DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and F44E5.2

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_496512.2	Gene:	F44E5.2 / 185735	WormBaseID:	WBGene00009689	Length:	489	Species:	Caenorhabditis elegans

Alignment Length:	244	Identity:	53/244 - (21%)
Similarity:	94/244 - (38%)	Gaps:	72/244 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 KKISLENIELDDDICAEIA----------KNEALEAVNLTMASGLTS------------------ 390
            |.::|: ||||.:.|.:|:          ||...|.:.|...:.:.|
Worm    38 KLVALD-IELDPNYCLQISRKLNITKAVCKNVTTEHIKLLSNNCILSLTIGNIDKVKQVYQDDKE 101

  Fly   391 ----NSVRLMMESLTSLSSLNISWTDLSADAVTA-----LVTHISPNLIRLNIAGCRRVLFDSHV 446
                |..||:.:.|...|..|:.:.|:..:.:.:     .:.|:.|:|..|.:  |:|...:...
Worm   102 NPIINIARLLEDVLGEESRQNLQYLDIQGNELFSYNWPKALGHMLPSLQTLIV--CQRSFINDEF 164

  Fly   447 ATLQKRCPQLLELDLSDCN-----------SLTPTV-----------ITAIMKFKMLEYLSVSR- 488
            :.|....|.|.:||:||.|           :|....           |..:.:.|.|..|::||
Worm   165 SQLCNSFPNLHKLDISDTNIGNLSGISNLKNLQKLCMMNLEFESYDDIKELFEVKSLRVLNISRD 229

  Fly   489 -----CYLIPATKFIELKS-MPSLTYLDIFGMLSD-TAMEVLEKQLPKM 530
                 ..||  .::|:||. :|.|.:||..|...| .::..::...|.:
Worm   230 RKDFKPSLI--MQYIQLKEVLPELRFLDCSGTNVDKESISTIQNSHPNL 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689
		leucine-rich repeat	302..327	CDD:275381
		AMN1	309..480	CDD:187754	36/184 (20%)
		leucine-rich repeat	328..352	CDD:275381
		leucine-rich repeat	353..376	CDD:275381	10/31 (32%)
		leucine-rich repeat	377..402	CDD:275381	7/46 (15%)
		leucine-rich repeat	403..428	CDD:275381	4/29 (14%)
		leucine-rich repeat	429..455	CDD:275381	5/25 (20%)
		leucine-rich repeat	456..480	CDD:275381	8/45 (18%)
		leucine-rich repeat	481..500	CDD:275381	7/24 (29%)
		leucine-rich repeat	506..529	CDD:275381	5/23 (22%)
F44E5.2	NP_496512.2	leucine-rich repeat	123..148	CDD:275380	2/24 (8%)
		leucine-rich repeat	149..173	CDD:275380	5/25 (20%)
		LRR_4	172..215	CDD:289563	9/42 (21%)
		leucine-rich repeat	174..195	CDD:275380	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930