DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt14 and sytl2a

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_009303749.1	Gene:	sytl2a / 563188	ZFINID:	ZDB-GENE-130723-2	Length:	1447	Species:	Danio rerio

Alignment Length:	536	Identity:	111/536 - (20%)
Similarity:	207/536 - (38%)	Gaps:	94/536 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 WHQQHQLG----EKPGGYGLGISQ------ANPLTAQSFNYHQAGASADLQRVTVSRDPLAIAER 146
            :.|.||.|    ..|..:.|..|:      :...|.::::...|.:..|.:.....:..|..|..
Zfish   950 FEQVHQGGVSNESSPSRHSLLESEEITFDSSGSSTPEAWSISHASSYWDSEDDGPFKAALERANA 1014

  Fly   147 GKVGIPSSHSECSSNDSME-VSVDSHTGVLTGLSKATTTVPHPATAFRNPCGEHRAKTQALRYQH 210
            ..:.|..|..:.:|..|.| ...|....|...:...:...|:..|:|.:|   .:.|..:|
Zfish  1015 RPISISKSLEDLASTPSQERWKTDPRNDVRMSMENVSAVPPNTKTSFSDP---EQVKMMSL---- 1072

  Fly   211 RVNVAAPPKLDKE---RDNVLVVPMVNAYSINNNNNSITTSNNHPSSNNNDDEPLFDT-SDLRSI 271
                :.|..:.:|   |::       :..|:::..|....|.|.||:        |.| |::.|:
Zfish  1073 ----SVPALMQQEMECRNS-------DCASVSSFYNDRQRSCNTPSN--------FSTCSEVASM 1118

  Fly   272 KSDDLLVGVDQKEPAVQRGPIE----LELSLLYDAPMRKMTVHVMQAKNLPPLG-SGQTTHTQVR 331
            .|   :.|......:.:.|.:|    ::.::.|...:.:..:.|:|.|:|.... ....:...|:
Zfish  1119 SS---VTGSVMSIYSSEFGYVEVKGTVQFAIHYVQKLGEFHIFVVQCKDLAVADVKRNRSDPYVK 1180

  Fly   332 MLMLPSKKQ--KLKTKIRSGE-NPQYMESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAY 393
            ..:||.|.:  |.||.:|... :|.|.| .|..::..|.:....|.:.::..:...:...:||..
Zfish  1181 CYLLPDKAKYGKKKTCVRKKTLDPTYNE-ILRFKIPMEMLKTQKLNISVWHNDTFGRNSFLGEVE 1244

  Fly   394 VSFATVDLE--------LETNLWLPLEPRNTSSGLGSTSDLLSLARSESAGSTSSMQHGGVSELL 450
            |..|..|..        |:..:.:|..|:::..|...::::....|.....:.|....|
Zfish  1245 VDLAEWDFNNTQMNEYLLKGRVQIPTSPKHSFGGEEMSAEIKVALRFLPQTTLSHKNKG------ 1303

  Fly   451 LGLSYNGVTGRLSVEI-IKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFK 514
                 ||     .|:| :|..:...:|...|.|.:||..::....:: ||.||.:.:..|||:|.
Zfish  1304 -----NG-----EVQIWVKECKNLPISRGVAIDPFVKCAILPENNRK-SRQKTRVLKRAPNPVFN 1357

  Fly   515 ETFAFQ-VALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGL---NSSGSEEVAHWAD--VCEMPK 573
            .|..:. .....|.|:.:.::|:....: .|..:|...||.   .|.|||  .:|.|  |.|
Zfish  1358 HTMVYDGFGHDDLKDICVELTVWDHDRL-NNHFIGGIRLGPGTGKSYGSE--VNWMDSNVAE--- 1416

  Fly   574 GEMLARWHVLVDSXFE 589
               .|.|..:|.: .|
Zfish  1417 ---AALWERMVQTQNE 1429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	27/137 (20%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	36/144 (25%)
sytl2a	XP_009303749.1	PHD_SF	5..>37	CDD:328929
		C2A_SLP-1_2	1139..1263	CDD:176039	24/124 (19%)
		C2B_SLP_1-2-3-4	1283..1438	CDD:175987	41/173 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900