (29%)
		leucine-rich repeat	403..428	CDD:275381	10/25 (40%)
		leucine-rich repeat	429..455	CDD:275381	9/25 (36%)
		leucine-rich repeat	456..480	CDD:275381	7/23 (30%)
		leucine-rich repeat	481..500	CDD:275381	10/19 (53%)
		leucine-rich repeat	506..529	CDD:275381	6/22 (27%)
Skp2	XP_011243661.1	F-box-like	107..151	CDD:372399	7/43 (16%)
		leucine-rich repeat	147..177	CDD:275381	14/29 (48%)
		leucine-rich repeat	193..217	CDD:275381	5/23 (22%)
		AMN1	203..>355	CDD:187754	49/155 (32%)
		leucine-rich repeat	218..241	CDD:275381	6/25 (24%)
		leucine-rich repeat	242..267	CDD:275381	10/24 (42%)
		leucine-rich repeat	268..293	CDD:275381	9/24 (38%)
		leucine-rich repeat	295..321	CDD:275381	8/26 (31%)
		leucine-rich repeat	322..346	CDD:275381	8/23 (35%)
		leucine-rich repeat	347..366	CDD:275381	7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843089
Domainoid	1	1.000	164	1.000	Domainoid score	I3934
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55942
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3663
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005610
OrthoInspector	1	1.000	-	-		oto92087
orthoMCL	1	0.900	-	-		OOG6_109192
Panther	1	1.100	-	-	LDO	PTHR16134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5156
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.920