DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt14 and Sytl4

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_038785.1	Gene:	Sytl4 / 27359	MGIID:	1351606	Length:	673	Species:	Mus musculus

Alignment Length:	337	Identity:	75/337 - (22%)
Similarity:	143/337 - (42%)	Gaps:	46/337 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 ELELSLLYDAPMRKMTVHVMQAKNLPPLGSG-QTTHTQVRMLMLPSKKQ--KLKTKI-RSGENPQ 353
            ::..||.::...:.:.:||.:...|...... :.::..|:..:||.|.:  |.||.| |...||.
Mouse   361 KIAFSLKFEQKTQTLVIHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPL 425

  Fly   354 YMESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPR---N 415
            |.|:| .:.::...:....|:..::...|..:...:|||.|...:..|:.:.:..|||..:   .
Mouse   426 YDETF-RYEISESLLAQRTLQFSVWHHGRFGRNTFLGEAEVHMDSWKLDKKLDHCLPLHGKISTE 489

  Fly   416 TSSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLLG----LSYNGVTGRLSVEIIKGSQFRSLS 476
            :|.||.:....|.:          |:::...|:|.:|    .|..|..|.|.|.|.:.....:..
Mouse   490 SSPGLPAHKGELVV----------SLKYIPASKLPVGGDRKKSKGGEGGELQVWIKEAKNLTAAK 544

  Fly   477 LNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQ-VALFQLNDVTLMISVYAKRH 540
            .....|::||..:: .:..:.|:.||.:.:...:|.:..||.:. |.|..|..:.|.::|:.:..
Mouse   545 SGGTSDSFVKGYLL-PMRNKASKRKTPVMKKTLSPHYNHTFVYNGVRLEDLQHMCLELTVWDREP 608

  Fly   541 MKKNEMVGWFSLGLNSSGSE-EVAHWADVCEMPKGEMLARWHVLVDSXFEQLGQSSG-------- 596
            :..|:.:|...||:.:..|. ||..|.|    ..||.::.|        :::.|..|
Mouse   609 LASNDFLGGVRLGVGTGISNGEVVDWMD----STGEEVSLW--------QKMRQYPGSWAEGTLQ 661

  Fly   597 -RSGKALRKLSL 607
             ||....:||.:
Mouse   662 LRSSMVKQKLGV 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	29/123 (24%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	35/143 (24%)
Sytl4	NP_038785.1	PHD_SF	8..121	CDD:389947
		FYVE_Slp4	58..107	CDD:277303
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..253
		C2A_SLP-4_5	359..483	CDD:175995	28/122 (23%)
		C2B_SLP_1-2-3-4	498..663	CDD:175987	39/187 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810