Protein Alignment Syt14 and SYTL2

DIOPT Version :9

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_996810.2
• Gene: SYTL2 / 54843
• HGNCID: 15585
• Length: 2239
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 115/566 - (20%)
• Similarity: 209/566 - (36%)
• Gaps: 141/566 - (24%)

  Fly    76 ENTSSDSEEDILRRLRWHQQHQLGEKPGGYGLGISQANPLTAQSFNYHQAGASADLQRVTVSRDP 140
            ||::..|:.::.....:.:|.:..||.|......|..|  |:.:....:..:|::.:...|
Human  1726 ENSTKTSKVELTLASPYMKQEKEEEKEGFSESDFSDGN--TSSNAESWRNPSSSEEEPSPV---- 1784

  Fly   141 LAIAERGKV-GIPS-SHSECSSNDSMEVSVDSHTGVLTGLSK----------------ATTTVP- 186
            |...||... .:|| |..:.||:.|.:..||:....|...::                ..:|||
Human  1785 LKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDDEKPDQKPVTNECVPRISTVPT 1849

  Fly   187 HPATAFRNPCGEHRAKTQALRYQHRVNVAAPPKL-----DKERDNVLVVPMVNAYSINNNNNSIT 246
            .|...|.:|        ..|:   |::.:.|..|     |:|.|..    ..::|.::.:..|
Human  1850 QPDNPFSHP--------DKLK---RMSKSVPAFLQDESDDRETDTA----SESSYQLSRHKKS-- 1897

  Fly   247 TSNNHPSSNNNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQRGPI-------ELELSLLYDAPM 304
                 |||..|    |..:|.:.|:.|      |.....:|..|..       .::.::.|...:
Human  1898 -----PSSLTN----LSSSSGMTSLSS------VSGSVMSVYSGDFGNLEVKGNIQFAIEYVESL 1947

  Fly   305 RKMTVHVMQAKNLPPLG-SGQTTHTQVRMLMLPSKKQKLKTK---IRSGENPQYMESFLLHRVNP 365
            :::.|.|.|.|:|.... ..|.:...|:..:||.|.:..|.|   ::...||.|.| .|.:::..
Human  1948 KELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNE-ILRYKIEK 2011

  Fly   366 EDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETN---LWLPLEPRNTSSGLGSTSDLL 427
            :.:....|.:.::..:..::...:||..:...|.|.:.:.|   .|.||:.:.....|
Human  2012 QILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVAL------- 2069

  Fly   428 SLARSESAGSTSSMQHGGVSELLLGLSY--NGVTGR---------------LSVEIIKGSQFRSL 475
               .:|:.|           |:.|.|.|  ..|.|:               |.:.:::||...|
Human  2070 ---EAENRG-----------EMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNS- 2119

  Fly   476 SLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQVALFQLND-VTLMISVYAKR 539
                    :||..::....:: ||.||.......||:|..|..:..  |:..| :...:.:....
Human  2120 --------FVKCTILPDTSRK-SRQKTRAVGKTTNPIFNHTMVYDG--FRPEDLMEACVELTVWD 2173

  Fly   540 HMK-KNEMVGWFSLGLNS------------SGSEEVAHWADVCEMP 572
            |.| .|:.:|...:|..:            |.|||||.|..:...|
Human  2174 HYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSP 2219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	27/135 (20%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	35/158 (22%)
SYTL2	NP_996810.2	PHD_SF	5..>41	CDD:328929
		C2	1934..2061	CDD:326325	26/127 (20%)
		C2B_SLP_1-2-3-4	2074..2230	CDD:175987	36/169 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910