DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and CG44004

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001262004.2	Gene:	CG44004 / 14462879	FlyBaseID:	FBgn0264746	Length:	368	Species:	Drosophila melanogaster

Alignment Length:	236	Identity:	55/236 - (23%)
Similarity:	97/236 - (41%)	Gaps:	63/236 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 FRTRLQYLDLSMASITRS----SLLTLLSHCRQLKKISLENIELDDDICAEIAKNEALEAVNLTM 384
            |..::..|.||::...||    .:|.::....|||::|::.. :|::: .||.|..|||.:|:..
  Fly   120 FLRKINKLLLSLSLEQRSRFPFEILKVVGEMTQLKELSVKGY-IDENV-NEIQKLVALEKLNIEQ 182

  Fly   385 ASGLTSNSVRLM--MESLTSLSSLNIS--------------WTDLSADAVTALVTHISPNLIRLN 433
            ...|....|.::  ..||::|..|.|:              |.||  :.:..::..::|.|
  Fly   183 HYYLDKPDVNILRICSSLSNLRKLTINNVHIISCEEPHSKMWADL--ETLKLIICALTPEL---- 241

  Fly   434 IAGCRRVLFDSHVATLQKRCPQLLELDLSDC-NSLTPTVITAIMK----FKMLEYLSVSRCY-LI 492
                             ..||.|..||:... ||....::..|:|    .|.|    ..||: .|
  Fly   242 -----------------PDCPNLKVLDIHYLRNSNEGYILKFILKNGRNLKTL----YERCHPPI 285

  Fly   493 PATKFIE-LKSMPSLTYL-------DIFGMLSDTAMEVLEK 525
            .|..|:: |:..|:|.||       .::.....|.:|:|.:
  Fly   286 DANGFLQLLRGCPNLRYLYTPLEYIKLYAAYLSTIVEILRE 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689
		leucine-rich repeat	302..327	CDD:275381	1/2 (50%)
		AMN1	309..480	CDD:187754	40/180 (22%)
		leucine-rich repeat	328..352	CDD:275381	6/27 (22%)
		leucine-rich repeat	353..376	CDD:275381	7/22 (32%)
		leucine-rich repeat	377..402	CDD:275381	7/26 (27%)
		leucine-rich repeat	403..428	CDD:275381	6/38 (16%)
		leucine-rich repeat	429..455	CDD:275381	2/25 (8%)
		leucine-rich repeat	456..480	CDD:275381	7/28 (25%)
		leucine-rich repeat	481..500	CDD:275381	6/20 (30%)
		leucine-rich repeat	506..529	CDD:275381	6/27 (22%)
CG44004	NP_001262004.2	leucine-rich repeat	75..101	CDD:275381
		leucine-rich repeat	121..152	CDD:275381	6/30 (20%)
		leucine-rich repeat	153..172	CDD:275381	6/20 (30%)
		leucine-rich repeat	175..202	CDD:275381	7/26 (27%)
		leucine-rich repeat	203..226	CDD:275381	4/22 (18%)
		leucine-rich repeat	247..273	CDD:275381	7/25 (28%)
		leucine-rich repeat	274..299	CDD:275381	8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR16134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100