DRSC/TRiP Functional Genomics Resources

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Protein Alignment Skp2 and Fbxl19

DIOPT Version :9

Sequence 1:NP_730815.2 Gene:Skp2 / 40548 FlyBaseID:FBgn0037236 Length:559 Species:Drosophila melanogaster
Sequence 2:XP_036008913.1 Gene:Fbxl19 / 233902 MGIID:3039600 Length:696 Species:Mus musculus


Alignment Length:530 Identity:123/530 - (23%)
Similarity:187/530 - (35%) Gaps:140/530 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 RKHRGSENMENLCPVTRKRSTNKNHVSVVGALVSTTKSSHYEHPSSPSALTFEALE--------E 60
            ||.|...| |...|..:.:...:.|:..||......:.:   .|.||..|....|.        .
Mouse   216 RKEREGGN-EPPTPRKKVKGGRERHLKKVGGDACLLRGA---DPGSPGLLPPRVLNPSQAFSSCH 276

  Fly    61 MGIGMLDSEESSSSALSAIALAVSATSDDNSNETTPCASVSRMAHQLQHTQRL--SLGSTGDITL 123
            .|:...:.|:......||...||.:.|....       .:.|.....|..:|:  :..|:.|...
Mouse   277 PGLPPENWEKPKPPIASAEGPAVPSPSPQRE-------KLERFKRMCQLLERVPDTSSSSSDSDS 334

  Fly   124 DSPAVEDSLSMSRQSAEKLQILAQAKRSSLGSEGSGNSNSPSKRLRNPLAAVTCNNQIDGTASLN 188
            ||.:...|||......|    ....:|.:.||.|. ..|...:|...|           ||..  
Mouse   335 DSDSSGTSLSEDEAPGE----ARNGRRPARGSSGE-KENRGGRRAIRP-----------GTGG-- 381

  Fly   189 FQPSTSRLAQVRQAKKPSTTNITTRIVAADSFFVFRTPAMSAH-----INSGINYFERLSDEIL- 247
              |..|  ..:..|..|....:...:|        |.|..|..     :.:|       ||..| 
Mouse   382 --PLLS--WPLGPAPPPRPPQLERHVV--------RPPPRSPEPDTLPLAAG-------SDHPLP 427

  Fly   248 ----LDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLR-TIRPGALEQIVRRGVLVIRL 307
                |.:|:.|..:.|.....|||.::|...|:.||.|:||..| ::.|..|..:|||       
Mouse   428 RAAWLRVFQHLGPRELCVCMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRR------- 485

  Fly   308 AQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLEN------------ 360
                  :|             :.||||...:::..|:.||:..:.|:::.|..            
Mouse   486 ------QP-------------RALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSA 531

  Fly   361 ----IELDDDICAEIAKNEALEAVNL---------TMASG--------------LTSNSVRLMME 398
                :.|.|....|..|:..|..:.|         |.:.|              ||..|:||::.
Mouse   532 PLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLR 596

  Fly   399 SLTSLSSLNISWT----DLSADAVTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRCPQLLEL 459
            ....||:|::|..    |.|...:||..:.:...|:.||:|||.|:  ..|...|.:|||:|..|
Mouse   597 HAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRL--TDHCLPLFRRCPRLRRL 659

  Fly   460 DLSDCNSLTP 469
            ||..|..|:|
Mouse   660 DLRSCRQLSP 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Skp2NP_730815.2 F-box-like 239..284 CDD:289689 15/49 (31%)
leucine-rich repeat 302..327 CDD:275381 1/24 (4%)
AMN1 309..480 CDD:187754 50/204 (25%)
leucine-rich repeat 328..352 CDD:275381 7/23 (30%)
leucine-rich repeat 353..376 CDD:275381 6/38 (16%)
leucine-rich repeat 377..402 CDD:275381 9/47 (19%)
leucine-rich repeat 403..428 CDD:275381 8/28 (29%)
leucine-rich repeat 429..455 CDD:275381 11/25 (44%)
leucine-rich repeat 456..480 CDD:275381 7/14 (50%)
leucine-rich repeat 481..500 CDD:275381
leucine-rich repeat 506..529 CDD:275381
Fbxl19XP_036008913.1 zf-CXXC <52..79 CDD:366873
PHD_FXL19 89..150 CDD:277115
F-box-like 426..467 CDD:403981 13/40 (33%)
AMN1 468..667 CDD:187754 55/226 (24%)
leucine-rich repeat 488..511 CDD:275381 7/22 (32%)
leucine-rich repeat 512..535 CDD:275381 2/22 (9%)
leucine-rich repeat 573..600 CDD:275381 5/26 (19%)
leucine-rich repeat 601..627 CDD:275381 8/25 (32%)
leucine-rich repeat 631..655 CDD:275381 11/25 (44%)
leucine-rich repeat 656..680 CDD:275381 7/14 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167843175
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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