DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt14 and SYTL4

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001357091.1	Gene:	SYTL4 / 94121	HGNCID:	15588	Length:	676	Species:	Homo sapiens

Alignment Length:	307	Identity:	65/307 - (21%)
Similarity:	123/307 - (40%)	Gaps:	48/307 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 LELSLLYDAPMRKMTVHVMQAKNLPPLGSG-QTTHTQVRMLMLPSKKQ--KLKTKI-RSGENPQY 354
            :..||.|:...:.:.|||.:...|...... :.::..|:..:||.|.:  |.||.| |...||.|
Human   360 IAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLY 424

  Fly   355 MESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPR---NT 416
            .|: |.:.:....:....|:..::...|..:...:|||.:...:..|:.:.:..|||..:   .:
Human   425 DET-LRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAES 488

  Fly   417 SSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLLGLSY----------------NGVTGRLSVE 465
            .:||.|                    |.|  ||::.|.|                .|..|.|.|.
Human   489 PTGLPS--------------------HKG--ELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVW 531

  Fly   466 IIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQ-VALFQLNDV 529
            |.:.....:.......|::||..:: .:..:.|:.||.:.:...||.:..||.:. |.|..|..:
Human   532 IKEAKNLTAAKAGGTSDSFVKGYLL-PMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHM 595

  Fly   530 TLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGEM 576
            .|.::|:.:..:..|:.:|...||:.:...:.:.....:|...:|.:
Human   596 CLELTVWDREPLASNDFLGGVRLGVGTVNIQPILIECLLCARTRGRL 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	30/122 (25%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	30/148 (20%)
SYTL4	NP_001357091.1	FYVE_2	8..121	CDD:308117
		FYVE_Slp4	58..107	CDD:277303
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..243
		C2A_SLP-4_5	357..481	CDD:175995	29/121 (24%)
		C2B_SLP_1-2-3-4	496..>622	CDD:175987	29/128 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810