Protein Alignment Skp2 and skpt-1

DIOPT Version :9

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_741137.1
• Gene: skpt-1 / 175749
• WormBaseID: WBGene00018613
• Length: 421
• Species: Caenorhabditis elegans
• Alignment Length: 394
• Identity: 111/394 - (28%)
• Similarity: 185/394 - (46%)
• Gaps: 20/394 - (5%)

  Fly   182 DGTASL----NFQPSTS-RLAQVRQAKKPSTTNITTRIVAADSFFVFRTPAMSAHINSGINYFER 241
            |.|.|:    |..|..| ||:....::|..:.|:..:.:..|..    .|.......|..|.|::
 Worm    30 DETISIFPCYNLYPKKSLRLSVSGNSEKLKSINLNCKNLVEDEI----APIKRKDARSIQNPFKK 90

  Fly   242 LS--DEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGVLV 304
            .|  |||...||..|.||.||....||.||.........|...|...|.|...:|..:.:|.:.|
 Worm    91 YSIPDEITEQIFSNLKKKDLLSAMLVCHRFYGIGHKSRNWIITDAQDRPISEISLIALSQRKIKV 155

  Fly   305 IRLAQTSIQ-----EPAFAPYTEVFRTRLQYLDLSMASITRSSLLTLLSHCRQLKKISLENIELD 364
            :|||.....     :........:..:||:.||||..::|...:..:|..|::||.:|:|..:||
 Worm   156 LRLAGAKADRILRADERLVEVALLSTSRLELLDLSRTNLTARQMQIMLKPCQKLKCLSIEGNQLD 220

  Fly   365 DDICAEIAKNEALEAVNLTMASGLTSNSVRLMMESLTSLSSLNISWTDLSADAVTALVTHISPNL 429
            |.:...||:|..|..::::|.:|:|:|...|:..:...|..||::|..|:...||.::..|...|
 Worm   221 DHVAICIAENRGLRELDISMTNGITANGASLIFRNCKDLQQLNLAWCGLTQPIVTVIIHSIGEKL 285

  Fly   430 IRLNIAGCRR--VLFDSHVATLQKRCPQLLELDLSDCNSLT-PTVITAIMKFKMLEYLSVSRCYL 491
            .:||::|..|  .:.:.|:..|..:...:.:|||||...:: |.:...:.||..|..:|::|||.
 Worm   286 KKLNLSGTVRNFGINNKHIEILAAKSNYVTDLDLSDNVEISDPGLAVILNKFPRLTTISLNRCYG 350

  Fly   492 IPATKFIELKSMPSLTYLDIFGMLSDTAMEVLEKQLPKMGINKFIHSSVSRP-TVGTRRTSIWGL 555
            :.....:...|.|||.||::.|.:|||.||:..:....:.:|:...:..::| :.......|||.
 Worm   351 LDPNMVVHFNSKPSLVYLNVHGCVSDTNMELFLEMCSNLKVNRQYFNFTAKPVSYQCESNMIWGQ 415

  Fly   556 RTRD 559
            ...|
 Worm   416 TMMD 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	17/46 (37%)
		leucine-rich repeat	302..327	CDD:275381	4/29 (14%)
		AMN1	309..480	CDD:187754	48/178 (27%)
		leucine-rich repeat	328..352	CDD:275381	8/23 (35%)
		leucine-rich repeat	353..376	CDD:275381	10/22 (45%)
		leucine-rich repeat	377..402	CDD:275381	6/24 (25%)
		leucine-rich repeat	403..428	CDD:275381	8/24 (33%)
		leucine-rich repeat	429..455	CDD:275381	7/27 (26%)
		leucine-rich repeat	456..480	CDD:275381	8/24 (33%)
		leucine-rich repeat	481..500	CDD:275381	5/18 (28%)
		leucine-rich repeat	506..529	CDD:275381	9/22 (41%)
skpt-1	NP_741137.1	F-box-like	92..130	CDD:372399	15/37 (41%)
		AMN1	150..373	CDD:187754	64/222 (29%)
		leucine-rich repeat	153..183	CDD:275381	4/29 (14%)
		leucine-rich repeat	184..208	CDD:275381	8/23 (35%)
		leucine-rich repeat	209..232	CDD:275381	10/22 (45%)
		leucine-rich repeat	233..258	CDD:275381	6/24 (25%)
		leucine-rich repeat	259..284	CDD:275381	8/24 (33%)
		leucine-rich repeat	285..313	CDD:275381	7/27 (26%)
		leucine-rich repeat	314..339	CDD:275381	8/24 (33%)
		leucine-rich repeat	340..362	CDD:275381	5/21 (24%)
		leucine-rich repeat	365..388	CDD:275381	9/22 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55942
Inparanoid	1	1.050	151	1.000	Inparanoid score	I2959
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005610
OrthoInspector	1	1.000	-	-		oto17822
orthoMCL	1	0.900	-	-		OOG6_109192
Panther	1	1.100	-	-	O	PTHR16134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5156
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.920