DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt14 and Syt14

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_006497318.1	Gene:	Syt14 / 329324	MGIID:	2444490	Length:	857	Species:	Mus musculus

Alignment Length:	377	Identity:	151/377 - (40%)
Similarity:	219/377 - (58%)	Gaps:	30/377 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 SINNNNNSITTSNNHPSSNN---NDDEPLFDTS-----DLRSIKSDDLLVGVDQKEPAVQRGPIE 293
            |.|...:..:|.:...|.:|   .||.|...|:     |:.:..|...|......||..:.|  .
Mouse   484 SFNKCPSEGSTGHEAESYHNKGYEDDVPSDSTAVLSPEDMSAQGSSSQLPKPFDPEPEAKYG--T 546

  Fly   294 LELSLLYDAPMRKMTVHVMQAKNLPPLGSGQTTHTQVRMLMLPSKKQKLKTKIRSGENPQYMESF 358
            |:::..||:..:|:.|.|....::|..........||.:::||.|||:.||.|:.|..|.:.|:|
Mouse   547 LDVTFDYDSERQKLLVTVTAVTDIPTYNRTGGNSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETF 611

  Fly   359 LLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPRNTSSGLGST 423
            ..:.|..|.:.|..:|.||||..|::||:::||.......::|:.:.:|.:.|||....||..|.
Mouse   612 KFNHVESEMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNPSGCDSQ 676

  Fly   424 SDLLSLARSESAGSTSSMQHGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAP------- 481
            ..|...:..:|..|..|:|||.|.|:|:||.||..|||||.|:||||.|::|:.|:.|
Mouse   677 VSLSEASCGDSTSSCQSLQHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRPPNGLFCCL 741

  Fly   482 ------------DTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQVALFQLNDVTLMIS 534
                        |||||:.:::|:|||:|:.|||.|||||||::||||.||||||||:||||::|
Mouse   742 KHLIGGQVYIIRDTYVKLTLLNSMGQEMSKCKTSTRRGQPNPVYKETFVFQVALFQLSDVTLILS 806

  Fly   535 VYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGEMLARWHVLVDS 586
            ||.:|.||:.||:||.||||||||.||:.||..:.| .||:.:.|||.|::|
Mouse   807 VYNRRSMKRKEMIGWISLGLNSSGEEELRHWTAMKE-SKGQQVCRWHALLES 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	37/121 (31%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	85/156 (54%)
Syt14	XP_006497318.1	C2A_Synaptotagmin-14_16	543..666	CDD:176035	38/122 (31%)
Syt14	XP_006497318.1	C2B_Synaptotagmin-14_16	699..855	CDD:176053	84/154 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I4043
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2607
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002721
OrthoInspector	1	1.000	-	-		otm42447
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46129
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5537
SonicParanoid	1	1.000	-	-		X2510
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.950