DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt14 and sytl3

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_021324208.1	Gene:	sytl3 / 101882017	ZFINID:	ZDB-GENE-040724-150	Length:	581	Species:	Danio rerio

Alignment Length:	387	Identity:	83/387 - (21%)
Similarity:	163/387 - (42%)	Gaps:	66/387 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 SNDSMEVSVDSHTGVLTGLSKATTTVPHPATAFRNPCGEHRAKTQALRYQHRVNVAAPPKLDKER 224
            |.:::..||.:|   :..|||:...:...|       |:.......:.|..|.:: :...:::..
Zfish   193 SMENLVASVSAH---IKKLSKSQNDLSEVA-------GQLTVDHGHMMYSRRKSL-SDGAINRAL 246

  Fly   225 DNVLVVPMVN-AYSINNNNNSITTSNNHPSSNNNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQ 288
            ..|..:|::: |.|.:.:...:|..:...:|..:||:           :..:...|:|.   .:.
Zfish   247 CKVPSLPILSTAQSTSTSTLCLTDDDVSSTSAYSDDQ-----------RDSNSSTGMDS---VLF 297

  Fly   289 RGPI----ELELSLLYDAPMRKMTVHVMQAKNLPPLGSGQTTHTQVRMLMLPSK--KQKLKTKIR 347
            ...|    |:|:.|.|:.....:.:.:...:||....:.:..|..|.:.:||.|  ..|:||.:|
Zfish   298 ENTISVTGEIEVVLAYNNRTSCLEITIKACRNLMFRDTKKKCHPYVNVCLLPKKCHNFKMKTAVR 362

  Fly   348 SGENPQYMESFLLHRVNPEDVNNMGLRVRLYGCERLRKERLIGEAYVSFATVDLE---LETNLWL 409
            .|:||.|.|:|.. .::.:.:::..|::.::....|::...:||..:..|.:|||   .:.:|..
Zfish   363 KGKNPVYNETFTC-VLSADLLSSAVLQLSVWHSRGLKRRLFLGETLIRLADMDLEDTDSQRSLCC 426

  Fly   410 PLEPRNTSSG----LGSTSDLLSL-ARSESAGSTSSMQHGGVSELLLG------LSYNGVTGRLS 463
            .|.|:....|    |..||.||.: |:..:....::..||    :|||      :.:..|:..||
Zfish   427 KLNPKAPQLGGDAELQFTSVLLLIQAQFHTLPHNNTQTHG----VLLGAPGQLTVLFTDVSKLLS 487

  Fly   464 VEIIKGSQF-------------RSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPL 512
            |.  |.:.|             |..|..|..|..::|...|...||:.:|..::...:.|.|
Zfish   488 VS--KTAHFEGILCLPGHRELVRKTSALKKTDGSIRMSFSSLSQQELQQATLTLNLWEKNCL 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	32/130 (25%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	20/86 (23%)
sytl3	XP_021324208.1	PHD_SF	27..134	CDD:328929
		FYVE_like_SF	73..120	CDD:333710
		C2	304..429	CDD:326325	30/125 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810