Protein Alignment Syt14 and PLA2G4F

DIOPT Version :9

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_998765.3
• Gene: PLA2G4F / 255189
• HGNCID: 27396
• Length: 849
• Species: Homo sapiens
• Alignment Length: 676
• Identity: 136/676 - (20%)
• Similarity: 209/676 - (30%)
• Gaps: 240/676 - (35%)

  Fly    18 IEVTTLLGAFFGVLVLLLLLFLFISRKCCFHYRHA--INCCDERHLAVKCV-------------- 66
            :|:|.......|...|.||||...|.||...::|.  :|..|.:.|.|:.|
Human   110 LELTLYDKDILGSDQLSLLLFDLRSLKCGQPHKHTFPLNHQDSQELQVEFVLEKSQVPASEVITN 174

  Fly    67 --------QKITRKRRYENTSSDSEEDILRRLRWHQQHQLGEKPGGYGLGISQANPL-------T 116
                    .:|....|.:.|:...|..       .:|.||. .||.|..  .|..||       .
Human   175 GVLVAHPCLRIQGTLRGDGTAPREEYG-------SRQLQLA-VPGAYEK--PQLLPLQPPTEPGL 229

  Fly   117 AQSFNYH--------------------QAGASADLQRVT---------VSRDPL--------AIA 144
            ..:|.:|                    |:|.||:|:..|         :|..||        |:.
Human   230 PPTFTFHVNPVLSSRLHVELMELLAAVQSGPSAELEAQTSKLGEGGILLSSLPLGQEEQCSVALG 294

  Fly   145 ERGKVGIPSSHSECSSND-SMEVSVDSHTGVLTGLSKATTTVPHPATAFRNPCGEHRAKTQALRY 208
            |..:|.: |...|.||.| .:.:..|...|....|.:....|   :.|.:...|...|
Human   295 EGQEVAL-SMKVEMSSGDLDLRLGFDLSDGEQEFLDRRKQVV---SKALQQVLGLSEA------- 348

  Fly   209 QHRVNVAAPPKLDKERDNVLVVPMVNAYSINNNNNSITTSNNHPSSNNNDDEPLFDT-SDLRSIK 272
                       ||..:     ||:|..  :.:...:...|:.:.|.....:..|.|| :.|..:.
Human   349 -----------LDSGQ-----VPVVAV--LGSGGGTRAMSSLYGSLAGLQELGLLDTVTYLSGVS 395

  Fly   273 SDDLLVGVDQKEPA----VQRGPIELELSLLYDAPMRKMTVHVMQAKNLPPLGSGQTTHTQVRML 333
            .....:....::||    ..:||||            :..|||..:|    :|:..|...|.
Human   396 GSTWCISTLYRDPAWSQVALQGPIE------------RAQVHVCSSK----MGALSTERLQY--- 441

  Fly   334 MLPSKKQKLKTKIRSGENPQYME------SFLLHR-VNPEDVNNMGLRVR-------LYGCERLR 384
                ..|:|..:.|||.:...::      .:||:: .||..:::....||       :|....:|
Human   442 ----YTQELGVRERSGHSVSLIDLWGLLVEYLLYQEENPAKLSDQQEAVRQGQNPYPIYTSVNVR 502

  Fly   385 KERLIGE-------------------AYVSFATVDLELETNLWLPLEPRNT--------SSGLGS 422
             ..|.||                   |||.......||.....|.|:|...        .|...:
Human   503 -TNLSGEDFAEWCEFTPYEVGFPKYGAYVPTELFGSELFMGRLLQLQPEPRICYLQGMWGSAFAT 566

  Fly   423 TSDLLSLARSESAGS--------------TSSMQ-----------------HGGVSELLLGLSYN 456
            :.|.:.|   ::|||              |...|                 .|..|:.:|.:..:
Human   567 SLDEIFL---KTAGSGLSFLEWYRGSVNITDDCQKPQLHNPSRLRTRLLTPQGPFSQAVLDIFTS 628

  Fly   457 GVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPL--------- 512
            ..|...|....:|     |.|:|   .||       .|:|....|.:.....||.|
Human   629 RFTSAQSFNFTRG-----LCLHK---DYV-------AGREFVAWKDTHPDAFPNQLTPMRDCLYL 678

  Fly   513 ----FKETFAFQVALFQLNDVTLMIS 534
                |.....|.:||.....|.|::|
Human   679 VDGGFAINSPFPLALLPQRAVDLILS 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	33/154 (21%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	23/102 (23%)
PLA2G4F	NP_998765.3	C2_cPLA2	46..163	CDD:176001	17/52 (33%)
		PLAc	295..791	CDD:214474	94/481 (20%)
		cPLA2_Grp-IVB-IVD-IVE-IVF	303..845	CDD:132840	91/472 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900