DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9776 and ZNF318

DIOPT Version :10

Sequence 1:NP_649455.1 Gene:CG9776 / 40546 FlyBaseID:FBgn0027866 Length:1260 Species:Drosophila melanogaster
Sequence 2:NP_055160.2 Gene:ZNF318 / 24149 HGNCID:13578 Length:2279 Species:Homo sapiens


Alignment Length:1495 Identity:298/1495 - (19%)
Similarity:468/1495 - (31%) Gaps:584/1495 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 HDLLPGPPGVDEKSGNENCEPRSSGSGKRGKSNSRRRSTSRGRSDSRNTSPSNTRRRHSLSRSLT 85
            ||||. ..|:|            .|..:..:..:|.:....|:..|..:|..   ||.|:.    
Human   593 HDLLK-TIGLD------------IGVAEISQLAARTQERLHGKKPSLRSSAD---RRSSVD---- 637

  Fly    86 PPRRRYDSPDYGRYSRRRFDRDRRR------SPERRRSPPRRGRRYGRSRSRSMSPRRGGRWSPK 144
                ||.|.|:......||..||..      |.:||.|.|.        |..|.........||:
Human   638 ----RYFSADHCSSVDHRFSADRCSSVDHCFSADRRSSDPH--------RLESREAHHSNTHSPE 690

  Fly   145 KKPSSPPVP----------PPH-GGPHPQMTPGYGAMAAHIYGSYVAPPDVY--GHQYGIPPNSF 196
            .....||.|          ||. ...||         ..||.|     |:|.  |.|..:.....
Human   691 VSHPHPPSPVDPYLLTKNSPPFLKSDHP---------VGHISG-----PEVVGSGFQSSVAVRCM 741

  Fly   197 PPQGPGYGIPGAP--------------PDQSSFGSGYGPP-------PTSAWDV----NVYGQQV 236
            .|..     |.||              |..|.|.:...||       |.:::|.    ..|....
Human   742 LPSA-----PSAPIRLPHTAALSQFHMPRASQFAAARIPPNYQGPAIPPASFDAYRHYMAYAASR 801

  Fly   237 WINQPISGVQPS------------------------------ASDSLIQPQKARETLSGKTIGEE 271
            |...|.|  |||                              ..|...|.:..|.::....:..:
Human   802 WPMYPTS--QPSNHPVPEPHRIMPITKQATRSRPNLRVIPTVTPDKPKQKESLRGSIPAAQVPVQ 864

  Fly   272 QSVPALEGAGLTPQ---DAVAQEAEKQK-----DELKKQRANYVKKVSLLKKEMKVLKDQ----- 323
            .|:|:|  ....|:   |...:.::|||     ::||..|....||:..|:.|::.|..|     
Human   865 VSIPSL--IRYNPEKISDEKNRASQKQKVIEEREKLKNDREARQKKMYYLRTELERLHKQQGEML 927

  Fly   324 REDLAAGDAPPSPTTKNFIEENDRLQMQIKKKLDTI----------ENVIDMLNGIIGYEEVEDE 378
            |:.....|....|    .:.|..|||..|.|.:..:          ::.:|.:..|:|....:  
Human   928 RKKRREKDGHKDP----LLVEVSRLQDNIMKDIAELRQEAEEAEKKQSELDKVAQILGINIFD-- 986

  Fly   379 PSNQKSHGKTQPEQQDSRSHSSSESSADSSESSSSSSTASDSSSDNEDGEGAGGAVGSPTNRLKH 443
                    |:|....|||..:.....|:.|:|....|:.|:|||:.|          |..|..|.
Human   987 --------KSQKSLSDSREPTEKPGKAEKSKSPEKVSSFSNSSSNKE----------SKVNNEKF 1033

  Fly   444 R--AIKSMKSKQLHGEMKAVPTQAQNYNFVFFDPEQHWCESCGVFPKSARDYLKHLHAEEHMNRE 506
            |  :.|..:|.|...:....||.|..|    :|...|||:.|.....:..|:..|:|.::|  .:
Human  1034 RTKSPKPAESPQSATKQLDQPTAAYEY----YDAGNHWCKDCNTICGTMFDFFTHMHNKKH--TQ 1092

  Fly   507 TIETPWHVGIDHDPFPTFENAPARR----------VPVRGMQFLVPANAWFCKLCSVWIGDLHCA 561
            |:: |:     :.|:.:...:.|::          ||.:|.:||||.:.::|:||..::||....
Human  1093 TLD-PY-----NRPWASKTQSEAKQDAIKRTDKITVPAKGSEFLVPISGFYCQLCEEFLGDPISG 1151

  Fly   562 SAHLKSRLHSNKYQQFLNQNPNYE------------IEWQTNRERAMN-----QQKDHDDAKNKK 609
            ..|:|...|:.||::::::||.||            :..:|.|.|...     .:|..::.|.||
Human  1152 EQHVKGHQHNEKYKKYVDENPLYEERRNLDRQAGLAVVLETERRRQSELKRKLSEKPKEEKKEKK 1216

  Fly   610 SK-----KDEDKASKKRK------KKGGDKKKKKRKHG-KKSKRSTIDANSTSSSS--------- 653
            :|     |::||.|:|.:      :...:|.:.||..| |...:..:...|.:|||         
Human  1217 AKAVKEVKEDDKVSEKLEDQLSEGRNSPEKAENKRNTGIKLQLKEEVKKESPTSSSFGKFSWKKP 1281

  Fly   654 -----------DSSSSEE--ENGQQPKKGRTEQQPICQSDKSTNAASIRVAMRKQ---------- 695
                       .|.|.||  |:.:..:.|:||         :..|..|::.:..:          
Human  1282 EKEEEKSSLVTPSISKEEILESSKDKEDGKTE---------AGKAKPIKIKLSGKTVVAHTSPWM 1337

  Fly   696 ----ESTPTNLKPEVP---------CQPVVPPPPPIIKDSTIPSERGKWTAASVEDQSKDQKNRD 747
                .||.|.::|.:|         |...:..|.|:   :|..|.:...|.|             
Human  1338 PVVTTSTQTKIRPNLPIPSTVLRKSCSATMSKPAPL---NTFLSIKSSGTTA------------- 1386

  Fly   748 DTMLKQWNNVQPVISESEKKLLEQLKGRLKNKGARDQNNHKAVPTEANDEKFRRGGGRHSRSRSK 812
                    ...||:.||...||                    :|.:...:.|   ||        
Human  1387 --------KPLPVVKESSADLL--------------------LPPDIISKAF---GG-------- 1412

  Fly   813 RRSYSRSISRGRDRDRRDRERDRDRGRRRRSRSRGRHFSRSPIRSSRRSRSRQGRSRRSRSRSIE 877
                                                                             
Human  1413 ----------------------------------------------------------------- 1412

  Fly   878 RVERPVVKHSEFRPRTVPERKQTDIKRDKKDAESKSKSSKPSNNSLPGGKKLPFIGKMPVFKKQS 942
              |..::|.|       ||.|..           .::.|:||:        ||         :|.
Human  1413 --EEVILKGS-------PEEKVV-----------LAEKSEPSH--------LP---------EQI 1440

  Fly   943 VPSFNYDASAVYTNGCLEAPPPPPPPLGGATSQIAVRQQAPTAAQIQMAMMEDAFGNAPPFHPDA 1007
            :|                 |||||||.......:.....||:|||....:.           |..
Human  1441 LP-----------------PPPPPPPPPPPPPPVIPHPAAPSAAQANAILA-----------PVK 1477

  Fly  1008 GMMVDYDELMP--------DPVQFANLMTSCPPPPPPGEGSEGDAHGPEDGDQHDNENREDVLPP 1064
            ...|....|.|        :||....:|.|..|...|                      .|...|
Human  1478 SNPVVSQTLSPGFVGPNILNPVLPVAIMASAQPAAIP----------------------SDETAP 1520

  Fly  1065 GIDEAE------SALV--PHPLDAAAQSRDGELPK--------DLVEALDIIFPS---------- 1103
            |:.|::      |.||  |.||.:....:..:|.|        :..:..||.:.|          
Human  1521 GVSESDRDQTLFSVLVRPPPPLSSVFSEQAKKLEKRNSCLATANAKDLYDIFYSSGGKGAPETKG 1585

  Fly  1104 ---------DVAILEASNGNSEKQEDVTITTIVEDDAVLSVIHLQDLAKEGIHLVTINEAEVPKK 1159
                     .:|..|.||.:..|..|.:.|:.:...|....:| ||.......:|:.:|..:.|.
Human  1586 APETKLSGGPLANGENSNLSRTKSSDTSSTSPLNSSASQEELH-QDEGLVAAPIVSNSEKPIAKT 1649

  Fly  1160 ----------SHI---QTSEKIEKLQDL-------------------------NGKSDDGVNIKL 1186
                      .|:   .|......||.|                         :.:||...:|..
Human  1650 LVALGKWSVVEHVGPKSTGSTYGFLQPLTRLCQSRPYETITPKTDTLAIWTSSSFQSDTSRDISP 1714

  Fly  1187 IDAE-DIPMPNSPPAEPS---FDEETKSKALQKQADISEIPEPAVSPSDSEKLR-----RQSELD 1242
            ..:| |:..|..|..||.   .|.:.|..  ||..:| .:.|......:|::||     |:||::
Human  1715 EKSELDLGEPGPPGVEPPPQLLDIQCKES--QKLVEI-HLRESVNQDKESQELRKSEDCRESEIE 1776

  Fly  1243  1242
            Human  1777  1776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9776NP_649455.1 bZIP <289..322 CDD:473870 11/37 (30%)
ZnF_U1 546..577 CDD:197732 10/30 (33%)
ZNF318NP_055160.2 Interaction with AR. /evidence=ECO:0000250|UniProtKB:Q99PP2 1..1092 129/583 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..140
PHA03307 <52..>143 CDD:223039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 164..189
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 279..346
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..416
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 514..533
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..570
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 664..709 12/52 (23%)
PHA03377 <684..876 CDD:177614 40/214 (19%)
PTZ00121 <877..1346 CDD:173412 118/513 (23%)
MAD 881..>997 CDD:461677 28/129 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 922..942 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 989..1051 20/71 (28%)
ZnF_U1 1063..1097 CDD:197732 9/36 (25%)
ZnF_U1 1133..1167 CDD:197732 10/33 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1195..1319 29/132 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1428..1463 14/68 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1577..1628 8/50 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1702..1735 9/32 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1753..1775 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2252..2279
Blue background indicates that the domain is not in the aligned region.

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