DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9776 and Zfp318

DIOPT Version :9

Sequence 1:	NP_649455.1	Gene:	CG9776 / 40546	FlyBaseID:	FBgn0027866	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	NP_997554.2	Gene:	Zfp318 / 57908	MGIID:	1889348	Length:	2237	Species:	Mus musculus

Alignment Length:	1440	Identity:	287/1440 - (19%)
Similarity:	453/1440 - (31%)	Gaps:	534/1440 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DEDSATIQLGDRRLGNAVDHDLLPGPPGVDEKSGNENCEPRSS-------------GSGKRGKSN 53
            |.:||    |.|:..|:     ||..|.|..:|..|: .|..:             |..:.||..
Mouse   587 DPESA----GTRQKANS-----LPSTPAVKLESLEES-NPEYAKIHNLLKTIGLDIGVAEIGKLA 641

  Fly    54 SRRRSTSRGRSDSRNTSPSNTRRRHSLSRSLTPPRRRYDSPDYGRYSRRRFDRDRRRSPER---- 114
            :|.:....|:..|...|..   ||.|..|.|:              ..|.|..||..|.|.
Mouse   642 ARTQERLHGKKPSSRPSAD---RRLSADRHLS--------------GDRHFSADRCSSVEHSFTA 689

  Fly   115 --RRSPPRRGRRYGRSRSRSMSPRRGGRWSPKKKPSSPPVP-------PPH-GGPHPQMTPGYGA 169
              |.|.|.|........|.:.||.     .....|:||..|       ||. ...||
Mouse   690 DWRSSDPHRPESRETHHSNTQSPE-----VSHPHPASPVDPYLRTKNSPPFLKSDHP-------- 741

  Fly   170 MAAHIYGSYVAPPDVY--GHQYGIPPNSFPPQGPG-------------YGIPGAPPDQSSFGSGY 219
             ..|:.|     |:|.  |.|..:......|..|.             :.||||    |.|.:..
Mouse   742 -VCHVSG-----PEVVGSGFQSSVAVRCMLPSAPSTPIRLPHSAALSQFHIPGA----SQFAAAR 796

  Fly   220 GPP-------PTSAWDV----NVYGQQVWINQPISGVQPSA---SD------------------- 251
            .||       |::::|.    ..|....|...|.|  ||.:   ||
Mouse   797 IPPNYQGSVIPSASFDAYRHYMAYAASRWPMYPAS--QPPSHPLSDPHRLLPVTKQAARSRPNLR 859

  Fly   252 --SLIQPQKARE------TLSGKTIGEEQSVPAL----------EGAGLTPQDAVAQEAEKQKDE 298
              ..:.|.|.::      ::|.|.|....|:|:|          |....:.:..|.:|.||.|.|
Mouse   860 VIPTVTPAKPKQEIPVLGSISVKRIPVRVSIPSLIKYNPKKISDEKNRASQKQKVIEEREKLKTE 924

  Fly   299 LKKQRANYVKKVSLLKKEMKVLKDQ-----REDLAAGDAPPSPTTKNFIEENDRLQMQIKKKLDT 358
            .:.::    ||:..|..|::.|..|     |:.....|....|    .:.|..|||..|.|.:..
Mouse   925 QEARQ----KKMFYLTTELERLHKQQGEMLRKKRREKDGHKDP----LLMEVSRLQDSIMKDIAE 981

  Fly   359 I----------ENVIDMLNGIIGYEEVED--EPSNQKSHGKTQPEQQDSRSHSSSESSADSSESS 411
            :          ::.:|.:..|:|.:..:.  :.||.......:||::.|:| ...|.|..:|.||
Mouse   982 LHKETEEAEKKQSELDKVAQILGIDIFDKSLKSSNDSKESTEKPEKEKSKS-PEKELSPSNSSSS 1045

  Fly   412 SSSSTASDSSSDNEDGEGAGGAVGSPTNRLKHRAIKSMKSKQLHGEMKAVPTQAQNYNFVFFDPE 476
            :..|..::.|           .:.||:         |.:|.|...:....|..|..|    :|..
Mouse  1046 NKESKMNEKS-----------CIKSPS---------STESLQPTVKQSDQPVAAYEY----YDAG 1086

  Fly   477 QHWCESCGVFPKSARDYLKHLHAEEHMNRETIE---TPWHVGIDHD-PFPTFENAPARRVPVRGM 537
            .|||:.|.....:..|:..|:|.::|  .:|::   .||......: ...|.:......||.:|.
Mouse  1087 SHWCKDCNTTCGTMFDFFTHMHNKKH--TQTLDPYNRPWASKTQSEAKQDTVKRTDKITVPAKGS 1149

  Fly   538 QFLVPANAWFCKLCSVWIGDLHCASAHLKSRLHSNKYQQFLNQNPNYEIEWQTNRERAM-----N 597
            :||:|...::|:||..::||......|:|...|:..|::::.:||.||.....:|:..:     .
Mouse  1150 EFLIPVTGFYCQLCEEFLGDPISGEQHVKGHQHNENYKKYVEENPLYEERRNLDRQAGLAVVLET 1214

  Fly   598 QQKDHDDAKNKKSKK-DEDKASKK----RKKKGGDKKKKKRKHGKKSKRSTIDANSTSSSSDSSS 657
            :::..::.|.|.::| .|:|..||    |:.|..||                      :..:...
Mouse  1215 ERRRQNELKRKLNEKPKEEKIEKKARIVREVKEDDK----------------------APGELEE 1257

  Fly   658 SEEENGQQPKKGRTEQQPICQSDKSTNAASIRVAMRKQESTPTNLKPEVPCQPVVPPPPPIIKDS 722
            ...|:|..|:||..:           ..||:|          ..:|.||..:|.|         :
Mouse  1258 QLSEDGSAPEKGEVK-----------GNASLR----------PQVKEEVKKEPSV---------A 1292

  Fly   723 TIPSERGKWTAASVEDQSKDQKNRDDTMLKQWNNVQPVISESEKKLLEQLKGRLKNKGARDQNNH 787
            :|.:..||::                     |       .:.||   |:.||.:...||
Mouse  1293 SIAASFGKFS---------------------W-------KKPEK---EEEKGSVVTPGA------ 1320

  Fly   788 KAVPTEANDEKFRRGGGRHSRSRSKRRSYSRSISRGRDRDRRDRERDRDRGRRRRSRSRGRHFSR 852
               |.|                                 |..:..:|||.|:....:::
Mouse  1321 ---PKE---------------------------------DTVETSKDRDDGKAEVGKAK------ 1343

  Fly   853 SPIRSSRRSRSRQGRSRRSRSRSIERVERPVVKHSEFRPRTVPERKQTDIKRD--------KKDA 909
             ||:                   |:...:.|:.|:......|....||.|:.:        :|..
Mouse  1344 -PIK-------------------IKLSGKTVIAHTSPWTPVVTTSTQTKIRPNLPIPSTVLRKSG 1388

  Fly   910 ESKSKSSKPSNNSL----PGGKKLPFIGKMPVFKKQS--------VPSFNYDASAVYTNGCLE-- 960
            .:......|.|..|    .|....|    :||.|:.|        :.|..:....|...|..|
Mouse  1389 SATVSKPAPLNTFLSIKSSGTSTKP----LPVVKESSSDLLLPPDIISKAFGGEEVVLKGSPEEK 1449

  Fly   961 -------------------APPPPPPPLGGATSQIAVRQQAPTAAQIQMAMMEDAFGNAPPFHPD 1006
                               .|||||||                               .||
Mouse  1450 VELAEKNEPSQVPEQMLALLPPPPPPP-------------------------------PPP---- 1479

  Fly  1007 AGMMVDYDELMPDPVQFANLMTSCPPPPPPGEGSEGDAHGPED--------------------GD 1051
                       |.|          ||||||....:..|..|..                    |.
Mouse  1480 -----------PPP----------PPPPPPQAVPQLSAPSPAQANVVLTPVKSNSVISQTFSLGF 1523

  Fly  1052 QHDNENREDVLPPGIDEAESALVPHPLDAAAQSRDGELPKDLVEALDIIFPSDVAILEASNGNSE 1116
            |..|     :|.||:..|..|              .|.|        .:.|||    |.:.|.||
Mouse  1524 QGPN-----ILNPGLPVAFMA--------------SEQP--------TVIPSD----ETAPGVSE 1557

  Fly  1117 KQEDVT-ITTIVEDDAVLSVI---HLQDLAKEGIHLVTINEAEV--------PKKSHIQTSEKIE 1169
            ...|.| |:.:|.....||.:   ..:.|.|....|.|.|..::        .|.:|   ..|:.
Mouse  1558 SDWDQTLISMLVRPPPPLSSVFSEQAKKLEKRNSCLATANAKDLYDIFYSSGGKGAH---ETKLS 1619

  Fly  1170 KLQDLNGKSDDGVNIKLIDAEDIPMPNSPPAEPSFDEETKSKALQKQADISEIPEPAVSPSDSEK 1234
            .....||:|.   ::...::.|.....:..:..|.::..:..||....:||.:..|.  ....|.
Mouse  1620 SSTLANGESS---SLPRTESSDFSSTCTLNSSMSSEDLPQCSALVTATEISNLENPI--SKGMES 1679

  Fly  1235 LRRQSELDEL 1244
            ..:.|.:|::
Mouse  1680 TGKWSVVDQI 1689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9776	NP_649455.1	bZIP	<289..322	CDD:304365	10/32 (31%)
CG9776	NP_649455.1	ZnF_U1	546..577	CDD:197732	9/30 (30%)
Zfp318	NP_997554.2	Interaction with AR. /evidence=ECO:0000269\|PubMed:16446156	1..1114		135/613 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..221
		Herpes_ICP4_C	<18..>142	CDD:332854
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..350
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..612		11/33 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..732		25/108 (23%)
		Neuromodulin_N	<899..1031	CDD:331332	29/139 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	945..966		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1012..1072		18/80 (23%)
		ZnF_U1	1085..1119	CDD:197732	9/35 (26%)
		ZnF_U1	1155..1189	CDD:197732	9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1289		14/86 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1302..1342		15/112 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1366..1395		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1449..1497		17/103 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1614..1651		6/42 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1727..1770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1790..1867
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2064
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2178..2237
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837744
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28V80
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007912
OrthoInspector	1	1.000	-	-		oto94557
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15577
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7137
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920