DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt14 and Syt16

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_234300.4	Gene:	Syt16 / 299142	RGDID:	1564654	Length:	644	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	183/546 - (33%)
Similarity:	273/546 - (50%)	Gaps:	122/546 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 NTSSDSEEDILRRLRWHQQHQLGEKPGGYGLGISQANPLTAQSF--NYHQAGASADLQRVTVSRD 139
            :|||:|:||:.::               :.:.:|:     :|||  ...:.|.:.:|::.|..:.
  Rat   185 STSSESDEDVTKQ---------------FEISVSR-----SQSFRTGVPEKGKTTELEQKTKCKH 229

  Fly   140 PLAIAERGK--------VGIPS--SHSECSSNDSMEVSVDSHT-----------------GVLTG 177
            .|...:...        :..||  |:||..|.:...:|:.|.:                 ||:..
  Rat   230 FLCTHQEDSAEGSACEDLDGPSQLSYSEIRSYEDRPISILSQSPCESRDTRHHGPCHLGAGVVRN 294

  Fly   178 LSK------ATTTVPHPATAFRNPCGEHRAKTQALRYQHRVNVAAPPKLDKERDNVLVVPMVNAY 236
            ||:      ..|.....:..|.:|...|.:...:...|...::..||:|.:
  Rat   295 LSRPCADGILETETAFISRGFEDPYATHNSSMWSPEEQDGTSLQVPPRLPE-------------- 345

  Fly   237 SINNNNNSITTSNNHPSSNNNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQRGPIELELSLLYD 301
                           |.|...|.:.:|:                                   |.
  Rat   346 ---------------PISKCGDLDVIFE-----------------------------------YR 360

  Fly   302 APMRKMTVHVMQAKNLPPLGSGQTTHTQVRMLMLPSKKQKLKTKIRSGENPQYMESFLLHRVNPE 366
            |..:|:||.:::|:.||..........||.:::||||||:.||.|:.|.||.:.|.....::.|.
  Rat   361 AVTQKLTVTIVRAQGLPDKDRSGVNSWQVHIVLLPSKKQRGKTNIQRGPNPVFKEKVTFTKLEPR 425

  Fly   367 DVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPR-NTSSGLGSTSDLLSLA 430
            ||....:|.|||...::.:||::||.....:.:..|.|..:.|.|||| |.|||....|..: ::
  Rat   426 DVAACAVRFRLYAARKMTRERMMGEKLFCLSHLHPEGEMKVTLVLEPRSNLSSGESPLSPSV-VS 489

  Fly   431 RSESAGSTSSMQHGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQ 495
            .|:||.||.|:.||||.|||:|||||..|||||||:||||.||:|:.|:|||||.|:.:::.:||
  Rat   490 HSDSASSTQSLSHGGVPELLVGLSYNATTGRLSVEMIKGSHFRNLAANRAPDTYGKLFLLNCVGQ 554

  Fly   496 EISRAKTSIRRGQPNPLFKETFAFQVALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSE 560
            |:||.|||||||||||::||||.||||||||:|||||||:|::|.||:.||:||.:||.||||.|
  Rat   555 EMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISIYSRRTMKRKEMIGWIALGQNSSGEE 619

  Fly   561 EVAHWADVCEMPKGEMLARWHVLVDS 586
            |..|| |..:..|.:.:.|||.|::|
  Rat   620 EQEHW-DEMKDSKSQQICRWHTLLES 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	38/121 (31%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	88/137 (64%)
Syt16	XP_234300.4	C2A_Synaptotagmin-14_16	349..472	CDD:176035	40/157 (25%)
Syt16	XP_234300.4	C2B_Synaptotagmin-14_16	505..642	CDD:176053	88/137 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I3955
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2639
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D339484at33208
OrthoFinder	1	1.000	-	-		FOG0002721
OrthoInspector	1	1.000	-	-		otm44512
orthoMCL	1	0.900	-	-		OOG6_109712
Panther	1	1.100	-	-	LDO	PTHR46129
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2510
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970