DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Skp2 and C48D1.1

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001040928.2	Gene:	C48D1.1 / 178271	WormBaseID:	WBGene00008177	Length:	632	Species:	Caenorhabditis elegans

Alignment Length:	421	Identity:	92/421 - (21%)
Similarity:	158/421 - (37%)	Gaps:	107/421 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 LNFQPSTSRLAQVRQAKKPSTTNITT-RIVAADSFFVFR-------------TPAMSAHINSGIN 237
            :...|.|......||.|:.|...:.. ....:.|:.:||             ...::......:.
Worm    61 VTLHPQTLDENTARQLKQFSLKELKIGNFSKSKSWCIFRRKETRHVDIVRILEAVLNEETRKNLQ 125

  Fly   238 YFERLSDEILLDIFKW-------LPKKTLLRMATV-------CRRFNRCSRDETLWTRLDL-GLR 287
            |.....|:.|:.  :|       ||..|.|.|:.|       .:.|...|...:    ||: |..
Worm   126 YLHIEKDQKLMK--RWTAKIGNMLPSLTHLTMSDVHINEDDFYQLFGNFSNLRS----LDISGTN 184

  Fly   288 TIRPGALEQIVRRGVLVIRLAQTSIQEPAFAPYTE---VFRTR-LQYLDLSMASI---TRSSLLT 345
            .:....:.::.:..||.:|       :.:.|.|||   :|..: |:.||:|....   :|::::.
Worm   185 ILNIAGISRLKQLEVLALR-------DFSIATYTELKDLFNLKHLRVLDVSQTRFNLHSRNNIVE 242

  Fly   346 LLSHCR----QLKKISLENIELDDDICAEIAKNEA-LEAVNLTMASGLTS--NSVRLMMESLTSL 403
            ..:.|:    :|:.:......|..||...:.|.:. |:.|...|....||  |.||:
Worm   243 QFTECKMELPELRFMDCTRTSLSGDILECLLKTQRNLQLVTTIMTEAETSQYNDVRV-------- 299

  Fly   404 SSLNISWTDLSADAVTALVT--------------HIS---PNLIRLNIAGCRRVL------FDSH 445
              ||.::...|..|:...:|              .||   .||..|||..|.:.:      |||
Worm   300 --LNTAYFHKSVQALVYCLTARKEFDSGYCMKAIRISISEDNLQNLNIPSCIKTIVKSMQTFDS- 361

  Fly   446 VATLQK--RCPQLLELDLSD--CNSLTPTVITAIMKFKML-------EYLSVSRCYLIPATKFIE 499
            ::..|.  :|..:..:..|:  |::....::.|:|.|..|       .|:.|:..|.....|.:.
Worm   362 ISVTQNGLKCLIIFGMLYSNQLCSNGVTLLVEALMSFVYLYKRMISEAYVKVNISYWNAVEKLVN 426

  Fly   500 LKSMPSLTYLDIFGMLSDTAME-VLEKQLPK 529
            ||    |..|| |..:|.|||. :||.::.|
Worm   427 LK----LGKLD-FDKISKTAMSFLLENRVSK 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	12/58 (21%)
		leucine-rich repeat	302..327	CDD:275381	8/27 (30%)
		AMN1	309..480	CDD:187754	47/211 (22%)
		leucine-rich repeat	328..352	CDD:275381	6/30 (20%)
		leucine-rich repeat	353..376	CDD:275381	5/22 (23%)
		leucine-rich repeat	377..402	CDD:275381	8/26 (31%)
		leucine-rich repeat	403..428	CDD:275381	7/41 (17%)
		leucine-rich repeat	429..455	CDD:275381	10/33 (30%)
		leucine-rich repeat	456..480	CDD:275381	5/25 (20%)
		leucine-rich repeat	481..500	CDD:275381	5/25 (20%)
		leucine-rich repeat	506..529	CDD:275381	10/23 (43%)
C48D1.1	NP_001040928.2	leucine-rich repeat	124..149	CDD:275380	5/26 (19%)
		leucine-rich repeat	150..174	CDD:275380	5/23 (22%)
		leucine-rich repeat	175..196	CDD:275380	3/24 (13%)
		leucine-rich repeat	197..221	CDD:275380	8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162738
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930