DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and F53G2.1

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_494284.1	Gene:	F53G2.1 / 186184	WormBaseID:	WBGene00018766	Length:	714	Species:	Caenorhabditis elegans

Alignment Length:	235	Identity:	56/235 - (23%)
Similarity:	92/235 - (39%)	Gaps:	45/235 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 LKKISLENIELDDDICAEIAKNEALEAVNLTMASGLTS---------NSVRLMMESLTSLSSLNI 408
            |.:||.:|.. :..|..||.:...|:::.|.....:.|         |...|:...|...|..|:
Worm    60 LSEISFKNFP-NSTIYVEILQKSCLKSLCLGNLKNIASFFEDDQKSINICYLLSYYLNEDSRRNL 123

  Fly   409 SWTDLS-----ADAVTALVTHISPNLIRLNIAGCRRVLFDSHVATLQKRCPQLLELDLSDCN--- 465
            ...|||     :...|..:.|:.|:|..|:|.|  |.|:......:.:..|:|:.||:||.|
Worm   124 QTLDLSGKEEFSTGWTVKIGHMFPSLTTLSIRG--RTLYKKEFLVVCQNFPKLISLDISDTNVQL 186

  Fly   466 -----------SLTPTVITAIMKF--------KMLEYLSVSRCYLIPATKFIEL-----KSMPSL 506
                       .||...:|.:..|        ..||:|.:||..|....|.:..     ..:.:|
Worm   187 LFGISYLIHLRELTMQNLTFLSHFVWLDLFHLSGLEFLDISRDKLNKDMKTVRQYVDCGMGLSNL 251

  Fly   507 TYLDIFGM-LSDTAMEVLEKQLPKMGINKFIHSSVSRPTV 545
            .:||..|. :.|..::.|:...||:.......|.:.|.|:
Worm   252 RFLDCSGTDIDDQLVQCLQLSHPKLKQICVFDSVLQRSTI 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689
		leucine-rich repeat	302..327	CDD:275381
		AMN1	309..480	CDD:187754	38/162 (23%)
		leucine-rich repeat	328..352	CDD:275381
		leucine-rich repeat	353..376	CDD:275381	7/22 (32%)
		leucine-rich repeat	377..402	CDD:275381	6/33 (18%)
		leucine-rich repeat	403..428	CDD:275381	7/29 (24%)
		leucine-rich repeat	429..455	CDD:275381	6/25 (24%)
		leucine-rich repeat	456..480	CDD:275381	10/45 (22%)
		leucine-rich repeat	481..500	CDD:275381	7/18 (39%)
		leucine-rich repeat	506..529	CDD:275381	6/23 (26%)
F53G2.1	NP_494284.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162733
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930