DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt14 and Rph

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster

Alignment Length:	602	Identity:	124/602 - (20%)
Similarity:	238/602 - (39%)	Gaps:	116/602 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 RHAI----NCC-----------DERHLAVKCVQKITRK------RRYENTSSDSEEDILRRLRWH 93
            :||:    |||           .:|.|...|.|.:..|      .|| :||..|.|..|.|: ..
  Fly    78 QHAVERGPNCCRLCGDTFGILRPQRILCEDCRQSVCTKCSVDINIRY-HTSERSREIWLCRI-CS 140

  Fly    94 QQHQLGEKPGGY---GL------GISQANPLTAQSFNYHQAGASADLQRVTVSRDPLAIAERGKV 149
            :..::.:|.|.:   ||      ..:.|.|:...... ..||.:..:|....:....|..::..:
  Fly   141 ETREMWKKSGAWFFKGLPKYDMPRSASATPIPNPGPG-SMAGDTRAVQSCHATPTRPARVKKLTI 204

  Fly   150 GIPSSHSECSSNDSMEVSVDSHTGVLT-----GLSK--ATTTVPHPATAFR-------------- 193
            .:..|.|..|.:...|..||:..|:..     |::|  |:|.:.. ..:||
  Fly   205 RVNDSSSSSSGHSEPEDEVDTGVGIGVGVVGGGMAKGIASTRLQR-EDSFRLRAYGSIRSFIDGG 268

  Fly   194 -----NPCGEHRAKTQALRYQHRVNVAAPPKLDKERDNVLVVPMVNAYSINNNNNSITTSNNHPS 253
                 |....:|.::|........:..:..||.:|...:....:.:::||::::.|  .|||
  Fly   269 ERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGS--GSNN--- 328

  Fly   254 SNNNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQ---RGPI--ELELSLLYDAPMRKMTVHVMQ 313
            |.|:..:..:                 .|.:..:|   |.|:  .||:::.|......:...:::
  Fly   329 SGNSQTQSQY-----------------QQHQQQLQQHCRDPLLGWLEIAISYREAFHSLDCTMVR 376

  Fly   314 AKNLPPLGSGQTTHTQVRM-LMLP------SKKQKLKTKIRSGENPQYMESFLLHRVNPEDVNNM 371
            |::||.:.:........:: ::.|      ::.|:.|| :....||::.|:.....|.||::.|.
  Fly   377 ARDLPAMDAAGLADPYCKLNIITPEAHTKYTRWQRTKT-VHKTRNPEFNETLQFVGVEPEELGNS 440

  Fly   372 GLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPRNTSSGLGSTSDLLSLARSESAG 436
            .:.|.|:..::...: .:|.|.|..:||....:..:.:||.                 ...:.:.
  Fly   441 LIYVALFDDDKYGHD-FLGAAKVCLSTVHSTSQYRISVPLG-----------------VEDQYSN 487

  Fly   437 STSSMQHGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAK 501
            :....|:....::||.|.||.....|.|.:.:.....::..|.:.|.:|| :.:.....:..:.|
  Fly   488 AAEMAQNWPNGKMLLSLCYNTKRRALVVNVKQCINLMAMDNNGSSDPFVK-IQLKPDAHKNKKHK 551

  Fly   502 TSIRRGQPNPLFKETFAFQVALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWA 566
            ||::....||::.|.|.|:.:...||...|:::|:.|...|.|:.:|...||..|.| |.:..|.
  Fly   552 TSVKWRTLNPIYNEEFYFEASPHDLNKEMLILTVWDKDLGKSNDFLGSLQLGAQSKG-ERLQQWL 615

  Fly   567 DVCEMPKGEMLARWHVL 583
            |...:| .....:||.|
  Fly   616 DCIRLP-DHFHEKWHCL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	27/130 (21%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	38/138 (28%)
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600	22/89 (25%)
		C2A_Rabphilin_Doc2	354..477	CDD:176000	24/124 (19%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	37/134 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468149
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840