DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt14 and Syt16

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_001351210.1	Gene:	Syt16 / 238266	MGIID:	2673872	Length:	654	Species:	Mus musculus

Alignment Length:	556	Identity:	195/556 - (35%)
Similarity:	294/556 - (52%)	Gaps:	78/556 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 CDERHLAVKCVQKITRKRRYE--------NTSSDSEEDILRRLRWHQQHQLGEKPGGYGLGISQA 112
            |..:| ....::|:..:::..        :|||:|:||:.::.:               :.:|:
Mouse   152 CGRQH-GSGTLEKVNGRKQVNSFGDDEEPSTSSESDEDVTKQFK---------------ISVSR- 199

  Fly   113 NPLTAQSF--NYHQAGASADL-QRVTVSRDPLAIAERGKVGIPSSHSECSS--------NDSMEV 166
                :|||  ...:.|.:.:| |::...|......|....|.......||:        ||....
Mouse   200 ----SQSFRSGVSEKGKTTELEQKIKCKRLLCTHQEDSAEGSACEGIHCSALHCRQGQVNDLDRT 260

  Fly   167 SVDSHTGVLTGLSKATTTVPHPATAFRN-----PCGEHRAKTQALRYQHRVNVAAPPKLDKERDN 226
            |..|::.:|:...:..:.:|......||     ||.......::|         ..|..|.
Mouse   261 SQLSYSEILSYEDRPISILPQSPFESRNVRHHGPCRPEMGMVRSL---------GRPCADG---- 312

  Fly   227 VLVVPMVNAYSINNNNNSITTSNNHPSSNNNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQRGP 291
              |:....|:......:|..|   |.||..:.:|     .|..|::....|:     ||..:.|
Mouse   313 --VLETETAFVSRGFEDSYAT---HSSSLWSPEE-----QDGTSLQVPHRLL-----EPISKCG- 361

  Fly   292 IELELSLLYDAPMRKMTVHVMQAKNLPPLGSGQTTHTQVRMLMLPSKKQKLKTKIRSGENPQYME 356
             :|::...|.|..:|:||.:::|:.||..........||.:::||||||:.||.|:.|.||.:.|
Mouse   362 -DLDVIFEYRAVTQKLTVTIVRAQGLPDKDRSGVNSWQVHIVLLPSKKQRGKTNIQRGPNPVFKE 425

  Fly   357 SFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPR-NTSSGL 420
            .....::.|.||.:..:|.|||...::.:||::||.....:.:..|.|..:.|.|||| |.|||.
Mouse   426 KVTFTKLEPRDVASCAVRFRLYAARKMTRERMMGEKLFCLSHLHPEGEMKVTLVLEPRSNLSSGE 490

  Fly   421 GSTSDLLSLARSESAGSTSSMQHGGVSELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYV 485
            ...|..: ::.|:||.||.|:.||||.|||:|||||..|||||||:||||.||:|:.|:|||||.
Mouse   491 SPLSPSV-VSHSDSASSTQSLSHGGVPELLVGLSYNATTGRLSVEMIKGSHFRNLAANRAPDTYG 554

  Fly   486 KMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQVALFQLNDVTLMISVYAKRHMKKNEMVGWF 550
            |:.:::.:|||:||.|||||||||||::||||.||||||||:|||||||:|::|.||:.||:||.
Mouse   555 KLFLLNCVGQEMSRCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLMISIYSRRTMKRKEMIGWV 619

  Fly   551 SLGLNSSGSEEVAHWADVCEMPKGEMLARWHVLVDS 586
            :||.||||.||..||.::.| .||:...|||.|::|
Mouse   620 ALGQNSSGEEEQEHWEEMKE-SKGQQTCRWHTLLES 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	39/121 (32%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	89/137 (65%)
Syt16	NP_001351210.1	C2A_Synaptotagmin-14_16	359..482	CDD:176035	40/124 (32%)
Syt16	NP_001351210.1	C2B_Synaptotagmin-14_16	515..652	CDD:176053	89/137 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I4043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2607
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D339484at33208
OrthoFinder	1	1.000	-	-		FOG0002721
OrthoInspector	1	1.000	-	-		otm42447
orthoMCL	1	0.900	-	-		OOG6_109712
Panther	1	1.100	-	-	LDO	PTHR46129
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5537
SonicParanoid	1	1.000	-	-		X2510
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.000