DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Skp2 and LOC110437745

DIOPT Version :9

Sequence 1:	NP_730815.2	Gene:	Skp2 / 40548	FlyBaseID:	FBgn0037236	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_021323868.1	Gene:	LOC110437745 / 110437745	-ID:	-	Length:	579	Species:	Danio rerio

Alignment Length:	236	Identity:	50/236 - (21%)
Similarity:	85/236 - (36%)	Gaps:	65/236 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SVVG---ALVSTTKSSHYEHPSSPSALTFEALEEMGIGMLDSEESSSSALSAIALAVSATSDDNS 91
            :|:|   .:||..:|...:.....:.|..:|:.:..||.|.|.:::|..:          .|:..
Zfish   269 AVIGRGQRMVSQQESKLAQLQEHRARLEAQAISDDHIGFLQSFQAASGPM----------QDEAG 323

  Fly    92 NETTPCASVSRMAHQLQHTQRLSLG----STGDITLDSPAVEDSLSMSRQSAEKLQILAQAKRSS 152
            .|.         ..:.:.|.|.|||    :.|:|   ...:||..|...|....:..||::: |.
Zfish   324 QEA---------EQEAELTLRFSLGDVKAALGEI---RDRLEDIRSGEVQYRHSVSTLAESE-SM 375

  Fly   153 LGSEGSGNSNSPSKRLRNPLAAVTCNNQIDG---TASLNFQPSTS---------RLAQVRQAKKP 205
            :........:...|.||.   ..|.:.::.|   ..|||  |.|:         |....|..|..
Zfish   376 MSVRSMRRKDWSLKDLRR---IKTGHKKVKGYLEDVSLN--PVTAYPFLILSEDRKQLKRGEKLQ 435

  Fly   206 STTNITTR------IVAADSFFVFRTPAMSAHINSGINYFE 240
            ...|.|.|      ::|.:||            .:|.:|:|
Zfish   436 FYRNNTQRYDVWSCVLAKESF------------QTGRHYWE 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Skp2	NP_730815.2	F-box-like	239..284	CDD:289689	1/2 (50%)
		leucine-rich repeat	302..327	CDD:275381
		AMN1	309..480	CDD:187754
		leucine-rich repeat	328..352	CDD:275381
		leucine-rich repeat	353..376	CDD:275381
		leucine-rich repeat	377..402	CDD:275381
		leucine-rich repeat	403..428	CDD:275381
		leucine-rich repeat	429..455	CDD:275381
		leucine-rich repeat	456..480	CDD:275381
		leucine-rich repeat	481..500	CDD:275381
		leucine-rich repeat	506..529	CDD:275381
LOC110437745	XP_021323868.1	RAD18	8..>99	CDD:333230
		RING_Ubox	10..53	CDD:327409
		zf-B_box	152..191	CDD:306989
		SMC_N	<213..>393	CDD:330553	30/146 (21%)
		SPRY_PRY_C-I_1	407..575	CDD:293968	17/72 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930