DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt14 and Sytl5

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_808372.1	Gene:	Sytl5 / 236643	MGIID:	2668451	Length:	753	Species:	Mus musculus

Alignment Length:	648	Identity:	131/648 - (20%)
Similarity:	223/648 - (34%)	Gaps:	196/648 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 AVKCVQKITRKRRYENTSSDSEEDILRRLRWHQQHQLGEKPG----------------------- 103
            |.:||.|               .|.|..:|....|...:|.|
Mouse   159 AQQCVDK---------------SDTLSSVRQKTTHDGPKKKGFLLSKFRSATRGEIRTPKPESGR 208

  Fly   104 GYGLGISQANPLTAQSFNYHQAGA--SADL---------QRVTVSRDPLAIAERGKVGIPSSHSE 157
            .|.|.:...|..:.:|.:....|:  |:||         .:.:.|...:.:.:|..|  ||:||.
Mouse   209 SYSLDLDSQNLQSFKSASGSDRGSTTSSDLIDQEAGRRTSKSSYSNGGIPVTQRSPV--PSAHSV 271

  Fly   158 CSSNDSMEVSVDSHTGVLTGLSKATTTVPHPATAFRNPCGEHRAKTQALRYQHRVNVAAPP---- 218
            .|.| |.|...::        |.|..|:       .|.|.|       |...||.|.:..|
Mouse   272 TSIN-SREHGFEN--------SMALATI-------ENTCEE-------LTKSHRRNTSGTPSIAV 313

  Fly   219 ---KLDKERDNVLVVPMVNAYSINNNNNSITTSNNHPSSNNNDDEPLFDTSD------------- 267
               .|..||.. ..|.:..:::.:..:.|...|.:.|.:.:.|...|.||.|
Mouse   314 SGTSLSSERSR-SEVDLSESFAEDLEDTSSIRSRSVPGALDKDLNSLEDTEDGVDLVSSRFSANT 377

  Fly   268 --LRSIKSDDLLVGVDQKEPAVQ-----------------------------RGPIELELSLLYD 301
              |.|..|.:...|.|:|...:.                             .|.|.|.:|..|.
Mouse   378 HSLASGLSTNSQAGSDRKRSYLNVPDADSDTTSLNSMMSVYSETGDYGNVKVTGEILLHISYCYK 442

  Fly   302 APMRKMTVHVMQAKNLPPLGSG----QTTHTQVRMLMLP--SKKQKLKTKIRSGENPQYMESFLL 360
            .  ..:.:.|...:|   |.:|    |.|...|:..:||  |:..|.|||||:|.||::.|: |.
Mouse   443 T--GGLYIFVKSCRN---LATGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGTNPEFNET-LK 501

  Fly   361 HRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLWLPLEPRNTSSGLGSTSD 425
            :.::...:....|::.::..:|..:...:||..::|.:.:.|...:.|..|:|:
Mouse   502 YTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIAFDSWNFENPCDEWFVLQPK----------- 555

  Fly   426 LLSLARSESAGSTSSMQHGGVSELLLGLSY----------------------------NGVTGR- 461
             :.||      ...|:|:.|  ||.:.|.|                            :.::|.
Mouse   556 -VELA------PDISLQYKG--ELTIVLRYIPPEENLIFPAGQRQEKKIFKRGKKKESSSISGGI 611

  Fly   462 LSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETFAFQVALF-- 524
            |.|.|.|.....::......|::||..::.. ..:.::.||::.:...||.:..||.|. .|:
Mouse   612 LEVFIKKAKNLTAVKSGGTSDSFVKGYLLPD-DNKATKHKTAVVKKSVNPEWNHTFIFS-GLYPQ 674

  Fly   525 QLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGS-EEVAHWADVCEMPKGEMLARWHVLVDS 586
            .:.:..|.::::.|.....|..:|...|...|..| .:...|.|    ..||....|..:.|:
Mouse   675 DIKNACLELTIWDKEAFSSNVFLGGVRLNSGSGMSYGKTVDWMD----SHGEEQRLWQKMADN 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	33/127 (26%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	32/169 (19%)
Sytl5	NP_808372.1	PHD_SF	11..123	CDD:419867
		FYVE_Slp5	62..108	CDD:277305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..279		28/137 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..359		13/62 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..404		6/23 (26%)
		C2A_SLP-4_5	430..553	CDD:175995	33/128 (26%)
		C2B_SLP_1-2-3-4	567..745	CDD:175987	34/175 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810