DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9776 and znf318

DIOPT Version :9

Sequence 1:	NP_649455.1	Gene:	CG9776 / 40546	FlyBaseID:	FBgn0027866	Length:	1260	Species:	Drosophila melanogaster
Sequence 2:	XP_002664136.3	Gene:	znf318 / 100330539	ZFINID:	ZDB-GENE-140106-251	Length:	2230	Species:	Danio rerio

Alignment Length:	1540	Identity:	327/1540 - (21%)
Similarity:	515/1540 - (33%)	Gaps:	492/1540 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 HDLLP--GPPGVDEKSGNENCE--------------------------PRSSGSGKRGKSNSRRR 57
            ||..|  ||..|..:|..|..|                          .|..||....|:..||:
Zfish   485 HDFPPGVGPQDVTVRSEVEEYEKIQDLLKTIGLDLGVAEISKMAARTQERLHGSVPAKKTPVRRQ 549

  Fly    58 STSRGRSDSRNTSPSNTRRRHSLSRSLTPPRRRYDSPDYGRYSRRRFDRDRRRSPERRRSPPRRG 122
            |..:.||.||::|.|:.....|.|||.:..|.|              .|.|.||.....:.
Zfish   550 SDRKHRSRSRSSSSSSGSGSRSSSRSQSESRSR--------------SRSRSRSGSLNHTS---- 596

  Fly   123 RRYGRSRSRSMSPRRGGR--WSPKKKPSSPPVP-----------------------PPHGGPHPQ 162
               .||:.:|:||.:...  .|..||.:.|.||                       ||:.||.|:
Zfish   597 ---SRSKKKSVSPEKASPHVHSQSKKDTQPAVPESNWPTTPTPAQSYPSRPGVLPHPPYPGPPPR 658

  Fly   163 MTPGYGAMAAHIYGSYVAPPDVYGHQYGIPPNSFPPQGPGYGIPGAPPDQSSFGSGYGPPPTSAW 227
                           .:.|||...|.||...|..|...||:  |..||      :|...||
Zfish   659 ---------------EIMPPDYRTHGYGAYGNYIPYMPPGW--PMYPP------TGMPVPP---- 696

  Fly   228 DVNVYGQQVWINQPISGVQPSASDSLIQPQKARETLSGKTIGEEQSVPALEGAGLTPQ--DAVAQ 290
                               ||..|....|...|..|  |||....|....:.....|.  ||||.
Zfish   697 -------------------PSQIDPYSLPNMERPFL--KTIKNVTSESKADNTKKAPSKLDAVAS 740

  Fly   291 EA------------------EKQK------------DELKKQRANYVKKVSLLKKEM-KVLKDQR 324
            :|                  :|||            |..:|::.|.:|.|..|:|:. ::|:.:|
Zfish   741 KAITTDHFQRKEMEDKNTASQKQKVTEELEKLRMERDVRQKRKENLLKDVETLRKQQGELLRKKR 805

  Fly   325 EDLAAGDAPPSPTTKNFIEENDRLQMQIKKKLDTIENVIDMLNGIIGYEEVEDEPSNQKSHGKTQ 389
            .:   .|....|    .:.|..|||.....::..:.:              |.:.::||.....:
Zfish   806 RE---KDGHKDP----LLVELGRLQEDAMAQISKLRS--------------EQKEADQKHEELVK 849

  Fly   390 --------PEQQDSRSHSSSESSADSSESSSSSSTASDSSSDNEDGEGAGGAVGSPTNRLKHRAI 446
                    .|.:.|.:||..:|. ||:.|...|...:::|                     :..:
Zfish   850 VALILGIDKEWKISSAHSQQQSK-DSARSPEKSVAKTNTS---------------------YNKV 892

  Fly   447 KSMKSKQLHGEMKAVPTQAQN------YNFVFFDPEQHWCESCGVFPKSARDYLKHLHAEEHMNR 505
            .|:||:....::|..|..:.:      ..|.::|...|||::|.|...|..||..|||::.|  |
Zfish   893 ASLKSRASPEKLKESPLSSSHSLDTAAEQFEYYDAGNHWCKNCNVTGGSMFDYFMHLHSKTH--R 955

  Fly   506 ETI---ETPWHVGIDHDPFPTFENAPARR---VPVRGMQFLVPANAWFCKLCSVWIGDLHCASAH 564
            :|:   :.||      ....:.:..||.:   .|.:|.:||||...:||:||..:.||..||.:|
Zfish   956 KTLDPYDRPW------AKTESEKKGPAGKKTSKPAKGSEFLVPVRGFFCQLCEEFFGDPICAESH 1014

  Fly   565 LKSRLHSNKYQQFLNQNPNYEIEWQTNRERAMNQQK-----------DHDDAKNKKSKKD----- 613
            :....|:.||:..|.:||.||...:.:|:..:..||           |.||.|..|..|:
Zfish  1015 VTCHTHNEKYKAKLYENPLYEQRRKLDRQAGLESQKSSVLKRKHEDDDQDDVKKSKYNKEGKLSS 1079

  Fly   614 ---EDKASKKRKKKGGDKKKKKRKHGKKSKRSTIDANSTSSSSDSSS---SEEENGQQPKKGRTE 672
               :.|....:::...|.|:...||..|.|:...|........|..:   .|||...:.||...|
Zfish  1080 NAMDTKPQYSKEEDHRDIKENDSKHKDKYKKDEYDKLKYKEEEDERARIKKEEEEKSRYKKDDDE 1144

  Fly   673 QQPICQSDKSTNAASIRVAMRKQES---------------------------------------T 698
            :...    |.....|.|...|:.||                                       :
Zfish  1145 RNRY----KKEEECSRRYRKREGESSRYEEDHYRNRDDDDDEYHRYKDDDDRYRYRKDDDRGRYS 1205

  Fly   699 PTNLKPEVPCQPVVPPPPPIIKDSTIPSER-------------GKWTAAS-VEDQ-------SKD 742
            ..:.||....:          :|......|             |||..:. .|||       .||
Zfish  1206 REDEKPRYDKE----------EDKRYKYTREVEEKSKYKGENWGKWPKSKWDEDQESGGKFDKKD 1260

  Fly   743 QKN----------RDDTMLKQWNNVQPVISESEK-----KLL----EQLKGRLKNKGARDQNNHK 788
            .|.          |||......:||:.|.:|.||     |:|    ..|..:|:.|
Zfish  1261 DKTPYQKGKAGLFRDDKASAGMSNVKDVKTEPEKPIEPPKILCGPSPALLAKLRKK--------- 1316

  Fly   789 AVPTEANDEKFRRGG-GRHSRSRSKRRSYSRSISRGRDRDRRDRERDRDRGRRRRSRSRGRHFSR 852
                  |:|...|.| |:.||.:.::.:..:...|...:..::.|.:::       ......||:
Zfish  1317 ------NEEAAGRPGFGKFSRKKPQKTALEKEAERMAAQFLKEDEVEKE-------EEELDPFSK 1368

  Fly   853 SPIRSSRRSRSRQGR------------SRRSRSRSIERVERPVVKHSEFRPRTVPERKQTDIKRD 905
            |...:...:....|:            :....:.::.....|:|....|  ..||.:.......|
Zfish  1369 SVAAAKSIAIKLTGKAMIPPSGEWLAFNENKSNTNLPPPLSPMVIRKSF--SGVPNKPTPPALSD 1431

  Fly   906 K-------------KDAESKSKSSKPSNNSLPGGKKLPFIGKMPVFKKQSVPSFNYDASAVYTNG 957
            |             ..|:..||:.......|...|.|.  ..:.:|.|.:.|.|. ..|.:.::.
Zfish  1432 KFPAPLTGTQKGTALSADLISKAFSGEEVQLKQAKLLE--SPVEIFNKPAPPPFP-TPSPISSSA 1493

  Fly   958 CLEAPPPPPPPLGGATSQIAVRQQAPTAAQIQMAMMEDAFGN--------APPFHPDAGMMVDYD 1014
            ...|||..|.| ..:::.:.....||::||:.......|..:        |||..|.:
Zfish  1494 PSPAPPSAPSP-APSSAPLPSLSPAPSSAQLPAPASSSALSSTQSSAPSPAPPLVPSS------- 1550

  Fly  1015 ELMPDPV-QFANLMTSCPPPPPPGEGSEGDAHGPEDGDQHDNENREDVLPPGIDEAE--SALV-- 1074
              .|.|: ..|..:|:.|....|.:..      |....:.......||..||:.|.|  ..||
Zfish  1551 --TPPPILSPAPTLTAAPEIVKPSQLK------PVLQPERVVTLESDVAAPGVPEQERKQTLVLR 1607

  Fly  1075 ---PHPLD--------------AAAQSRD--------GELPKDLVEALDIIFPSDVAILEASNGN 1114
               .||.:              ||.:::|        |...|..|.|| ::...|.....:::|:
Zfish  1608 PPPQHPSNVRAQPPKMVKPKTLAAGKAKDLFDIFYSGGTTAKTSVSAL-VVNKQDPGFAHSNSGS 1671

  Fly  1115 SEKQEDVTITTIVEDDAVLSVIHLQDLAKEGIHLVTINEAEVPKK-------------SHIQTSE 1166
            :.|..:      .:|.....:...:.|...|...||.||..:..|             |.|..::
Zfish  1672 TCKNSN------NKDKKACDIFQGKVLPSNGHSQVTANEESLKNKEANVAERKDDNEDSKIAQNK 1730

  Fly  1167 KIEKLQDLN-GKSDDGVNIKLIDA--------EDIPM----------PNSPPAEPSFDEETKSKA 1212
            :..|.:||| .||::..|.:..:.        ||:.:          |....::.||:||....|
Zfish  1731 ESSKNEDLNVVKSEESTNNEYSEVAQSKEPLNEDLDIESKESSKNEDPKVTQSKESFNEEDSEVA 1795

  Fly  1213 LQKQADISEIPEPAVSPSDSEKLRRQSEL--DELAMLGIDRSDMA 1255
            |.|  |.|:......||.::..:...||:  :|..:...| |:||
Zfish  1796 LSK--DSSKSKHLKFSPCENSSVNEDSEVAQNEEGLSNED-SEMA 1837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9776	NP_649455.1	bZIP	<289..322	CDD:304365	13/63 (21%)
CG9776	NP_649455.1	ZnF_U1	546..577	CDD:197732	12/30 (40%)
znf318	XP_002664136.3	ZnF_U1	927..961	CDD:197732	14/35 (40%)
		ZnF_U1	993..1025	CDD:197732	11/31 (35%)
		PHA02896	<1083..>1210	CDD:165222	21/130 (16%)
		Hid1	<1863..1983	CDD:301632
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581489
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28V80
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007912
OrthoInspector	1	1.000	-	-		oto38871
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15577
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7137
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.920