DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt14 and Syt12

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_620190.1	Gene:	Syt12 / 191595	RGDID:	621876	Length:	421	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	110/526 - (20%)
Similarity:	181/526 - (34%)	Gaps:	167/526 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 EKPGGYGLGISQANPL--------------TAQSF----------------NYHQAGASADLQRV 134
            :.|.|:.:|:..|..|              |:.||                .|.:|...|.|:||
  Rat    14 KSPPGWEVGVYAAGALALLGIAAVSLWKLWTSGSFPSPSPFPNYDYRYLQQKYGEAYVEAKLKRV 78

  Fly   135 -------TVSRDPLAIAERGKVGIPSSHSECSSNDSMEVSVDSHTGVLTGLSKATTTVPHPATAF 192
                   |.:|.|           ||.....|..|:.| |: |..|.|..:.:.....|:
  Rat    79 PPWNAQRTTTRGP-----------PSRKGSLSIEDTFE-SI-SELGPLELMGRELDLAPY----- 125

  Fly   193 RNPCGEHRAKTQALRYQHRVNVAAPPKLDKERDNVLVVPMVNAYSINNNNNSITTSNNHPSSNNN 257
                |..|....|                                  ::.|||::.:|
  Rat   126 ----GTLRKSQSA----------------------------------DSLNSISSVSN------- 145

  Fly   258 DDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQRGPIELELSLLYDAPMRKMTVHVMQAKNLPPLGS 322
                         ....|..:|             ::|:|:.||.....:.|.|:|.|:|.....
  Rat   146 -------------TFGQDFTLG-------------QVEVSMDYDGASHTLHVAVLQGKDLLEREE 184

  Fly   323 GQTTHTQVRMLMLPSKKQKLKTKIRSGENPQYMESFLLHRVNPEDVNNMGLRVRLYGCERLRKER 387
            .......:|:.:||.::....::|:......:.:......::|..:....||..::|.:.
  Rat   185 ATFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSVPLDPTALEEKSLRFSVFGIDE----- 244

  Fly   388 LIGEAYVSFATVDLELETNLWLPLEPRNTSSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLLG 452
              .|..||...|:|:|.. |.|||:|         .|..|.|.....|..       .|.|:||.
  Rat   245 --DERNVSTGVVELKLSV-LDLPLQP---------FSGWLYLQDQNKAAD-------AVGEILLS 290

  Fly   453 LSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETF 517
            |||.....||:|.::|.......:.....|.:||:.::.. |:::|:.||:::|..|||:|.|..
  Rat   291 LSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQD-GRKMSKKKTAVKRDDPNPVFNEAM 354

  Fly   518 AFQVALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGEMLA---- 578
            .|.|....|.|::|.::|.......:.:.||...:|..:||. ...||        .:|||
  Rat   355 IFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPGASGM-GTTHW--------NQMLATLRR 410

  Fly   579 ---RWH 581
               .||
  Rat   411 PVSMWH 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	27/121 (22%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	42/143 (29%)
Syt12	NP_620190.1	C2	152..263	CDD:417471	25/131 (19%)
Syt12	NP_620190.1	C2B_Synaptotagmin-12	284..419	CDD:176051	42/143 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810