DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Skp2 and Lrrc29

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001355337.1	Gene:	Lrrc29 / 234684	MGIID:	2443262	Length:	621	Species:	Mus musculus

Alignment Length:	626	Identity:	125/626 - (19%)
Similarity:	218/626 - (34%)	Gaps:	172/626 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RSTN-KNHVSVVGALVSTTKSSHYEHPSSPSALTFEALEEMGIGMLDSEESSSSALSAIALAVSA 85
            |.|| :.::.|..|.:|..||           |....:..:.:..||...:|...|.::|.
Mouse    41 RETNVRYNIPVSSASLSAIKS-----------LGLRGISCISLTNLDGSPASHQVLQSVAY---- 90

  Fly    86 TSDDNSNETTPCASVSRMAHQLQHTQRLSLGSTGDITLDSPAVEDSLSMSRQSAEKLQILAQAKR 150
                               |...|.:.|.||.      .||.....|::         ||.....
Mouse    91 -------------------HLGPHLESLCLGG------GSPTEASFLAL---------ILGCPVL 121

  Fly   151 SSLGSEGSGNSNSPSKRLRNPLAAVTCNNQIDGTASLNFQPSTSRLAQVRQAKKPSTTNITT--- 212
            .:|...|..:..:....|..|..|......:.|...||       ||.:|.....|..::::
Mouse   122 RTLDLSGCNSLFTSGTLLAQPETAQCVREALSGLRDLN-------LAGLRDLTDLSFNHLSSCFP 179

  Fly   213 ---RIVAADSFFVFRTPAMSAHINSGINYFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSR 274
               |:..|.....|........|:..::...:||...||...|                    .|
Mouse   180 SLERLSLAYCHLSFELSPTWGSISPQVSSPSQLSFHNLLKFIK--------------------ER 224

  Fly   275 DETLWTRLDLGLRTIRPGALEQIVR-RGVLVIRLAQTSIQEPAFAPYTEVFRTR--LQYLDLSMA 336
            ..|| ..|||....:.|.||:.:.: .|:.:..|...|.::.:....|.:.|.:  |..||||..
Mouse   225 AGTL-RALDLSGTGLPPEALQALGQVTGLKLEELYLHSCRDLSSEAVTILCRQQPGLTSLDLSGC 288

  Fly   337 S-ITRSSLLTLLSHCRQLKKISLENIE-LDDDICAEIAKNEALEAVNLTMASGLTSNSVRLMMES 399
            | :|..:||.:....|.|:.:||:.:: |.|..||.:.....|:::::.....::...:..::.|
Mouse   289 SDLTDGALLAVSRGLRHLRHLSLKKLQRLTDAGCAALGALRELQSLDMAECCLVSGRELAQVLGS 353

  Fly   400 L----TSLSSLNISWTDLSADA-VTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRC------ 453
            :    .:|:||.:::.....|| |.:::..:.|:|..|:::.|..:...    |:|..|
Mouse   354 VRRAPRALTSLRLAYCSSLKDASVLSMIPALGPSLKVLDLSSCMALTNQ----TMQAICTYLIHL 414

  Fly   454 -------------------------------------------------PQ---------LLELD 460
                                                             ||         |.|||
Mouse   415 SVLRLAWCKELQDWGLLGLKEPSDEPVLSPQLHQKVDNEAPDPQEPSSEPQGSSLLMLQALQELD 479

  Fly   461 LSDCNSLTPTVITAIMKFKMLEYLSVSRCYLIPA---TKFIEL-KSMPSLTYLDI--FGMLSDTA 519
            |:.|:.||...:..:::|..|..||:|   |:||   |..:.: :..|||..|.:  ...|||..
Mouse   480 LTACSKLTDASLAKVLQFPQLRQLSLS---LLPAFTDTGLVAVARGCPSLERLTLSHCSHLSDEG 541

  Fly   520 MEVLEKQLPKM-GINKFIHSSVSRPTVGTRRTSIWGLRTRD 559
            .....:..|:: .:|....|.::..|:.|...:...||..|
Mouse   542 WAQAARLWPRLQHLNLSSCSQLTEQTLDTIGQACKQLRVLD 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	9/44 (20%)
		leucine-rich repeat	302..327	CDD:275381	4/24 (17%)
		AMN1	309..480	CDD:187754	46/243 (19%)
		leucine-rich repeat	328..352	CDD:275381	9/24 (38%)
		leucine-rich repeat	353..376	CDD:275381	7/23 (30%)
		leucine-rich repeat	377..402	CDD:275381	2/28 (7%)
		leucine-rich repeat	403..428	CDD:275381	6/25 (24%)
		leucine-rich repeat	429..455	CDD:275381	6/80 (8%)
		leucine-rich repeat	456..480	CDD:275381	9/23 (39%)
		leucine-rich repeat	481..500	CDD:275381	8/21 (38%)
		leucine-rich repeat	506..529	CDD:275381	5/24 (21%)
Lrrc29	NP_001355337.1	F-box-like	3..38	CDD:372399
		leucine-rich repeat	70..83	CDD:275381	3/12 (25%)
		LRR_RI	<118..360	CDD:393385	54/269 (20%)
		leucine-rich repeat	121..154	CDD:275381	5/32 (16%)
		leucine-rich repeat	155..180	CDD:275381	6/31 (19%)
		leucine-rich repeat	181..227	CDD:275381	10/65 (15%)
		leucine-rich repeat	228..248	CDD:275381	7/20 (35%)
		AMN1	240..428	CDD:187754	40/191 (21%)
		leucine-rich repeat	254..277	CDD:275381	4/22 (18%)
		leucine-rich repeat	280..305	CDD:275381	9/24 (38%)
		leucine-rich repeat	306..360	CDD:275381	9/53 (17%)
		leucine-rich repeat	331..356	CDD:275381	2/24 (8%)
		leucine-rich repeat	361..387	CDD:275381	6/25 (24%)
		leucine-rich repeat	388..413	CDD:275381	6/28 (21%)
		leucine-rich repeat	414..474	CDD:275381	2/59 (3%)
		AMN1	<475..589	CDD:187754	32/111 (29%)
		leucine-rich repeat	475..525	CDD:275381	17/52 (33%)
		leucine-rich repeat	526..551	CDD:275381	5/24 (21%)
		leucine-rich repeat	552..577	CDD:275381	4/24 (17%)
		leucine-rich repeat	578..603	CDD:275381	3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840