DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt14 and SYT14

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_006711325.1	Gene:	SYT14 / 255928	HGNCID:	23143	Length:	864	Species:	Homo sapiens

Alignment Length:	349	Identity:	145/349 - (41%)
Similarity:	212/349 - (60%)	Gaps:	22/349 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 NDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQRGPIELELSLLYDAPMRKMTVHVMQAKNLPPLG 321
            :|...:....|:.:..|...|......||..:.|  .|:::..||:..:|:.|.|....::|...
Human   519 SDSTAVLSPEDMSAQGSSSQLPKPFDPEPEAKYG--TLDVTFDYDSQEQKLLVTVTAVTDIPTYN 581

  Fly   322 SGQTTHTQVRMLMLPSKKQKLKTKIRSGENPQYMESFLLHRVNPEDVNNMGLRVRLYGCERLRKE 386
            .......||.:::||.|||:.||.|:.|..|.:.|:|..:.|..|.:.|..:|.||||..|::||
Human   582 RTGGNSWQVHLVLLPIKKQRAKTSIQRGPCPVFTETFKFNHVESEMIGNYAVRFRLYGVHRMKKE 646

  Fly   387 RLIGEAYVSFATVDLELETNLWLPLEPRNTSSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLL 451
            :::||.......::|:.:.:|.:.|||....||..|...:..::.|||..|..|::||.|.|:|:
Human   647 KIVGEKIFYLTKLNLQGKMSLPVILEPSYNHSGCDSQMSVSEMSCSESTSSCQSLEHGSVPEILI 711

  Fly   452 GLSYNGVTGRLSVEIIKGSQFRSLSLNKAP-------------------DTYVKMVMVSSIGQEI 497
            ||.||..|||||.|:||||.|::|:.|:.|                   |||||:.:::|:|||:
Human   712 GLLYNATTGRLSAEVIKGSHFKNLAANRPPNGLFCCLKHLIGGQVYIIRDTYVKLTLLNSMGQEM 776

  Fly   498 SRAKTSIRRGQPNPLFKETFAFQVALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEV 562
            |:.|||||||||||::||||.||||||||:||||::|||.||.||:.||:||.||||||||.||:
Human   777 SKCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNKRSMKRKEMIGWISLGLNSSGEEEL 841

  Fly   563 AHWADVCEMPKGEMLARWHVLVDS 586
            .||.::.| .||:.:.|||.|::|
Human   842 NHWTEMKE-SKGQQVCRWHALLES 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	37/121 (31%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	87/156 (56%)
SYT14	XP_006711325.1	C2A_Synaptotagmin-14_16	550..673	CDD:176035	38/124 (31%)
SYT14	XP_006711325.1	C2B_Synaptotagmin-14_16	706..862	CDD:176053	87/156 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	162	1.000	Domainoid score	I3989
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2585
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D339484at33208
OrthoFinder	1	1.000	-	-		FOG0002721
OrthoInspector	1	1.000	-	-		otm40377
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46129
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5537
SonicParanoid	1	1.000	-	-		X2510
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	11.000