DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and FBXL5

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_036293.1	Gene:	FBXL5 / 26234	HGNCID:	13602	Length:	691	Species:	Homo sapiens

Alignment Length:	268	Identity:	53/268 - (19%)
Similarity:	100/268 - (37%)	Gaps:	77/268 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 MSAHINSGINYFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLW------------- 279
            :|.| ::||.:   |..|::|.||.:|..:.|.|.:.|..::::.::..:||
Human   198 VSEH-STGITH---LPPEVMLSIFSYLNPQELCRCSQVSMKWSQLTKTGSLWKHLYPVHWARGDW 258

  Fly   280 -----TRLDLGLRTIRPGALEQIVRRGVLVIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASIT 339
                 |.||     ..|.. |.:..|          ..:..||..:.|         |..:....
Human   259 YSGPATELD-----TEPDD-EWVKNR----------KDESRAFHEWDE---------DADIDESE 298

  Fly   340 RSSLLTLLSHCRQLKKISLENIELDDDICAEIAKNEALEAVNLTMASGLTSNSVRLMMESLTSLS 404
            .|:..::.....|::|..|..  |..::...:  ..:::.:.|..:|.::|..||.::|...:|.
Human   299 ESAEESIAISIAQMEKRLLHG--LIHNVLPYV--GTSVKTLVLAYSSAVSSKMVRQILELCPNLE 359

  Fly   405 SLNISWTDLSADAVTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTP 469
            .|:::.||:|..|..:           .:..||               |..|..||||.|..:|.
Human   360 HLDLTQTDISDSAFDS-----------WSWLGC---------------CQSLRHLDLSGCEKITD 398

  Fly   470 TVITAIMK 477
            ..:..|.:
Human   399 VALEKISR 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	13/62 (21%)
		leucine-rich repeat	302..327	CDD:275381	3/24 (13%)
		AMN1	309..480	CDD:187754	32/169 (19%)
		leucine-rich repeat	328..352	CDD:275381	2/23 (9%)
		leucine-rich repeat	353..376	CDD:275381	3/22 (14%)
		leucine-rich repeat	377..402	CDD:275381	6/24 (25%)
		leucine-rich repeat	403..428	CDD:275381	6/24 (25%)
		leucine-rich repeat	429..455	CDD:275381	3/25 (12%)
		leucine-rich repeat	456..480	CDD:275381	8/22 (36%)
		leucine-rich repeat	481..500	CDD:275381
		leucine-rich repeat	506..529	CDD:275381
FBXL5	NP_036293.1	Hemerythrin-like	1..159
		Hr_FBXL5	7..160	CDD:213984
		F-box-like	205..249	CDD:289689	12/46 (26%)
		leucine-rich repeat	332..357	CDD:275381	6/24 (25%)
		LRR 1	340..364		7/23 (30%)
		AMN1	354..>408	CDD:187754	17/79 (22%)
		leucine-rich repeat	358..384	CDD:275381	9/51 (18%)
		LRR 2	365..392		11/52 (21%)
		leucine-rich repeat	385..435	CDD:275381	8/22 (36%)
		LRR 3	393..418		3/14 (21%)
		leucine-rich repeat	436..500	CDD:275381
		LRR 4	479..508
		leucine-rich repeat	501..537	CDD:275381
		leucine-rich repeat	538..583	CDD:275381
		LRR 5	576..607
		leucine-rich repeat	584..627	CDD:275381
		AMN1	<603..>654	CDD:187754
		LRR 6	608..635
		leucine-rich repeat	628..653	CDD:275381
		LRR 7	636..661
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153056
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930