DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt14 and SYT16

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001354585.1	Gene:	SYT16 / 83851	HGNCID:	23142	Length:	645	Species:	Homo sapiens

Alignment Length:	594	Identity:	197/594 - (33%)
Similarity:	304/594 - (51%)	Gaps:	76/594 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LFLFISRKCCFHYRHAINCCD--------------ERHLAVKCVQKITRKRRYENTSSDSEE--D 85
            |||.:.     |:    :||:              .:|....|    :...::.|.:||..:  .
Human    84 LFLEVD-----HF----SCCNSDLQDSAQNSSPSLSQHAKDSC----STMSQWPNWASDDRKLPH 135

  Fly    86 ILRRLRWHQQHQLGEKPGGYGLGISQANPLTAQSFN-YHQAGASADLQRVTVSRD-PLAIAERGK 148
            :|..:. .::|.|.::..|...|.....|.|.::.| ..|..:..|.:.::.|.| ...:.::.:
Human   136 VLSSIA-EEEHHLEKQRSGLQHGFDSQLPGTLETVNGKKQVNSFGDDEELSTSSDSDEEVIKQFE 199

  Fly   149 VGIPSSHSECSSNDSMEVSVDSHTGVLTGL------SKATTTVPHPATAFRNPC-----GEHRAK 202
            :.:..|.|        ..||.|..|..|||      |::..|.....|.. :.|     ...|..
Human   200 ISVSRSQS--------FRSVTSEKGKQTGLEQKPKFSRSLLTHGEDGTEV-SACEDLDGASQRRY 255

  Fly   203 TQALRYQHRVNVAAPPKLDKERDNVLVVPMVNAYSINNNNNSITTSNNHPSSNNN---------- 257
            ::.|.|....::.|..:...||.:      ...:..::..:|:..|....|:..:
Human   256 SENLSYGEDDHIPAHSQSPCERGD------AKHHGTSHQESSVVQSLRRQSTEGSLEMETAFNSR 314

  Fly   258 --DDEPLFDTSDLRSIKSDD---LLVGVDQKEPAVQRGPIELELSLLYDAPMRKMTVHVMQAKNL 317
              :|....|:|.:.|.:..|   |.|.....||..:.|  :|::...|.|..:|:||.:::|:.|
Human   315 GFEDSYATDSSSMWSPEEQDRTNLQVPSGVSEPISKCG--DLDVIFEYRAASQKLTVTIVRAQGL 377

  Fly   318 PPLGSGQTTHTQVRMLMLPSKKQKLKTKIRSGENPQYMESFLLHRVNPEDVNNMGLRVRLYGCER 382
            |..........||.:::||.||.:.:|.|:.|.||.:.|.....::.|.||....:|.|||...:
Human   378 PDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGPNPVFREKVTFAKLEPRDVAACAVRFRLYAARK 442

  Fly   383 LRKERLIGEAYVSFATVDLELETNLWLPLEPRNTSSGLGSTSDLLSLARSESAGSTSSMQHGGVS 447
            :.:||::||.....:.:..|.|..:.|.||||:..|..||.....:::.|:|..||.|:.|||..
Human   443 MTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAP 507

  Fly   448 ELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPL 512
            |||:|||||..|||||||:||||.||:|::|:|||||.|:.:::|:|||:||.|||||||||||:
Human   508 ELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPV 572

  Fly   513 FKETFAFQVALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGEML 577
            :||||.||||||||:|||||||||.:|.||:.||:||.:||.||||.||..||.::.| .||:.:
Human   573 YKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKE-TKGQQI 636

  Fly   578 ARWHVLVDS 586
            .|||.|::|
Human   637 CRWHTLLES 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	36/121 (30%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	90/137 (66%)
SYT16	NP_001354585.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..121		2/22 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..192		11/47 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..344		28/152 (18%)
		C2A_Synaptotagmin-14_16	350..473	CDD:176035	37/124 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..503		8/24 (33%)
		C2B_Synaptotagmin-14_16	506..643	CDD:176053	90/137 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	162	1.000	Domainoid score	I3989
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2585
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D339484at33208
OrthoFinder	1	1.000	-	-		FOG0002721
OrthoInspector	1	1.000	-	-		otm40377
orthoMCL	1	0.900	-	-		OOG6_109712
Panther	1	1.100	-	-	LDO	PTHR46129
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5537
SonicParanoid	1	1.000	-	-		X2510
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.000