Protein Alignment Syt14 and Syt12

DIOPT Version :10

• Sequence 1: NP_001262249.1
• Gene: Syt14 / 40544
• FlyBaseID: FBgn0261086
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_620190.1
• Gene: Syt12 / 191595
• RGDID: 621876
• Length: 421
• Species: Rattus norvegicus
• Alignment Length: 526
• Identity: 110/526 - (20%)
• Similarity: 181/526 - (34%)
• Gaps: 167/526 - (31%)

  Fly   100 EKPGGYGLGISQANPL--------------TAQSF----------------NYHQAGASADLQRV 134
            :.|.|:.:|:..|..|              |:.||                .|.:|...|.|:||
  Rat    14 KSPPGWEVGVYAAGALALLGIAAVSLWKLWTSGSFPSPSPFPNYDYRYLQQKYGEAYVEAKLKRV 78

  Fly   135 -------TVSRDPLAIAERGKVGIPSSHSECSSNDSMEVSVDSHTGVLTGLSKATTTVPHPATAF 192
                   |.:|.|           ||.....|..|:.| |: |..|.|..:.:.....|:
  Rat    79 PPWNAQRTTTRGP-----------PSRKGSLSIEDTFE-SI-SELGPLELMGRELDLAPY----- 125

  Fly   193 RNPCGEHRAKTQALRYQHRVNVAAPPKLDKERDNVLVVPMVNAYSINNNNNSITTSNNHPSSNNN 257
                |..|....|                                  ::.|||::.:|
  Rat   126 ----GTLRKSQSA----------------------------------DSLNSISSVSN------- 145

  Fly   258 DDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQRGPIELELSLLYDAPMRKMTVHVMQAKNLPPLGS 322
                         ....|..:|             ::|:|:.||.....:.|.|:|.|:|.....
  Rat   146 -------------TFGQDFTLG-------------QVEVSMDYDGASHTLHVAVLQGKDLLEREE 184

  Fly   323 GQTTHTQVRMLMLPSKKQKLKTKIRSGENPQYMESFLLHRVNPEDVNNMGLRVRLYGCERLRKER 387
            .......:|:.:||.::....::|:......:.:......::|..:....||..::|.:.
  Rat   185 ATFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSVPLDPTALEEKSLRFSVFGIDE----- 244

  Fly   388 LIGEAYVSFATVDLELETNLWLPLEPRNTSSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLLG 452
              .|..||...|:|:|.. |.|||:|         .|..|.|.....|..       .|.|:||.
  Rat   245 --DERNVSTGVVELKLSV-LDLPLQP---------FSGWLYLQDQNKAAD-------AVGEILLS 290

  Fly   453 LSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKETF 517
            |||.....||:|.::|.......:.....|.:||:.::.. |:::|:.||:::|..|||:|.|..
  Rat   291 LSYLPTAERLTVVVVKAKNLIWTNDKTTADPFVKVYLLQD-GRKMSKKKTAVKRDDPNPVFNEAM 354

  Fly   518 AFQVALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGEMLA---- 578
            .|.|....|.|::|.::|.......:.:.||...:|..:||. ...||        .:|||
  Rat   355 IFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPGASGM-GTTHW--------NQMLATLRR 410

  Fly   579 ---RWH 581
               .||
  Rat   411 PVSMWH 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	27/121 (22%)
		C2B_Synaptotagmin-14_16	446..584	CDD:176053	42/143 (29%)
Syt12	NP_620190.1	C2	152..263	CDD:472691	25/131 (19%)
		C2B_Synaptotagmin-12	284..419	CDD:176051	42/143 (29%)