DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and zeel-1

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_490966.2	Gene:	zeel-1 / 189770	WormBaseID:	WBGene00021463	Length:	917	Species:	Caenorhabditis elegans

Alignment Length:	374	Identity:	91/374 - (24%)
Similarity:	138/374 - (36%)	Gaps:	119/374 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 STTNITTRIVAADSFFVFRTPAMSAHINSGINYFERLSDEILLDIFKWLPKKTLLRMATVCRRFN 270
            |..|||...:|             .|||.|                ::.....|..|.|..|
Worm   224 SLANITAAQIA-------------RHINDG----------------RYTRTNILEGMDTKFR--- 256

  Fly   271 RCSRDETLWTRLDLGLRTIRPGALEQIVRRGVLVIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSM 335
                 :|:.::|.|    :.|.|.:.|          |:|:..|.:.:....||  .|:|.....
Worm   257 -----DTILSKLLL----LNPKAYQFI----------AKTTQVEKSLSIGKRVF--ELEYYARHK 300

  Fly   336 ASITRSSLLTLLSHCRQLKKISLENIE-LDDDICAEIAKNEALEAVNLTMASGLTSNSVRLMMES 399
            :.||   .||::.|    ||...|.|: ||...|                .:.||...|:.:...
Worm   301 SIIT---TLTIVLH----KKKYWEKIQKLDIREC----------------EAQLTPGWVKQIGIM 342

  Fly   400 LTSLSSLNISWTDLSADAVTALVTHISPNLIRLNIA--GCRRV--LFD-SH-----VATLQKRCP 454
            |:||::|.||...||.:..:.|.... |||::|:|:  |.|::  :|. .|     :..||..|.
Worm   343 LSSLTTLEISNKPLSKEDFSELCDSF-PNLVQLDISDTGIRKLDGIFKLKHLKVLWMRNLQFECS 406

  Fly   455 QLLELDLSDCNSLT---------PTVITAIMKFKMLEYLSVSRCYLIPATKFIELKSMPSLTYLD 510
            ..: |||.....||         .|.|..||:|        ..|.:|          :|:||:||
Worm   407 SDM-LDLFKLTGLTALDVSRDVYKTNIKTIMQF--------VECGII----------LPNLTFLD 452

  Fly   511 IFGM-LSDTAMEVLEKQLPKMGINKFIHSSVSR-PTVGTRRTSIWGLRT 557
            ..|. |::..:..|... ||:.....|.::|.. .|.|....|...|:|
Worm   453 ASGTDLNENLLNSLASH-PKLQQIVAIDTNVQYIKTTGHEILSFGNLQT 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	6/44 (14%)
		leucine-rich repeat	302..327	CDD:275381	5/24 (21%)
		AMN1	309..480	CDD:187754	52/190 (27%)
		leucine-rich repeat	328..352	CDD:275381	7/23 (30%)
		leucine-rich repeat	353..376	CDD:275381	7/23 (30%)
		leucine-rich repeat	377..402	CDD:275381	4/24 (17%)
		leucine-rich repeat	403..428	CDD:275381	7/24 (29%)
		leucine-rich repeat	429..455	CDD:275381	10/35 (29%)
		leucine-rich repeat	456..480	CDD:275381	10/32 (31%)
		leucine-rich repeat	481..500	CDD:275381	2/18 (11%)
		leucine-rich repeat	506..529	CDD:275381	7/23 (30%)
zeel-1	NP_490966.2	leucine-rich repeat	346..370	CDD:275380	7/24 (29%)
		leucine-rich repeat	371..392	CDD:275380	6/20 (30%)
		leucine-rich repeat	393..417	CDD:275380	6/24 (25%)
		leucine-rich repeat	418..447	CDD:275380	9/46 (20%)
		leucine-rich repeat	448..471	CDD:275380	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162739
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930