DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt14 and Sytl1

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_006239075.1	Gene:	Sytl1 / 297872	RGDID:	1310715	Length:	562	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	136/571 - (23%)
Similarity:	216/571 - (37%)	Gaps:	121/571 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 TSSDSE--EDILRR---LRWHQQHQLGEKPGGYGLGISQANP-----LT------AQSFNYHQAG 126
            |..:.|  .|:|:|   ||..::.::.:      |..|.|:|     ||      |:|..:|.|.
  Rat    38 TEEEQEAISDVLKRDAHLRQLEEGRVSK------LRASLADPWQLKILTGDWFQEARSQRHHHAH 96

  Fly   127 ASADLQRVTVSR---------------------DPLAIAERG---KVGIPSSHSECSSNDSMEVS 167
            ..:||.|.::.|                     |.:..||..   ||..|.:|:|....|.
  Rat    97 FGSDLVRASIRRKKSSKGDQALGSDGDGEAAGEDTIEEAEPRVSIKVAAPETHTETQEPDF---- 157

  Fly   168 VDSHTGVLTGLSKATTTVPHPATAFRNPCGEHRAKTQALRYQHRVNVA-APPKLDKERD---NVL 228
              |...|||.:|..                |...:.|....|..|.|| |.|:||.|::   ...
  Rat   158 --SSPYVLTKVSSQ----------------EEEPQDQEAPGQGGVQVAEADPELDPEQEAEQESW 204

  Fly   229 VVPMVNAYSINNNNNSITTSNNHPSSNNNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQRGPIE 293
            ..|.    .|...:..:......|....:.|..|..:|.:.|:.|..|...:.......:.||::
  Rat   205 PTPA----QIKTTSKVLENGEETPGLGPSLDRMLSSSSSVSSLNSSTLSGSLKSLSGEAEAGPVQ 265

  Fly   294 LE----LSLLYDAPMRKMTVHVMQAKNLPPLGSGQTTHTQVRMLMLPSKKQKLKTKIRSGE-NPQ 353
            :.    .||.|:....::.|.|:|.:.| .....:.:...|:..:||.|:.|.||.::... ||.
  Rat   266 VRGSVLFSLRYEPGTGELRVQVIQCQGL-AAARRRRSDPYVKSYLLPDKQNKRKTSVKKRNLNPI 329

  Fly   354 YMESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPR-NTS 417
            :.|: |.|.|...|:....|.:.::..|.|.:...:||..|...|.:.:.|.. ||||:|| .||
  Rat   330 FNET-LRHSVQQADLPGRVLSLSVWHRESLGRNIFLGEVEVPLDTWNWDSEAT-WLPLQPRIPTS 392

  Fly   418 SGLGSTSDLLSL------ARSESAGSTSSMQ-HGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSL 475
            .....:..||||      |.||..|...|.: |..:.| ..||          |.:..||.
  Rat   393 PDELPSRGLLSLSLKYIPAGSEGGGQPPSGELHFWIKE-AQGL----------VPLRPGSL---- 442

  Fly   476 SLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQ-VALFQLNDVTLMISVYAKR 539
                  |||::..::.. ....||.:|.:.|...:|:|..|..:. .....|......:|::...
  Rat   443 ------DTYIQCSVLPD-DSRASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHG 500

  Fly   540 HMKKNEMVGW-FSLGLNSSGSEEVAHWADVCEMPKGEMLARWHVLVDSXFE 589
            .:...::.|. .|||..||...:|. |.|  ..|:.:.|  |..|::...|
  Rat   501 ALASRQLGGTRLSLGTGSSYGLQVP-WMD--STPEEKQL--WQTLLEQPCE 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	34/126 (27%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	30/139 (22%)
Sytl1	XP_006239075.1	PHD_SF	35..>70	CDD:419867	8/37 (22%)
		C2	267..386	CDD:417471	32/121 (26%)
		C2B_SLP_1-2-3-4	399..555	CDD:175987	42/175 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810