Protein Alignment Syt14 and SYTL4

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_001357091.1
• Gene: SYTL4 / 94121
• HGNCID: 15588
• Length: 676
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 65/307 - (21%)
• Similarity: 123/307 - (40%)
• Gaps: 48/307 - (15%)

  Fly   294 LELSLLYDAPMRKMTVHVMQAKNLPPLGSG-QTTHTQVRMLMLPSKKQ--KLKTKI-RSGENPQY 354
            :..||.|:...:.:.|||.:...|...... :.::..|:..:||.|.:  |.||.| |...||.|
Human   360 IAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLY 424

  Fly   355 MESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPR---NT 416
            .|: |.:.:....:....|:..::...|..:...:|||.:...:..|:.:.:..|||..:   .:
Human   425 DET-LRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAES 488

  Fly   417 SSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLLGLSY----------------NGVTGRLSVE 465
            .:||.|                    |.|  ||::.|.|                .|..|.|.|.
Human   489 PTGLPS--------------------HKG--ELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVW 531

  Fly   466 IIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQ-VALFQLNDV 529
            |.:.....:.......|::||..:: .:..:.|:.||.:.:...||.:..||.:. |.|..|..:
Human   532 IKEAKNLTAAKAGGTSDSFVKGYLL-PMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHM 595

  Fly   530 TLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGEM 576
            .|.::|:.:..:..|:.:|...||:.:...:.:.....:|...:|.:
Human   596 CLELTVWDREPLASNDFLGGVRLGVGTVNIQPILIECLLCARTRGRL 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	30/122 (25%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	30/148 (20%)
SYTL4	NP_001357091.1	PHD_SF	8..121	CDD:473978
		FYVE_Slp4	58..107	CDD:277303
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	199..243
		C2A_SLP-4_5	357..481	CDD:175995	29/121 (24%)
		C2B_SLP_1-2-3-4	496..>622	CDD:175987	29/128 (23%)