Protein Alignment Skp2 and fbxl-2

DIOPT Version :10

• Sequence 1: NP_730815.2
• Gene: Skp2 / 40548
• FlyBaseID: FBgn0037236
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_497980.2
• Gene: fbxl-2 / 175630
• WormBaseID: WBGene00007168
• Length: 622
• Species: Caenorhabditis elegans
• Alignment Length: 384
• Identity: 77/384 - (20%)
• Similarity: 137/384 - (35%)
• Gaps: 122/384 - (31%)

  Fly   241 RLSDEILLDIFKWLP-KKTLLRMATVCRRFNRCSRDETLWTRLDLGLRTIRPGALEQIVRRGVLV 304
            :|.|.||..|.:.:| |..||::..||.|                         |...|:|.|..
 Worm    38 QLKDSILDIIVEHVPLKDRLLKLRPVCHR-------------------------LSDSVKRSVKS 77

  Fly   305 IRLAQTSI---QEPAFAPYTEVFRTRLQYL--DL----SMASIT----RSSLLTLLSHCRQLKKI 356
            :...:..:   .:...:.:..|:...:|::  ||    |:...|    |.|:::.::.|.|||::
 Worm    78 VEFLRDELDYCDDAKISFFLAVYGKNVQHMNYDLFRSCSLREYTQWSWRQSVISSVTRCPQLKQL 142

  Fly   357 -----------------------SLENIELD----DDICAEIAKNEALEAVNLTMASGLTSNSVR 394
                                   .||.:.:|    :..|...|. :.|..:.|.....|......
 Worm   143 DILICCRHRLRDGDLQVIFKQCNQLEELRMDASYINGHCFSKAP-QTLRKLELECCQTLNKQGFI 206

  Fly   395 LMMESLTSLSSLNISWT------------DLSADAVTALVTHISPNLIRLNIAGCRRVLFDSHVA 447
            .|...|..|.:|::|..            |:.:....::|......:.:..:|..||:   |.:.
 Worm   207 GMCSRLFKLQTLHVSLMQCIDEQLIKRIGDMKSLKNLSVVADPDQKMNQFRLAEIRRL---SKLT 268

  Fly   448 TL---------QKRCPQLLELDLSDCNSLTPTVITAIMKFKMLEYLSVSRCYLIPATKFIELKSM 503
            ||         .|....|.:|..|...|             .:|:||:|.|..|.:....:||::
 Worm   269 TLCLDGVNNVTDKFLGDLSDLSTSPAGS-------------SIEHLSLSFCKNIGSNGISKLKTL 320

  Fly   504 PSLTYLDIFGMLS---DTAMEV------LEKQL--------PKMGINKFIHSSVSRPTV 545
            |:|..|::.|:..   .|.:|.      ||:.|        ||. |.:|:::..|..|:
 Worm   321 PNLKSLNLDGVSKRDISTGLEAIGQAGRLERLLVSEDTYVNPKT-IAEFVNTCESLRTL 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box_DmSKP2-like	239..281	CDD:438920	12/40 (30%)
		leucine-rich repeat	302..327	CDD:275381	2/27 (7%)
		AMN1	309..480	CDD:187754	38/231 (16%)
		leucine-rich repeat	328..352	CDD:275381	8/33 (24%)
		leucine-rich repeat	353..376	CDD:275381	7/49 (14%)
		leucine-rich repeat	377..402	CDD:275381	5/24 (21%)
		leucine-rich repeat	403..428	CDD:275381	5/36 (14%)
		leucine-rich repeat	429..455	CDD:275381	7/34 (21%)
		leucine-rich repeat	456..480	CDD:275381	4/23 (17%)
		leucine-rich repeat	481..500	CDD:275381	6/18 (33%)
		leucine-rich repeat	506..529	CDD:275381	8/39 (21%)
fbxl-2	NP_497980.2	leucine-rich repeat	104..138	CDD:275381	8/33 (24%)
		leucine-rich repeat	139..166	CDD:275381	2/26 (8%)
		LRR	163..>388	CDD:443914	49/234 (21%)
		leucine-rich repeat	189..214	CDD:275381	5/24 (21%)
		leucine-rich repeat	215..266	CDD:275381	8/53 (15%)
		leucine-rich repeat	267..297	CDD:275381	7/42 (17%)
		leucine-rich repeat	298..322	CDD:275381	8/23 (35%)
		leucine-rich repeat	349..374	CDD:275381	7/25 (28%)