Protein Alignment Skp2 and FBXL7

DIOPT Version :10

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_036436.1
• Gene: FBXL7 / 23194
• HGNCID: 13604
• Length: 491
• Species: Homo sapiens
• Alignment Length: 439
• Identity: 105/439 - (23%)
• Similarity: 172/439 - (39%)
• Gaps: 106/439 - (24%)

  Fly   154 GSEGSGNS-----------NSPSKRLRN----------------PLAAVTC--------NNQIDG 183
            ||||.|:|           ::|:|..:|                |..|:.|        |.:...
Human    10 GSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSS 74

  Fly   184 TASLNFQPSTSRLAQVRQAKKPSTTNITTRIVAADSFFVFRTPAMSAHINSGINYFERLSDEILL 248
            |:|.:....|     |.....|..|.:|..::...|    |.....|.|       :||.|..::
Human    75 TSSSSITGET-----VAMVHSPPPTRLTHPLIRLAS----RPQKEQASI-------DRLPDHSMV 123

  Fly   249 DIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGVLVIRLAQTSIQ 313
            .||.:||...|.|.|.||||:...:.|..||..:.|...||.   :::.::  ||..||.|.
Human   124 QIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETIN---VDRALK--VLTRRLCQD--- 180

  Fly   314 EPAFAPYTEVFRTRLQYLDLS-MASITRSSLLTLLSHCRQLKKISLENIELDDDICAEIAKNEA- 376
                   |......|:.:.:| ...:|...|.|:...|.:|:::.:..       |..|: |||
Human   181 -------TPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSG-------CYNIS-NEAV 230

  Fly   377 ---------LEAVNLTMASGLTSNSVRLMMESLTSLSSLN--------ISWTD---LSADAVTAL 421
                     ||.::::..|.:|  .:.|..|:...||.|:        :..||   |..:.:..:
Human   231 FDVVSLCPNLEHLDVSGCSKVT--CISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTI 293

  Fly   422 VTHISPNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCNSLTPTVITAIMKFK-MLEYLS 485
            ..|.: .|..|.:..|.| |.|..:..|...|..:.||.:|||..::...:..|.|.: .|.|||
Human   294 AAHCT-QLTHLYLRRCVR-LTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLS 356

  Fly   486 VSRCYLIP--ATKFIELKSMPSLTYLDIFGM--LSDTAMEVLEKQLPKM 530
            ::.|..:.  ..::: .|....|.||:..|.  ::|..:|.|.|...|:
Human   357 IAHCGRVTDVGIRYV-AKYCSKLRYLNARGCEGITDHGVEYLAKNCTKL 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box_DmSKP2-like	239..281	CDD:438920	17/41 (41%)
		leucine-rich repeat	302..327	CDD:275381	6/24 (25%)
		AMN1	309..480	CDD:187754	42/193 (22%)
		leucine-rich repeat	328..352	CDD:275381	6/24 (25%)
		leucine-rich repeat	353..376	CDD:275381	4/22 (18%)
		leucine-rich repeat	377..402	CDD:275381	6/24 (25%)
		leucine-rich repeat	403..428	CDD:275381	7/35 (20%)
		leucine-rich repeat	429..455	CDD:275381	8/25 (32%)
		leucine-rich repeat	456..480	CDD:275381	7/24 (29%)
		leucine-rich repeat	481..500	CDD:275381	5/20 (25%)
		leucine-rich repeat	506..529	CDD:275381	8/24 (33%)
FBXL7	NP_036436.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..79		15/68 (22%)
		F-box_FBXL7	114..157	CDD:438892	18/49 (37%)
		leucine-rich repeat	129..151	CDD:275381	9/21 (43%)
		leucine-rich repeat	154..187	CDD:275381	10/47 (21%)
		LRR 1	170..195		7/36 (19%)
		AMN1	<185..366	CDD:187754	45/192 (23%)
		leucine-rich repeat	188..213	CDD:275381	6/24 (25%)
		LRR 2	196..221		5/24 (21%)
		leucine-rich repeat	214..234	CDD:275381	6/27 (22%)
		LRR 3	222..247		7/25 (28%)
		leucine-rich repeat	240..273	CDD:275381	9/34 (26%)
		LRR 4	253..281		5/27 (19%)
		leucine-rich repeat	274..299	CDD:275381	4/25 (16%)
		LRR 5	282..307		4/25 (16%)
		AMN1	297..464	CDD:187754	30/111 (27%)
		leucine-rich repeat	300..325	CDD:275381	8/25 (32%)
		LRR 6	308..333		8/25 (32%)
		leucine-rich repeat	326..351	CDD:275381	7/24 (29%)
		LRR 7	334..359		7/24 (29%)
		leucine-rich repeat	352..377	CDD:275381	6/25 (24%)
		LRR 8	360..385		5/25 (20%)
		leucine-rich repeat	378..403	CDD:275381	8/24 (33%)
		LRR 9	386..411		5/19 (26%)
		leucine-rich repeat	404..429	CDD:275381	0/1 (0%)
		LRR 10	412..437
		leucine-rich repeat	430..453	CDD:275381
		LRR 11	438..463
		leucine-rich repeat	456..480	CDD:275381