DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt14 and sytl4

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_031746962.1	Gene:	sytl4 / 100495134	XenbaseID:	XB-GENE-958567	Length:	692	Species:	Xenopus tropicalis

Alignment Length:	522	Identity:	113/522 - (21%)
Similarity:	206/522 - (39%)	Gaps:	127/522 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 SQANPL----TAQSFNYHQAGASADLQRVTV---SRDPLAIAERGKVGIPSSHSECSSNDSMEVS 167
            |:.|.|    |.|.....|....|::..:||   |||.......|: .:..|.|..|:::|..:.
Frog   222 SRRNSLEKSATLQDAKRAQGPVGANVATLTVPVRSRDRHQSDSEGE-ALLGSRSAGSADESDTLF 285

  Fly   168 VDSHTGVL--TGLSKATTTV-PHPATAFRNPCGEHRAKTQALRYQHRVNVAAPPKLDKERDNVLV 229
            ..:...:|  ...||:...: |.||....|..|: |:|:..     |:|:....: |::.||::.
Frog   286 KKNPRRLLKPADYSKSVLDLRPEPAAPEENALGD-RSKSVP-----RLNIEMEEE-DEDIDNLVE 343

  Fly   230 VPMVNA--YSINNNNNSITTSNNHPSSNNNDDEPLFDTSDLRSIKSDD------LLVGVDQKEPA 286
            :..::|  .|:.:..:|.|..:                  :.||.|:.      ::.|
Frog   344 IHRLSAGRSSLRSGASSSTLGS------------------MISIYSEAGDFGNVIITG------- 383

  Fly   287 VQRGPIELELSLLYDAPMRKMTVHVMQAKNLPPLGS--GQTTHTQVRMLMLPSKKQ--KLKTKI- 346
                  |:..|:.|||.::.:.:.|.:.:|| ..|.  ...::..::..:||.|.:  |.||.|
Frog   384 ------EIIFSINYDAKVQLLNILVKECRNL-AYGDELKMRSNPYIKSYLLPDKSRQGKRKTTIK 441

  Fly   347 RSGENPQYMESFLLHRVNPEDVNNM-GLRVRLYGCERLRKERLIGEAYVSFATVDLELETNLW-- 408
            |:..||.|.|  :|..:.||.:.:: .|.:.::..:|..:...:|:       ||:.|::  |
Frog   442 RNTTNPMYNE--VLKYIVPESMLHLRSLELSVWHYDRFGRNTFLGQ-------VDIPLDS--WNF 495

  Fly   409 -------LPLEPR-NTSSGLGSTSDLLSLARSESAGSTSSMQHGGVSELLLGLSYNGVT------ 459
                   |||..: |..||.|.                    :....||::.|.|...|
Frog   496 DSLIEECLPLHGKGNMDSGAGF--------------------YNSKGELVVSLKYVPPTKPSGSE 540

  Fly   460 ---------GRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPLFKE 515
                     |.|.|.|.:.....::......|::||..:.....:...| ||.:.:...||.:..
Frog   541 RRKKKADEGGELHVWIKEAKNLTAVKTGGISDSFVKGYLFPHKNKNTKR-KTPVVKKTLNPHYNH 604

  Fly   516 TFAFQ-VALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGL-NSSGSEEVAHWADVCEMPKGEMLA 578
            ||.:. :....|.:|.|.::|:.:..:..|:.:|...||: |...:.|:..|.|    ..||.|:
Frog   605 TFVYNGIKPEDLQNVCLELTVWDREPLSSNDFLGGVRLGIGNGMSNGELVDWMD----STGEELS 665

  Fly   579 RW 580
            .|
Frog   666 LW 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	34/136 (25%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	35/152 (23%)
sytl4	XP_031746962.1	PHD_SF	15..126	CDD:419867
		FYVE_Slp4	63..112	CDD:277303
		C2A_SLP-4_5	382..506	CDD:175995	34/148 (23%)
		C2B_SLP_1-2-3-4	521..685	CDD:175987	35/152 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910