DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and FBXL6

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_036294.2	Gene:	FBXL6 / 26233	HGNCID:	13603	Length:	539	Species:	Homo sapiens

Alignment Length:	517	Identity:	96/517 - (18%)
Similarity:	160/517 - (30%)	Gaps:	194/517 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 QSAEKLQILAQAKRSSLGSEGSGNSNSPSKRLRNPLAAVTCNNQIDGTASLNFQPSTSRLAQVRQ 201
            ||...|.:|::...:...::...:..:|.:..|.|.||.              :|.....::...
Human    41 QSDSMLLVLSEPGPARPRAQRRASRRTPRQPPRGPSAAA--------------KPKAGLRSEAAA 91

  Fly   202 AKKPSTTNITTRIVAADSFFVFRTPAMSAHINSGINYFERLSDEILLDIFKWL-----PKKTLLR 261
            |..|:..               .||......::|  :.:|:..|||:.||..|     |...|.|
Human    92 APAPAPA---------------PTPTPEEGPDAG--WGDRIPLEILVQIFGLLVAADGPMPFLGR 139

  Fly   262 MATVCRRFNRCSRDETLWTRLDL---------------------GLRTIRPGALEQIVRRGVL-- 303
            .|.||||:...:....||..:.|                     .|..:.|....|:.|..::
Human   140 AARVCRRWQEAASQPALWHTVTLSSPLVGRPAKGGVKAEKKLLASLEWLMPNRFSQLQRLTLIHW 204

  Fly   304 ------VIRLAQTSIQEPAFAPYTEVFRTRLQYLDLS-MASITRSSLLTLLSHCRQLKKISLENI 361
                  |::|.....             .||.:|.|| ...:|..:|:.|...|.||..:.|::.
Human   205 KSQVHPVLKLVGECC-------------PRLTFLKLSGCHGVTADALVMLAKACCQLHSLDLQHS 256

  Fly   362 ELDD----------------------------------DICAEIAKNEALEAVNLTMASGLTSNS 392
            .::.                                  ..|.::   :.||     :::|:..||
Human   257 MVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLGSCCPQL---QVLE-----VSTGINRNS 313

  Fly   393 VRLMM---------ESLTSLSSLNISW---------------------------TDLSADAVTAL 421
            :.|.:         ..|..|..||:.|                           .:..::.|...
Human   314 IPLQLPVEALQKGCPQLQVLRLLNLMWLPKPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGR 378

  Fly   422 VTHISPNLIRLNIAGCRRV------------LFDSHVA--------TL---------QKRCPQLL 457
            :.|.||||..|::.||.|:            |...|:.        ||         ||.|..|.
Human   379 LLHGSPNLRLLDLRGCARITPAGLQDLPCRELEQLHLGLYGTSDRLTLAKEGSPFLTQKWCHTLR 443

  Fly   458 ELDLSDCNSLTPTVITAIMKF--------KMLEYLSVSRCYLIPATKFIELKSMPSLTYLDI 511
            |||||........:..|:..|        ..|..|::....:.|:|....:...|.|.||::
Human   444 ELDLSGQGFSEKDLEQALAAFLSTPGGSHPALCSLNLRGTRVTPSTVSSVISGCPGLLYLNL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	17/49 (35%)
		leucine-rich repeat	302..327	CDD:275381	2/32 (6%)
		AMN1	309..480	CDD:187754	49/278 (18%)
		leucine-rich repeat	328..352	CDD:275381	8/24 (33%)
		leucine-rich repeat	353..376	CDD:275381	3/56 (5%)
		leucine-rich repeat	377..402	CDD:275381	7/33 (21%)
		leucine-rich repeat	403..428	CDD:275381	7/51 (14%)
		leucine-rich repeat	429..455	CDD:275381	12/54 (22%)
		leucine-rich repeat	456..480	CDD:275381	8/31 (26%)
		leucine-rich repeat	481..500	CDD:275381	4/18 (22%)
		leucine-rich repeat	506..529	CDD:275381	3/6 (50%)
FBXL6	NP_036294.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..111		12/92 (13%)
		F-box-like	113..163	CDD:289689	17/49 (35%)
		LRR 1	177..203		4/25 (16%)
		AMN1	185..398	CDD:187754	40/233 (17%)
		leucine-rich repeat	196..221	CDD:275381	3/37 (8%)
		LRR 2	204..229		6/37 (16%)
		leucine-rich repeat	222..247	CDD:275381	8/24 (33%)
		LRR 3	230..255		7/24 (29%)
		leucine-rich repeat	248..299	CDD:275381	3/50 (6%)
		LRR 4	281..307		3/33 (9%)
		leucine-rich repeat	300..329	CDD:275381	6/36 (17%)
		LRR 5	312..337		5/24 (21%)
		leucine-rich repeat	330..357	CDD:275381	5/26 (19%)
		LRR 6	341..365		0/23 (0%)
		AMN1	<357..508	CDD:187754	33/149 (22%)
		leucine-rich repeat	358..385	CDD:275381	3/26 (12%)
		LRR 7	368..393		7/24 (29%)
		leucine-rich repeat	386..409	CDD:275381	5/22 (23%)
		LRR 8	394..419		4/24 (17%)
		LRR 9	423..449		10/25 (40%)
		leucine-rich repeat	442..474	CDD:275381	8/31 (26%)
		LRR 10	453..481		4/27 (15%)
		leucine-rich repeat	475..499	CDD:275381	4/23 (17%)
		LRR 11	482..507		6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940