Protein Alignment Skp2 and H24K24.2

DIOPT Version :10

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001300124.1
• Gene: H24K24.2 / 186774
• WormBaseID: WBGene00019239
• Length: 473
• Species: Caenorhabditis elegans
• Alignment Length: 364
• Identity: 67/364 - (18%)
• Similarity: 126/364 - (34%)
• Gaps: 115/364 - (31%)

  Fly   248 LDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVR-----RGVLVIRL 307
            :|:|.:...|.|:...       ||.           .|.::..|.|:.:.|     .|..::|.
 Worm    65 VDLFNYHVSKELVEAI-------RCQ-----------NLESLSLGNLDWVKRGRRFMNGYDIVRF 111

  Fly   308 AQTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLENIELDDD----IC 368
            .::.:.|.:        |..|..|:::|.|.........:::.....|....|.:::||    :|
 Worm   112 LESFLNEES--------RNVLHSLEITMESPFAKEWPAKINNMLPALKCFAINGQVNDDEFSHLC 168

  Fly   369 AEIAKNEALEA--VNLTMASGL------------------TSNSVRLMMESLTSLSSLNISWTDL 413
            ...:....|:.  .|:...||:                  ||:.:.|.  |||.|:.|::| .|.
 Worm   169 IGFSNLRVLDISNTNIRNLSGMKMLVNLQILSMRNLDINQTSDLIELF--SLTKLTVLDVS-QDK 230

  Fly   414 SADAVTALVTHISPNLIRLNIAGCRRVLFD-------------SHVATLQKRCPQLLELDLSDCN 465
            .......:.|::.          ||::|.|             ....||....|.::.:....|
 Worm   231 QNSGTKIISTYLE----------CRKILLDLKFIDCSRTDINREFAKTLLSSHPSIVHVSAIGC- 284

  Fly   466 SLTPTVITAIMKFKMLEYLSVSRCYLIPATKFIELKSMPSL--TYLDIFGMLSDTA----MEVLE 524
                            :..:.|:|    .|:.....|:.||  :.:|...:.::.|    :|.|.
 Worm   285 ----------------DLKNFSKC----GTRIFYCTSIESLFRSLIDFTNLKNELATCRCLEELH 329

  Fly   525 KQLPKMGINKFIH-SSVSRPTVGT------RRTSIWGLR 556
            :||......:.:| ||:.:..:.|      |.|.|.||:
 Worm   330 RQLNASRSTENLHYSSLLKLVIQTMNMFTSRSTLINGLQ 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box_DmSKP2-like	239..281	CDD:438920	6/32 (19%)
		leucine-rich repeat	302..327	CDD:275381	3/24 (13%)
		AMN1	309..480	CDD:187754	34/207 (16%)
		leucine-rich repeat	328..352	CDD:275381	4/23 (17%)
		leucine-rich repeat	353..376	CDD:275381	5/26 (19%)
		leucine-rich repeat	377..402	CDD:275381	9/44 (20%)
		leucine-rich repeat	403..428	CDD:275381	5/24 (21%)
		leucine-rich repeat	429..455	CDD:275381	6/38 (16%)
		leucine-rich repeat	456..480	CDD:275381	1/23 (4%)
		leucine-rich repeat	481..500	CDD:275381	3/18 (17%)
		leucine-rich repeat	506..529	CDD:275381	7/28 (25%)
H24K24.2	NP_001300124.1	PPP1R42	<162..>227	CDD:455733	14/66 (21%)