DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and K05C4.9

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001362175.1	Gene:	K05C4.9 / 187021	WormBaseID:	WBGene00010585	Length:	718	Species:	Caenorhabditis elegans

Alignment Length:	269	Identity:	56/269 - (20%)
Similarity:	113/269 - (42%)	Gaps:	52/269 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 LVIRLAQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLK----KISLENIEL 363
            |.::...|||.|..:....|.|     .||...:::..::.:.:.:..:.::    .::|.|::|
Worm     8 LAVQKVATSIAEGHYEDMNETF-----ILDSKASNLIYAAFIKIPTSKKAIRIPELVLNLTNVDL 67

  Fly   364 -DDDIC---AEIAKNE-ALEAVNL----------TMASGLTSNSVRLMMESLTS-----LSSLNI 408
             :..:|   .|:.:.: .||::.|          ...:|.| |.|.|:.:.|..     |..|||
Worm    68 RNTTLCHNTIEMLRTQRTLESLALGSLLLIKKDYLCETGRT-NIVALLKDILNEKSRKRLRHLNI 131

  Fly   409 SWTDLSADAVTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRC---PQLLELDLSDCNSLTPT 470
            ....|.....:..::.:.|:|..||::   .:||::.  .|.:.|   |.|..||:|..|..:
Worm   132 RGAGLIGCGWSDKLSELFPSLKTLNVS---NILFEND--ELLRLCVSFPSLCVLDISGTNIAS-- 189

  Fly   471 VITAIMKFKMLEYLSVSRCYLIPATKFIELKSMPSLTYLDIFGMLS-DTAMEVLEKQLPKMGINK 534
             :..:...|.|:.||:.......|...::|..:.:|..||:....: :|:..||          :
Worm   190 -LHGLSNLKNLQELSIRYLEFANANNLVDLFQLTNLKVLDMSKSKNLETSKNVL----------R 243

  Fly   535 FIHSSVSRP 543
            |:...::.|
Worm   244 FVECGMNLP 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689
		leucine-rich repeat	302..327	CDD:275381	7/23 (30%)
		AMN1	309..480	CDD:187754	41/197 (21%)
		leucine-rich repeat	328..352	CDD:275381	2/23 (9%)
		leucine-rich repeat	353..376	CDD:275381	5/31 (16%)
		leucine-rich repeat	377..402	CDD:275381	9/34 (26%)
		leucine-rich repeat	403..428	CDD:275381	5/24 (21%)
		leucine-rich repeat	429..455	CDD:275381	7/28 (25%)
		leucine-rich repeat	456..480	CDD:275381	5/23 (22%)
		leucine-rich repeat	481..500	CDD:275381	4/18 (22%)
		leucine-rich repeat	506..529	CDD:275381	6/23 (26%)
K05C4.9	NP_001362175.1	leucine-rich repeat	126..151	CDD:275381	5/24 (21%)
		leucine-rich repeat	152..176	CDD:275381	7/28 (25%)
		leucine-rich repeat	177..198	CDD:275378	5/23 (22%)
		leucine-rich repeat	199..223	CDD:275378	5/23 (22%)
		leucine-rich repeat	224..253	CDD:275378	8/39 (21%)
		leucine-rich repeat	254..278	CDD:275378
		leucine-rich repeat	279..290	CDD:275378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930